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What Is Aptivus

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Test Positive Aware Network


Common Name: tipranavir (TPV) Brand Name: Aptivus Class: HIV protease inhibitor (PI) Standard dose: Two 250 mg capsules with two 100 mg capsules of Norvir, both twice daily. Must be taken with Norvir. Oral solution available; both formulas available for children and adults. Can be taken with or without food, with no food restrictions, but preferably with food to improve Norvir tolerability. Take missed dose as soon as...
Ask the Experts

aptivus side effects

Hi Iam curently on the combo.of500mg./aptivus2daily, didanasone400mg.1day, norvir200mg2day and 150mg.epivir1day. I have been pos.for23yrs.and am multi drug resistant.Thank the lord that this combination has been working for me for 2and a half years...
Keith Henry, M.D.

Response from Keith Henry, M.D.

University of Minnesota, School of Medicine
Sounds like you are having a good response to your regimen.Tiprinavir + ritonavir can increase blood levels of cholesterol and triglycerides but generally the levels haven't placed patients ( a small subset of patients have very serious increase in... Read more »

should I be worried about aptivus?

Hi,I just read on this site about a "black box" warning that Aptivus can cause "intracranial hemmorrage". What does this mean, and is this something I should be worried about?Thanks -- JD
Benjamin Young, M.D., Ph.D.

Response from Benjamin Young, M.D., Ph.D.

Rocky Mountain CARES
The "black box" means that the FDA has issued a significant need-to-know about drug safety.In the case of tipranavir (Aptivus), a small, but significant number of patients developed intracranial hemmorrhage (ICH, bleeding in the brain) while... Read more »

aptivus & prezista

what are the mutations these drugs are resistant to?
Mark Holodniy, M.D., F.A.C.P., C.I.C.

Response from Mark Holodniy, M.D., F.A.C.P., C.I.C.

Stanford University, School of Medicine
They are long lists. The mutations associated with tipranvir (Aptivus) include: L33F, V82T, I84V, L90M. Others that can affect susceptibility include: L10V, I13V, K20R, E35G, M36I, K43T, M46L, I47V, I54A, Q58E, H69K, T74P, N83D. Mutations associated... Read more »


Doc,I've read a lot about Aptivus being good for people who have had resistance to other drugs. Is it ever used for people just starting treatment? As someone who has recently tested positive I'm weighing all my options.Thanks! Rob
Gerald Pierone, M.D.

Response from Gerald Pierone, M.D.

AIDS Research and Treatment Center of the Treasure Coast
Aptivus is also known as tipranavir and is a recently approved protease inhibitor that has activity against virus that is multi-drug resistant. It is typically used as part of a salvage regimen for patients that have drug-resistant virus. There are... Read more »

An Overview of Aptivus (Tipranavir)

tip-RAN-na-veer --> Brand Name: Aptivus Other Name(s): TPV Drug Class: Protease Inhibitors Tipranavir, also known as TPV or Aptivus, is a type of medicine called a protease inhibitor (PI). PIs work by blocking protease, a... Read more »
AIDS InfoNet

Tipranavir (Aptivus)

What Is Tipranavir? Who Should Take It? What About Drug Resistance? How Is It Taken? What Are the Side Effects? How Does It React With Other Drugs? What Is Tipranavir? Tipranavir is a drug used as part of antiretroviral therapy... Read more »
The Body's "Ask the Experts" Forums

FAQs About Tipranavir (Aptivus) From The Body's "Ask the Experts" Forums

Side Effects | General Treatment | Switching Treatment Side Effects High Lipid Levels From Aptivus? I have been taking Aptivus (tipranavir) as part of my drug regimen for two and a half years. My viral load is undetectable, and my... Read more »
Boehringer Ingelheim

U.S. FDA Approves New Anti-HIV Drug Aptivus for Use in Combination Therapy

Aptivus(r) (tipranavir) was approved yesterday by the FDA for the treatment of HIV-positive adults with evidence of viral replication, who are highly treatment-experienced or have HIV-1 strains resistant to multiple protease inhibitors. ... Read more »
Connect With Others

Just started ARV - Insurance, Drug costs, expenses

Posted by ajhope, 1 Reply
I live in Thailand and found out I am HIV+ a little over a month ago. My CD4 count was 251 and VL 29,000 - I started ARV 2 weeks ago with the following regiments: Nevirapine 200 mg - once a day Lamivudine 150 mg - twice a day Stavudine 30 mg -... Read more »

Thanks for your support and any more advice?

Posted by motherinlaw, 3 Replies
I want to thank everyone for their support and help. I posted this in response to my own previous posting and felt it might have gotten lost in the shuffle and so am reposting. I have just spoken to my son again. He was finally able to convince... Read more »

nuevo medicamento par el vih

Posted by Anonymous, 2 Replies
La FDA (la agencia que regula los medicamentos en Estados Unidos) han informado de que pacientes que tomaban el frmaco para el sida Aptivus (tripanavir) han sufrido una hemorragia cerebral y ocho de ellos han fallecido En los ensayos clinicos con... Read more »

Re: Something uplifting

Posted by SA_Intellect, 3 Replies
The link below is the response one of the doctors on The Body posted to my question. Read it. It's very positive and will hopefully add a bit of peace to some your hearts. Read more »