What Is Stavudine

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Stavudine (Zerit)

What Is Stavudine? Stavudine (Zerit) is a drug used as part of antiretroviral therapy (ART). It is manufactured by Bristol-Myers Squibb. The original patent on stavudine has expired. The U.S. Food and Drug Administration (FDA) approved generic forms of stavudine for sale in the U.S. and under PEPFAR (see Fact Sheet 475 ). Stavudine is also known as d4T or didehydro-deoxythymidine. Stavudine is the most commonly used anti-HIV medication...

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Can I take Zerit (Stavudine, d4T) with Viread (Tenofovir).

Hi, I just had a quick question. I've been researching everywhere but couldnt find an answer, if I'm taking Zerit (Stavudine, d4T) and Sustiva (Efavirenz, Stocrin), can I take Viread (Tenofovir).Thanks so much for all your help. God bless. ...

Response from Benjamin Young, M.D., Ph.D.

Rocky Mountain CARES

Hello and thank you for your post.While d4T (Zerit) is not routinely used with tenofovir (Viread, Truvada),nor is this a commonly used NRTI backbone to be taken with efavirenz, there's no particular reason why the two drugs couldn't be... Read more »

Forgot dose of stavudine (2 hours)

I forgot to take my stavudine dose on time and I ended up taking it 2 hours later. What is the probability of this causing resistance? Is there a window of time to take the missed dose that is relatively safe? Thank you....

Response from Keith Henry, M.D.

University of Minnesota, School of Medicine

Should not be a problem. KH... Read more »

resistance to stavudine

Is there any data that explains why some patients experience clinical failure on a regimen containing stavudine if there are no clinically observed codon mutations linked to stavudine resistance?...

Response from Mark Holodniy, M.D., F.A.C.P., C.I.C.

Stanford University, School of Medicine

Good question and hard to get an answer. A couple of points though. Although we can't seem to find the mutation we believe causes d4T resistance in the test tube in people, we see the cases you describe. This may be related to other mutations... Read more »

Stavudine toxicity

what can used in conjuction with lamivudine, stocrin in place of stavudine?What do we need to do to prevent pre-mature aging of body cells?...

Response from Keith Henry, M.D.

University of Minnesota, School of Medicine

If available and depending on the nature of the problems with stavudine, it is most often switched to tenofovir or abacavir (if HLA B5701 negative or low risk for hypersensitivity reactio) or ziduvudine. Avoiding premature aging in the setting of... Read more »

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Posted by Anonymous, 2 Replies

My friend has taken Stavudine, Lamivudine and Nevirapine for a month. At the end of the month her Doctor found in a Blood test increased SGPT (550 U/L), SGOT (310 U/L) and Alkaline Phosphatase (1080 U/L).
In two days after a repeated test the... Read more »

pregnancy and HIV

Posted by footeard, 1 Reply

Hi, I have been positive since 1987 and my husband is negative. I am 30 years old. We will be trying to concieve and have a baby in July. I am currently on D4T, Viramune and DDI. I was on AZT monotherapy from 92-94 at 300 mg a day so likely am... Read more »

Does changing cocktails help?

Posted by Anonymous, 1 Reply

I've been on the same cocktail for over 3 years
now:Crixivan, Delaverdine (sp?), & Viracept (Tried,
d4t, 3tc, ddi & ddc..major neuropathy problems. Azt
made me vrey sick!). I've had below 50 copies viral
load for 3 years (the old... Read more »

My chin and body are horrid, HELP!

Posted by Jaz, 2 Replies

Anyone have advice to make me feel better. Have been taking d4t and my chin is so large and my face round, my stomach and abdomen getting larger. Feel so depressed. Doc says can't get rid of it. Can't change meds as this the only one I can... Read more »

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