What Does Fosamprenavir Do

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Fosamprenavir (Telzir, Lexiva)

What Is Fosamprenavir? Fosamprenavir is a drug used for antiretroviral therapy (ART). It is also called Lexiva TM . In some countries, it is called Telzir. It is manufactured by ViiV Healthcare. Fosamprenavir is a pro-drug. The drug you swallow is not active against HIV. It breaks down in the body to produce the active form, which is the drug amprenavir (see Fact Sheet 445 ). Fosamprenavir is a protease inhibitor. These drugs prevent the...

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fosamprenavir and tenofovir interaction

Is there any drug-drug interactions that you know of between the new PI- fosamprenavir and tenofovir?...

Response from Benjamin Young, M.D., Ph.D.

Rocky Mountain CARES

Thanks for your question.We have very good data about the one-way interaction-- there's no significant change in fosamprenavir's levels when dosed with tenofovir. This is different that the situation for another new PI, atazanavir. When... Read more »

Fosamprenavir?

Hi Dr. Young,Not too long ago, i read fosamprenavir had gone through clinical trials, successfully. It appears to have great efficacy, little side effects (especially for a PI) and the once daily protocol is favorable. Why hasn't it hit the...

Response from Benjamin Young, M.D., Ph.D.

Rocky Mountain CARES

Fosamprenavir (or 908) is a new HIV protease inhibitor (the follow up to the potent, but unwieldly amprenavir (Agenerase). The maker of fosamprenavir, GlaxoSmithKline has submitted paperwork to the US FDA for review; I expect that we will hear from... Read more »

Tenefovir, Emtriva and Fosamprenavir for wild type virus

Would Teneforvir, Emtriva and Fosamprenavir(not boosted with Retonavir) be a potent combo for myself who is found to carry wild type virus? The present regimen includes Kaletra and Retonavir which is giving me endless GI problems. I am...

Response from Benjamin Young, M.D., Ph.D.

Rocky Mountain CARES

Thanks for your post.Though not (yet) formally tested, the combination of tenofovir (Viread), FTC (Emtriva; also available in combination with tenofovir as Truvada) with unboosted fosamprenavir (Lexiva, Telzir) should be quite well tolerated.A... Read more »

fosamprenavir+/- ritovavir

Quick question I am treatment naive but about to start drug therapy. I have the option to take fosamprenavir alone (at a higher dose) or at a reduced dose with ritonavir. I read that boosting with ritonavir from the start might prevent resistance....

Response from Keith Henry, M.D.

University of Minnesota, School of Medicine

The period of greatest risk for resistance is often the first year on therapy. In order to avoid early resistance I usually use a boosted protease inhibitor (with ritonavir) until the viral load is undetectable (< 50 copies)-then I assess whether... Read more »

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Abbott pharmaceuticals price gouging protease inh

Posted by BabyPeanut

Editorial, The Center for AIDS (12/15/03)

In a move that startled healthcare professionals and community members alike, Abbott pharmaceuticals announced a price increase of almost 500% for its protease inhibitor ritonavir (Norvir). Norvir is widely... Read more »

What should I think?

Posted by motherinlaw, 9 Replies

I will try not to make this too long...my son called yesterday and told me his wife was not doing well. My HIV negative son and three HIV negative grandchildren may soon lose their HIV positive wife and mother.
My son and daughter-in-law seem not to... Read more »

information

Posted by Anonymous, 1 Reply

Exploring: NIAID, NIH, U.S. DHHS

March 2005
HIV Infection and AIDS: An Overview
INTRODUCTION
AIDS (acquired immunodeficiency syndrome) was first reported in the United States in 1981 and has since become a major worldwide epidemic. AIDS is caused by HIV... Read more »

Thanks for your support and any more advice?

Posted by motherinlaw, 3 Replies

I want to thank everyone for their support and help. I posted this in response to my own previous posting and felt it might have gotten lost in the shuffle and so am reposting.

I have just spoken to my son again. He was finally able to convince his... Read more »

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