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What Does Reverse Transcriptase Do During An HIV Infection?

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AIDS InfoNet

Non-Nucleoside Reverse Transcriptase Inhibitors in Development

Note: Several fact sheets describe drugs that are being tested against HIV: Fact Sheet 410 : nucleoside analog reverse transcriptase inhibitors (nukes) Fact Sheet 440 : protease inhibitors Fact Sheet 460 : attachment and fusion inhibitors Fact Sheet 470 : new classes of antiretroviral drugs Fact Sheet 480 : immune therapies These drugs have not been approved by the Food and Drug Administration (FDA) for use against HIV. ...
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Testing for Reverse Transcriptase

Dear Dr. Holodniy, I have a question regarding the enzyme reverse transcriptase. Is the enzyme present in all HIV infections, as well as other retroviruses. If so, how do you test for the enzyme in a patient?Thanks a lot....
Mark Holodniy, M.D., F.A.C.P., C.I.C.

Response from Mark Holodniy, M.D., F.A.C.P., C.I.C.

Stanford University, School of Medicine
THe enzyme is present in all HIV infections and other retroviral infections. We don't normally test for the RT or RT activity directly. A western blot test, will detect antibodies that have developed against the RT part of the virus. A new test... Read more »

Reverse Transcriptase Enzyme

Dear Dr. Conway, How are you doing? This isn't the right forum to post my question, but after reading many of your responses and your bio-I truly value your advice. What are some tests that a doctor could run besides the HIV tests that...
Brian Conway, M.D.

Response from Brian Conway, M.D.

University of British Columbia
I would start by saying that the conventional antibody test is very reliable. If the result is negative 6 or more months after a suspected exposure, you can take it for granted that you are NOT infected. In special circumstances, I would confirm... Read more »

TESTING for reverse transcriptase

Dear Dr. Conway, As this is a forum for managing side effects of HIV treatment, I was wondering if you can just very quickly answer a question. How do you test for the reverse transcriptase enzyme. Where can you go to be tested for it?Thanks a...
Brian Conway, M.D.

Response from Brian Conway, M.D.

University of British Columbia
This is an experimental test done for research purposes only, in which a DNA/RNA hetrodimer is exposed to the test sample in question (plasma or cell extract) to see if it acts to extend the DNA (a task that can only be accomplished by a reverse... Read more »

reverse transcriptase

What is reverse transcriptase and how does it work?...
Mark Holodniy, M.D., F.A.C.P., C.I.C.

Response from Mark Holodniy, M.D., F.A.C.P., C.I.C.

Stanford University, School of Medicine
Reverse transcriptase is an enzyme (or protein) that the HIV virus carries to make a DNA copy of itself once it gets inside a cell. This DNA copy can then get inside the cell nucleus and become incorporated into the human cell DNA. The enzyme takes... Read more »
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AbacavirLamivudine to treat HIV infection.

Posted by jenniferdraper
AbacavirLamivudine is used to treat HIV infection. This combination medication is used with other medications. It belongs to a class of drugs known as nucleoside reverse transcriptase inhibitors. Read more »

blood counts can indicate infection

Posted by Anonymous, 4 Replies
As an old timer of this board having had ALL the ars symptoms and 20 negative HIV tests including PCR’s DNA bDNA I recently received the results from a blood count that shows my lymphocyte percentage which was 45 right at the top of the... Read more »

reversing lipodystrophy....

Posted by Anonymous, 1 Reply
Positive since 2003 full blown aids. Was on Kaletra and combivir. Reached non-detectable, and cd4 rising as expected. Into 3rd year noticing increase in truncal girth. Waist went from 27in. to 32in of hard solid protruding fat. Arms, legs, face... Read more »

immunosilent infection

Posted by Anonymous, 1 Reply
hallo, here is tom. I have a question for experts. I have read about "immunosilent hiv".(infection without antibodys) Anybody know ,how often it is? And would a pcr detect an immunosilent infection? I have tested for 18 months(hiv1 and hiv2) neg.,... Read more »