What Does Nevirapine Treat

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Nevirapine (Viramune)

What Is Nevirapine? Nevirapine is a drug used as part of antiretroviral therapy (ART). It is also called Viramune. It is manufactured by Boehringer Ingelheim. Generic versions have been tentatively approved under PEPFAR (see Fact Sheet 475 ). Nevirapine is a non-nucleoside reverse transcriptase inhibitor (a "non-nuke" or NNRTI). These drugs stop HIV from multiplying by preventing the reverse transcriptase enzyme from working. This enzyme changes...

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Nevirapine rash

How do you feel about treating through a Nevirapine rash? If a rash is severe what is the probability of rash with Efavirenz?...

Response from Keith Henry, M.D.

University of Minnesota, School of Medicine

Treating through a NVP rash is possible when it is mild and in not accompanied by mucosal involvement (eyes, mouth/lips), systemic complaints (fever, severe malaise), or evidence for hepatic inflammation. In both our clinic and in research trials... Read more »

From Efivarenz to nevirapin

Hi Doc. My husband and I are planning to have a baby. I am on Efivarenz and Lamzid currently. How will switching to nevirapine affect my viral load? Currently it's undetectable. Can I switch back to efivarenz once baby is born? How long should...

Response from Keith Henry, M.D.

University of Minnesota, School of Medicine

If you are well suppressed on an efavirenz containing regimen with no prior history of drug failure (viral resistance) then switching to nevirapine has a high rate of success in maintaining suppression of HIV replication. After delivery patients... Read more »

switching nevirapine with efavirenz after 2 weeks from PEP

i have been treated with PEP after 12 hours of possible exposure. i was having sex with a girl and the condom broke. i was been treated with combivir+nevirapine and after 2 weeks i changed nevirapine to efavirenz because of the rash caused by the...

Response from Joseph McGowan, M.D., F.A.C.P.

North Shore University Hospital

Please let me provide you with some reassurance. First, you were using condoms which substantially reduces your HIV exposure risk. Second, you were placed on post exposure prophylaxis (or PEP) very promptly (within 12 hours of the exposure). PEP is... Read more »

Nevirapine with HCV History

Due to development of sensitive (painful)pronounced gynecomastia caused by efavirenz (taken in conjunction with abacavir & stavudine), we have opted to modify my protocol by replacing the efavirenz with nevirapine. I have a history of HCV...

Response from Brian Conway, M.D.

University of British Columbia

The switch you are contemplating is safe as long as your CD4 count is below 400 (if you are male) or 250 (if you are female). Below those levels, the risk of severe hepatic toxicity associated with nevirapine is extremely low. The HCV infection... Read more »

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