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What Does Saquinavir Do

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AIDS InfoNet

Saquinavir (Invirase)

What Is Saquinavir? Saquinavir, also called Invirase, is a drug used as part of antiretroviral therapy (ART). There used to be a version called Fortovase that is no longer made. Saquinavir is manufactured by Roche Laboratories. Saquinavir is a protease inhibitor. These drugs prevent the protease enzyme from working. HIV protease acts like a chemical scissor. It cuts the raw material for HIV into specific pieces needed to build a new virus....
Ask the Experts


would you do me a favor?i need pictures of package of's very important to me and my life.could you describe small package of saquinavir?are there 3 line on the package of that?please tell me ....i must know what packages of...
Benjamin Young, M.D., Ph.D.

Response from Benjamin Young, M.D., Ph.D.

Rocky Mountain CARES
Pictures would be difficult to reproduce here--Inverase is a green and yellow capsule that says "Roche 0245" on the side.Fortovase is a larger tan colored capsule that says "Roche 0246".Hope this helps. BY... Read more »

switched to Ratonavir/Saquinavir question

Dr. Gallant: I just read you answer to the February 7th question on switching toRatonavir and Saquinavir. Now I am reallyconfused. I took your suggestion and went on 400mg of Ratonavir and 400mg. of Saquinavir bid. I am really fatiqued andfeel...
Joel Gallant, M.D.

Response from Joel Gallant, M.D.

Johns Hopkins University, School of Medicine
You don't waste any time! Please remember that I'm not here to give "suggestions"-- those should come from your doctor. But since you've already changed your therapy, I'll just make a few comments on the... Read more »


Should all patients on Saquinavir be switched to gelcaps? a medical provider...
Cal Cohen, M.D., M.S.

Response from Cal Cohen, M.D., M.S.

Harvard Medical School
When the soft-gel caps are released, it would seem reasonable to switch everyoneover from the old formulation to the new one, since you will be able to achieve higher drug levels with somewhat fewer pills.... Read more »

gastrointestinal problems with ratonavir &Saquinavir

Dr Gallant, Is there anything you know of, that can be taken or done for the gastrointestinal problems caused from ratonavirand saquinavir combo.? I am refering to the stomach cramps and extreme flatulance. I am taking 3 phaysyme tablets a dayand I...
Joel Gallant, M.D.

Response from Joel Gallant, M.D.

Johns Hopkins University, School of Medicine
My experience with ritonavir is that people either seem to get diarrhea or flatulence. (In other words, you either suffer yourself, or you let everyone else suffer for you.) For some of my patients with the latter problem, simethicone (which is... Read more »
Connect With Others

Med resistance on Norvir/Saquinivar..anyone else?

Posted by Anonymous, 1 Reply
I have been on Norvir/Saquinavir for 7 years. Starting to show resistance. Panicking a little, they worked for so long,
controlled side effects. Doctor wants to do labs more frequently for now but not switch, maybe add another drug.
Has anyone gone... Read more »


Posted by Anonymous
I am on Norvir/Saquinavir. HIV+ since 1990. I have noticed that sometimes I just plain feel like CRAP...a fatigue that resembles the flu. Sometimes lasts one day, sometimes a few. Don't know if HIV "related", or possibly side effects of the meds.... Read more »

Need Ritonavir

Posted by Anonymous
Dear Friends

I am a person living with HIV for 11 years now. Up until now I have not taken any medications apart from vitamin supplements. I have been in conflict with myself on whether to start HAART and after much sole searching have decided to... Read more »

What do you think?

Posted by Anonymous, 2 Replies
Researchers Find AIDS Drugs Cause T Cell Death in Healthy, HIV Negative

In the June 2, 2002 issue of Journal of Virology, researchers report an
astounding... Read more »