What Is Stavudine Used For

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Stavudine (Zerit)

What Is Stavudine? Stavudine (Zerit) is a drug used as part of antiretroviral therapy (ART). It is manufactured by Bristol-Myers Squibb. The original patent on stavudine has expired. The U.S. Food and Drug Administration (FDA) approved generic forms of stavudine for sale in the U.S. and under PEPFAR (see Fact Sheet 475 ). Stavudine is also known as d4T or didehydro-deoxythymidine. Stavudine is the most commonly used anti-HIV medication...

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Can I take Zerit (Stavudine, d4T) with Viread (Tenofovir).

Hi, I just had a quick question. I've been researching everywhere but couldnt find an answer, if I'm taking Zerit (Stavudine, d4T) and Sustiva (Efavirenz, Stocrin), can I take Viread (Tenofovir).Thanks so much for all your help. God...

Response from Benjamin Young, M.D., Ph.D.

Rocky Mountain CARES

Hello and thank you for your post.While d4T (Zerit) is not routinely used with tenofovir (Viread, Truvada),nor is this a commonly used NRTI backbone to be taken with efavirenz, there's no particular reason why the two drugs couldn't be combined as... Read more »

Forgot dose of stavudine (2 hours)

I forgot to take my stavudine dose on time and I ended up taking it 2 hours later. What is the probability of this causing resistance? Is there a window of time to take the missed dose that is relatively safe? Thank you. Forgot dose of stavudine (2...

Response from Keith Henry, M.D.

University of Minnesota, School of Medicine

Should not be a problem. KH... Read more »

resistance to stavudine

Is there any data that explains why some patients experience clinical failure on a regimen containing stavudine if there are no clinically observed codon mutations linked to stavudine resistance? resistance to stavudine Good question and hard to...

Response from Mark Holodniy, M.D., F.A.C.P., C.I.C.

Stanford University, School of Medicine

Good question and hard to get an answer. A couple of points though. Although we can't seem to find the mutation we believe causes d4T resistance in the test tube in people, we see the cases you describe. This may be related to other mutations that... Read more »

Stavudine toxicity

what can used in conjuction with lamivudine, stocrin in place of stavudine?What do we need to do to prevent pre-mature aging of body cells? Stavudine toxicity If available and depending on the nature of the problems with stavudine, it is most often...

Response from Keith Henry, M.D.

University of Minnesota, School of Medicine

If available and depending on the nature of the problems with stavudine, it is most often switched to tenofovir or abacavir (if HLA B5701 negative or low risk for hypersensitivity reactio) or ziduvudine. Avoiding premature aging in the setting of... Read more »

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Articles

FDA Approval of Three Generic Stavudine Formulations

On December 29, 2008 FDA granted approval for three generic fomulations of stavudine. Stavudine is a Nucleoside Reverse Transcriptase Inhibitors (NRTI), which helps keep HIV, the virus that causes AIDS, from reproducing. It is intended to be used in... Read more »

La Guía Annual de Medicamentos para el VIH: Zerit (Stavudine, d4T)

Nombre de Marca: Zerit Nombre Común: stavudine o d4T Clase: nucleósido análogo (también llamado inhibidor de la transcriptasa reversa del nucleósido, NRTI, siglas en inglés) Dosis estándar: Una cápsula de... Read more »

An Overview of Zerit (Stavudine, d4T)

STAV-yoo-deen Brand Name: Zerit Other Name(s): BMY-27857, Estavudina, d4T Drug Class: Nucleoside Reverse Transcriptase Inhibitors Stavudine, also known as Zerit or d4T, is a type of medicine called a nucleoside reverse... Read more »

U.S. Centers for Disease Control and Prevention

Stavudine, Other Antiretrovirals Tied to New Onset Diabetes in HIV

A new report has found that exposure to stavudine -- and, to a lesser degree, zidovudine and didanosine -- is linked to an increased risk of new onset diabetes in HIV-positive patients. Researchers examined data on 33,389 HIV patients enrolled in... Read more »

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Need Help

Posted by Anonymous, 2 Replies

My friend has taken Stavudine, Lamivudine and Nevirapine for a month. At the end of the month her Doctor found in a Blood test increased SGPT (550 U/L), SGOT (310 U/L) and Alkaline Phosphatase (1080 U/L).
In two days after a repeated test the... Read more »

pregnancy and HIV

Posted by footeard, 1 Reply

Hi, I have been positive since 1987 and my husband is negative. I am 30 years old. We will be trying to concieve and have a baby in July. I am currently on D4T, Viramune and DDI. I was on AZT monotherapy from 92-94 at 300 mg a day so likely am... Read more »

Does changing cocktails help?

Posted by Anonymous, 1 Reply

I've been on the same cocktail for over 3 years
now:Crixivan, Delaverdine (sp?), & Viracept (Tried,
d4t, 3tc, ddi & ddc..major neuropathy problems. Azt
made me vrey sick!). I've had below 50 copies viral
load for 3 years (the old... Read more »

My chin and body are horrid, HELP!

Posted by Jaz, 2 Replies

Anyone have advice to make me feel better. Have been taking d4t and my chin is so large and my face round, my stomach and abdomen getting larger. Feel so depressed. Doc says can't get rid of it. Can't change meds as this the only one I can... Read more »

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