What Do Fusion Inhibitors Do

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Fusion and Attachment Inhibitors

Note: Several fact sheets describe drugs that are being tested against HIV: Fact Sheet 410 : nucleoside analog reverse transcriptase inhibitors (nukes) Fact Sheet 430 : non-nucleoside analog reverse transcriptase inhibitors (NNRTIs or non-nukes) Fact Sheet 440 : protease inhibitors Fact Sheet 470 : other antiretroviral drugs in development Fact Sheet 480 : immune therapies These drugs have not been approved by the Food and Drug...

Ask the Experts

fusion inhibitors

Is there a pill form of any fusion inhibitors coming soon?...

Response from Don Kurtyka, ARNP

University of South Florida School of Medicine

Fuzeon is the only fusion inhibitor currently approved by the FDA. Fusion inhibitors are part of a bigger classification of drugs called entry inhibitors which also includes attachment inhibitors, CXCR4 inhibitors and CCR5 inhibitors. There are... Read more »

Fusion inhibitors

I would very much like to know if fusion inhibitors are going to produce loss or fat acumulations like protease inh., and if the new Tenofovir has more of these kind of side effects than other transcriptase inhibitors. Thank you...

Response from Keith Henry, M.D.

University of Minnesota, School of Medicine

T-20 (the only fusion inhibitor in wide use) has not been associated with lipodystrophy yet. Since it works extracellularly there is hope that some of those problems associated with unwanted activity of a drug inside cells might be avoided. It... Read more »

Fusion Inhibitors

Can you shed any light on what, if any, of the preliminary reports on fusion inhibitors may include as far as side effects? I guess I am assuming they have done some human trials??...

Response from Keith Henry, M.D.

University of Minnesota, School of Medicine

T-20 = Fuzeon is the only fusion inhibitor soon to be more widely available. Since it acts outside of cells (blocking fusion) its toxicity would be expected to be low and that has been the case in major clinical trials conducted to date. The major... Read more »

FUSION INHIBITORS?

In the news internationally a few weeks ago, was a report on Fusion Inhibitors, and that they are thought to be very promising, and should be available soon. It was reported that they are the most successful treatment to date available. Of course...

Response from Judith Feinberg, M.D.

University of Cincinnati, College of Medicine

Fusion inhibitors are being tested in clinical trials. Depending on the entry criteria for these studies, you may be eligible to participate. They are not necessarily "the best" drugs for HIV, just the newest, and will have to be used... Read more »

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Fusion Inhibitor News?

Posted by Anonymous

Does anyone know if the fusion inhibitor trials (phase III) are going OK, or where to go for an update? Last I heard 700 patients in 100 countries were in the study for T-20(?)
I went to the Trimeris site and didn't see anything new.

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Entry Inhibitors

Posted by Anonymous, 1 Reply

Does anyone know anything about the new entry inhibitors? I think Pfizer and Schering both have drugs in development. Should we be hopeful? Read more »

Hyperglycemia as a result of Protease Inhibitors

Posted by Anonymous

I found a product for reducing glucose levels. It is called Meishan Tea. They make 4 different kinds of tea and I have people that are showing tremendous results on all 4 kinds. However, the people that are presently taking the tea do not have AIDS.... Read more »

lipodystrophy from protease inhibitors

Posted by Anonymous, 4 Replies

I have known about my HIV+ status now for 6 years, and God has blessed me with continued good health. I have accessed all the major medications, plus vitamins to help fight the disease. Once I started taking the new protease inhibitors, I started... Read more »

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