What Is Aptivus

Here's a taste of what TheBody.com has to offer on this topic:

Get the Facts

Aptivus

Common Name: tipranavir (TPV) Brand Name: Aptivus Class: HIV protease inhibitor (PI) Standard dose: Two 250 mg capsules with two 100 mg capsules of Norvir, both twice daily. Must be taken with Norvir. Oral solution available; both formulas available for children and adults. Can be taken with or without food, with no food restrictions, but preferably with food to improve Norvir tolerability. Take missed dose as soon as possible,...

Ask the Experts

Aptivus

Doc,I've read a lot about Aptivus being good for people who have had resistance to other drugs. Is it ever used for people just starting treatment? As someone who has recently tested positive I'm weighing all my options.Thanks! Rob...

Response from Gerald Pierone, M.D.

AIDS Research and Treatment Center of the Treasure Coast

Aptivus is also known as tipranavir and is a recently approved protease inhibitor that has activity against virus that is multi-drug resistant. It is typically used as part of a salvage regimen for patients that have drug-resistant virus. There are... Read more »

What to do - Aptivus?

Doctor, vircotype phenotpype showed mutations at 41L, 43Q, 118I, 210W, 211K and 215S and said I had susecptibility to all NRTI's, "maximal" to retrovir. No nNRTI mutations. PI mutations at 10I, 13V,, 33F, 46I, 48V, 54T, 71V, 74S,...

Response from Gerald Pierone, M.D.

AIDS Research and Treatment Center of the Treasure Coast

Hello and thanks for posting. The best answer to your question will depend on some additional information: viral load, CD4 count, previous treatment history, prior resistance tests, and any known antiretroviral medications intolerances. The short... Read more »

RE What to do - Aptivus

Doctor, thank you for your speedy response. To answer your question, I am six years poz. Treatment naive. Last VL's over the past year ranging 250 to now 158. About 8% each time CD4 to CD8. I know I have these NNRTI mutations...

Response from Gerald Pierone, M.D.

AIDS Research and Treatment Center of the Treasure Coast

It is quite unusual, but not unheard of, to have so many resistance mutations in someone who is nave to treatment. But based on the resistance test from your previous post it is very likely that you would respond to a combination of Viread, 3TC,... Read more »

should I be worried about aptivus?

Hi,I just read on this site about a "black box" warning that Aptivus can cause "intracranial hemmorrage". What does this mean, and is this something I should be worried about?Thanks -- JD should I be worried about aptivus? The...

Response from Benjamin Young, M.D., Ph.D.

Rocky Mountain CARES

The "black box" means that the FDA has issued a significant need-to-know about drug safety.In the case of tipranavir (Aptivus), a small, but significant number of patients developed intracranial hemmorrhage (ICH, bleeding in the brain) while... Read more »

Go to Ask the Experts »

Articles

AIDS Community Research Initiative of America

Aptivus (Tipranavir)

(In the Fall of 2003, ACRIA Update's "Drugs! Drugs! Drugs!" issue gave an overview of all the FDA-approved HIV drugs. Since that issue, one new HIV drug has been approved. We present it here for those wishing to add it to that issue, which is... Read more »

FAQs About Tipranavir (Aptivus) From The Body's "Ask the Experts" Forums

Side Effects | General Treatment | Switching Treatment Side Effects High Lipid Levels From Aptivus? I have been taking Aptivus (tipranavir) as part of my drug regimen for two and a half years. My viral load is undetectable, and my CD4... Read more »

Boehringer Ingelheim Provides Update on Aptivus (Tipranavir) Clinical Trial in Treatment-Naive HIV-Infected Patients

Ingelheim/Germany -- Boehringer Ingelheim is actively conducting a clinical trial program to further evaluate Aptivus® (tipranavir) capsules for the treatment of HIV-1 infection. The program is comprised of ongoing and planned studies in more than... Read more »

FDA Updates Black Box Warning on Boehringer Ingelheim's Protease Inhibitor Aptivus to Treat Drug-Resistant HIV

FDA and Boehringer Ingelheim on Friday updated the black box warning on Boehringer's protease inhibitor Aptivus, which is used in combination with Abbott Laboratories ' Norvir for people living with HIV/AIDS who have become resistant to other... Read more »

Connect With Others

maintaining hope

Posted by breathe, 3 Replies

I have been taking meds for three years now and phenotype and genotype testing have shown i have extreme resistance i think i may have one regiment that may work and it would include fuzeon....im just trying to remember we are not guaranteed any... Read more »

nuevo medicamento par el vih

Posted by Anonymous, 2 Replies

La FDA (la agencia que regula los medicamentos en Estados Unidos) han informado de que pacientes que tomaban el frmaco para el sida Aptivus (tripanavir) han sufrido una hemorragia cerebral y ocho de ellos han fallecido

En los ensayos clinicos con... Read more »

Re: Something uplifting

Posted by SA_Intellect, 3 Replies

The link below is the response one of the doctors on The Body posted to my question. Read it. It's very positive and will hopefully add a bit of peace to some your hearts.

http://www.thebody.com/Forums/AIDS/TreatExp/Archive/Pipeline/Q173719.html ... Read more »

Just started ARV - Insurance, Drug costs, expenses

Posted by ajhope, 1 Reply

I live in Thailand and found out I am HIV+ a little over a month ago. My CD4 count was 251 and VL 29,000 - I started ARV 2 weeks ago with the following regiments:
Nevirapine 200 mg - once a day
Lamivudine 150 mg - twice a day
Stavudine 30 mg - twice... Read more »

Connect on Our Bulletin Boards »

Tools

My Health Tracker

Assess Your Risk for HIV

Find Local HIV/AIDS Services

Find a Therapist

Resource Centers

Guides for People With HIV

View All of Our Guides >>