What Does Didanosine Treat

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Get the Facts

Didanosine (Videx, ddI)

What Is Didanosine? ddI (Videx) is a drug used as part of antiretroviral therapy (ART). It is manufactured by Bristol-Myers Squibb and by Barr Laboratories. Didanosine is also known as ddI or dideoxyinosine. Generic versions have been tentatively approved under PEPFAR (see Fact Sheet 475 ). Didanosine is a nucleoside analog reverse transcriptase inhibitor, or nuke. These drugs block the reverse transcriptase enzyme. This enzyme changes HIV's...

Ask the Experts

zidovudine, didanosine, kaletra

Is the above combination suitable for one considered to be resistant to combivir and effavirenz? I have come across these in the internet. My doctor thinks I could be resistant to combivir and effavirenz. I have been on them for 2 years. Due to...

Response from Robert J. Frascino, M.D.

The Robert James Frascino AIDS Foundation

Hello,Ideally speaking, if resistance develops to a HAART (highly active antiretroviral therapy) regimen, I recommend getting a resistance test to help guide the choice of the next regimen. If resistance testing is not an option in Zimbabwe and your... Read more »

DIDANOSINE - 3rd time enquiring!

This is my 3rd time asking this forum.Please do let me know if ddI (didanosine) chewable tablets could be taken once daily basis ? My weight is below 60 kg. so could I take 3 tabs at a time?...

Response from Judith A. Aberg, M.D.

Washington University, St. Louis School of Medicine

I just answered your first request but I am responding again because you have more information this time regarding your weight. Videx (DDI) needs to dosed according to weight and kidney function. Assuming your kidney function is normal, the dose of... Read more »

DIDANOSINE

Could ddI chewable tablets be taken once a day?...

Response from Judith A. Aberg, M.D.

Washington University, St. Louis School of Medicine

Yes, but only the 200 mg tablet can be used because of the amount of buffer in the tablet. Videx does come in a new capsule formulation which is made for once daily dosing. Unless you have difficulty swallowing capsules, you may want to consider... Read more »

Tenofovir & Didanosine Dosing

Could you clarify what you think are reasonable dosages for tenofovir and didanosine when taken in combination? My friend was on 400mg daily didanosine EC (2hr after meal)and 300mg daily tenofovir with meal and was recently switched to combined...

Response from Brian Boyle, M.D., J.D.

Cornell University, Weill Medical College

The data on how to adjust Videx (didanosine) when given with Viread (tenofovir) is not yet available, but there are studies currently underway to provide further guidance. If the patient is going to stay on this combination, adjustment of the Videx... Read more »

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Early HIV Treatment Failure Linked to Didanosine/T

Posted by TwinsDad, 1 Reply

NEW YORK (Reuters Health) Aug 23 - The combination of the antiretroviral agents didanosine, tenofovir, and efavirenz is associated with a high virological failure rate in treatment-naive patients with HIV, British investigators report.

Dr. Desmond... Read more »

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