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What Is Aptivus Used For

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Brand name: Aptivus Generic name: tipranavir, or TPV Class: Protease inhibitor (PI) Manufacturer: Boehringer Ingelheim, , (800) 542-6257 AWP: $1,420.09/month; $419.84 for 95 mL bottle of solution Standard Dose: Two 250 mg capsules with two 100 mg capsules of Norvir, both twice daily. Must be taken with Norvir. Oral solution available; both formulations available for children ages 2 years and older. Must take with...
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Doc,I've read a lot about Aptivus being good for people who have had resistance to other drugs. Is it ever used for people just starting treatment? As someone who has recently tested positive I'm weighing all my options.Thanks! Rob...
Gerald Pierone, M.D.

Response from Gerald Pierone, M.D.

AIDS Research and Treatment Center of the Treasure Coast
Aptivus is also known as tipranavir and is a recently approved protease inhibitor that has activity against virus that is multi-drug resistant. It is typically used as part of a salvage regimen for patients that have drug-resistant virus. There are... Read more »

What to do - Aptivus?

Doctor, vircotype phenotpype showed mutations at 41L, 43Q, 118I, 210W, 211K and 215S and said I had susecptibility to all NRTI's, "maximal" to retrovir. No nNRTI mutations. PI mutations at 10I, 13V,, 33F, 46I, 48V, 54T, 71V, 74S,...
Gerald Pierone, M.D.

Response from Gerald Pierone, M.D.

AIDS Research and Treatment Center of the Treasure Coast
Hello and thanks for posting. The best answer to your question will depend on some additional information: viral load, CD4 count, previous treatment history, prior resistance tests, and any known antiretroviral medications intolerances. The short... Read more »

RE What to do - Aptivus

Doctor, thank you for your speedy response. To answer your question, I am six years poz. Treatment naive. Last VL's over the past year ranging 250 to now 158. About 8% each time CD4 to CD8. I know I have these NNRTI mutations...
Gerald Pierone, M.D.

Response from Gerald Pierone, M.D.

AIDS Research and Treatment Center of the Treasure Coast
It is quite unusual, but not unheard of, to have so many resistance mutations in someone who is nave to treatment. But based on the resistance test from your previous <a... Read more »

should I be worried about aptivus?

Hi,I just read on this site about a "black box" warning that Aptivus can cause "intracranial hemmorrage". What does this mean, and is this something I should be worried about?Thanks -- JD...
Benjamin Young, M.D., Ph.D.

Response from Benjamin Young, M.D., Ph.D.

Rocky Mountain CARES
The "black box" means that the FDA has issued a significant need-to-know about drug safety.In the case of tipranavir (Aptivus), a small, but significant number of patients developed intracranial hemmorrhage (ICH, bleeding in the brain)... Read more »
Connect With Others

maintaining hope

Posted by breathe, 3 Replies
I have been taking meds for three years now and phenotype and genotype testing have shown i have extreme resistance i think i may have one regiment that may work and it would include just trying to remember we are not guaranteed any... Read more »

nuevo medicamento par el vih

Posted by Anonymous, 2 Replies
La FDA (la agencia que regula los medicamentos en Estados Unidos) han informado de que pacientes que tomaban el frmaco para el sida Aptivus (tripanavir) han sufrido una hemorragia cerebral y ocho de ellos han fallecido

En los ensayos clinicos con... Read more »

Re: Something uplifting

Posted by SA_Intellect, 3 Replies
The link below is the response one of the doctors on The Body posted to my question. Read it. It's very positive and will hopefully add a bit of peace to some your hearts. Read more »

Just started ARV - Insurance, Drug costs, expenses

Posted by ajhope, 1 Reply
I live in Thailand and found out I am HIV+ a little over a month ago. My CD4 count was 251 and VL 29,000 - I started ARV 2 weeks ago with the following regiments:
Nevirapine 200 mg - once a day
Lamivudine 150 mg - twice a day
Stavudine 30 mg - twice... Read more »