What Do Fusion Inhibitors Treat

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Fusion and Attachment Inhibitors

Note: Several fact sheets describe drugs that are being tested against HIV: Fact Sheet 410 : nucleoside analog reverse transcriptase inhibitors (nukes) Fact Sheet 430 : non-nucleoside analog reverse transcriptase inhibitors (NNRTIs or non-nukes) Fact Sheet 440 : protease inhibitors Fact Sheet 470 : other antiretroviral drugs in development Fact Sheet 480 : immune therapies These drugs have not been approved by the Food and Drug...

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mechanism of action of fusion inhibitors

how do fusion inhibitor act to treat HIV...

Response from Don Kurtyka, ARNP

University of South Florida School of Medicine

There's a ton of information on thebody.com that describes how fusion inhibitors work. You might want to also check out www.fuzeon.com.If you're more into graphics, check out the video link in this message! It's very cool. <a... Read more »

fusion inhibitors

Is there a pill form of any fusion inhibitors coming soon?...

Response from Don Kurtyka, ARNP

University of South Florida School of Medicine

Fuzeon is the only fusion inhibitor currently approved by the FDA. Fusion inhibitors are part of a bigger classification of drugs called entry inhibitors which also includes attachment inhibitors, CXCR4 inhibitors and CCR5 inhibitors. There are... Read more »

Fusion inhibitors

I would very much like to know if fusion inhibitors are going to produce loss or fat acumulations like protease inh., and if the new Tenofovir has more of these kind of side effects than other transcriptase inhibitors. Thank you...

Response from Keith Henry, M.D.

University of Minnesota, School of Medicine

T-20 (the only fusion inhibitor in wide use) has not been associated with lipodystrophy yet. Since it works extracellularly there is hope that some of those problems associated with unwanted activity of a drug inside cells might be avoided. It... Read more »

Fusion Inhibitors

Can you shed any light on what, if any, of the preliminary reports on fusion inhibitors may include as far as side effects? I guess I am assuming they have done some human trials??...

Response from Keith Henry, M.D.

University of Minnesota, School of Medicine

T-20 = Fuzeon is the only fusion inhibitor soon to be more widely available. Since it acts outside of cells (blocking fusion) its toxicity would be expected to be low and that has been the case in major clinical trials conducted to date. The major... Read more »

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Fusion Inhibitor News?

Posted by Anonymous

Does anyone know if the fusion inhibitor trials (phase III) are going OK, or where to go for an update? Last I heard 700 patients in 100 countries were in the study for T-20(?)
I went to the Trimeris site and didn't see anything new.

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bone density loss due to protease inhibitors

Posted by Anonymous, 1 Reply

Curious as to latest info. on research into bone density loss due to HAART therapy. Most research data i've seen goes back to 99 or 2000. Any new data/research into this? Also any info. on clinical trials currently under way looking into this... Read more »

AbacavirLamivudine to treat HIV infection.

Posted by jenniferdraper

AbacavirLamivudine is used to treat HIV infection. This combination medication is used with other medications. It belongs to a class of drugs known as nucleoside reverse transcriptase inhibitors. Read more »

Entry Inhibitors

Posted by Anonymous, 1 Reply

Does anyone know anything about the new entry inhibitors? I think Pfizer and Schering both have drugs in development. Should we be hopeful? Read more »

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