What Does Darunavir Treat

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Darunavir (Prezista)

What Is Darunavir? Darunavir is a drug used as part of antiretroviral therapy (ART). It is also called Prezista TM and used to be called TMC114. It is manufactured by Tibotec Pharmaceuticals. Darunavir is a protease inhibitor. These drugs prevent the protease enzyme from working. HIV protease acts like a chemical scissors. It cuts the raw material for HIV into specific pieces needed to build a new virus. Protease inhibitors "gum up" these...

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Co administration of darunavir and Atazanavir

Dr Dr,I have been on this regimen (1200 mg Prezista + 100 mg norvir and 300 mg Reyataz) for more than 2 years. I was told by many people that this regimen is not recommended, but my Dr insists it's the best he can give me. Shortly after...

Response from Robert J. Frascino, M.D.

The Robert James Frascino AIDS Foundation

Hi,Dual protease inhibitor (PI) regimens have been used to treat HIV/AIDS; however, the possibility of drug-drug interactions must be carefully considered. Drug-drug interaction studies with Prezista (darunavir) have revealed that most other PIs are... Read more »

Darunavir or not to Darunavir + Low WBC

Hi Joe,I have another question for you. I have recently seen my consultant, and he has suggested changing PI's from Atazanavir to Darunavir. He quotes a few studies that suggest additional benefit for DRV. At the moment I'm undetectable on...

Response from Joseph McGowan, M.D., F.A.C.P.

North Shore University Hospital

Michael,Thanks for your questions. Darunavir is now approved for both first line treatment as well as for treatment experienced patients. It is a very potent protease inhibitor, but potency does not seem to be an issue with your regimen since you... Read more »

Darunavir, Ritonavir and Augmentin

I have been prescribed Augmentin for the treatment of bronchitis. Can this be taken with Darunavir and Ritonavir?...

Response from Keith Henry, M.D.

University of Minnesota, School of Medicine

Generally OK to take darunavir/ritonavir with Augmentin. KH... Read more »

darunavir & CNS effects

My BF is on darunavir (among others) - since he has started this drug, he has been experiencing patches of dizziness (he calls it "wonkiness) after taking it. Would this be from the darunavir, or is it more likely to be caused by interactions...

Response from Keith Henry, M.D.

University of Minnesota, School of Medicine

Either the daurunavir or the accompanying ritonavir may be the most likely of his HIV drugs to cause some periods of dizziness. For most patients that complaint stabilizes/settles down after several months. KH... Read more »

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