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What Do NRTIs Do

Here's a taste of what has to offer on this topic:
Ask the Experts

Off label use of NRTIs for obesity

Hi there doctor,Thanks for this fantastic web site and the work you do.Out of curosity, with the focus on NRTIs, esp. the D-drugs and azt on fat loss, has there been any discussion of using this category of drugs off-label to treat obese or...
Keith Henry, M.D.

Response from Keith Henry, M.D.

University of Minnesota, School of Medicine
NRTIs are generally expensive with a wide range of potential mild or serious side effects. The effect on fat resulting in fat loss is believed to be due partly to fat cell death possibly linked to mitochondrial toxicity which has potentially serious... Read more »

Resitant to all PIs & almost all NRTIs

Hello,I have been HIV+ for 25 years and have done pretty well on my HIV therapies which I began... Read more »

Sustiva causing resistance to other nNRTIs

Sustiva (efavirenz)-Induced Mutation in Subtype C HIV May Confer Multi-NNRTI ResistanceA mutation... Read more »
Seattle Treatment Education Project

Know Your HIV Drugs: NRTIs (The Nukes)

In recent years the drug choices available to people with HIV have increased substantially. There are currently 16 approved antiviral drugs for HIV and these drugs are usually used in combinations of three or more to create an effective antiviral... Read more »
HIV i-Base

ARVs and Bone Health: The Role of NRTIs in Second-Line Therapy

The final clinical late-breaker oral presentation at IAS 2013 reported significantly less reduction in bone mineral density (BMD) after a year on an NRTI-sparing combination in a randomised study compared to standard NRTI-containing treatment. 1 ... Read more »
Project Inform

Nukes? Or No Nukes?

While specific drugs have fallen in and out of favor, the basic structure of anti-HIV therapy -- called HAART -- has changed very little since the late 1990s. Almost all regimens include one highly potent drug -- either a boosted protease inhibitor... Read more »
U.S. Centers for Disease Control and Prevention

AIDS Drugs Can Cause Premature Aging: Study

A class of AIDS drugs has been linked with mitochondrial DNA mutations, which could help explain the premature aging and age-related illnesses seen in some HIV patients, British researchers say in a new study. The implicated class, nucleoside analog... Read more »
Connect With Others

Drug Resistant HIV

Posted by Anonymous

I just found out the strain of hiv i have is resistant to possibly a whole class of NRTIs and PIs..any experience with this for any of you? what could the options be for someone in my situation? I am still treatment naive.

Read more »

Picking treatment

Posted by Anonymous, 3 Replies
I have to pick my treatment now (positive for 8 years and only now do I need treatment cause viral load went up and tcells went down)and I'm not sure what to do. Any suggestions for first choice of therapy...I heard sustiva with two nrtis would be... Read more »

Entry Inhibitors

Posted by Anonymous, 1 Reply
Does anyone know anything about the new entry inhibitors? I think Pfizer and Schering both have drugs in development. Should we be hopeful? Read more »

want to have a baby, but worried

Posted by kolo, 1 Reply
quote: Adam Legge, Monday, April 16, 2007
Antiretroviral drugs used to prevent HIV transmission from mother to child can cause genetic damage in infants that may increase their risk of developing cancer in the future, according to new research.

The... Read more »