What Are The Side Effects Of Didanosine

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Didanosine (Videx, ddI)

What Is Didanosine? ddI (Videx) is a drug used as part of antiretroviral therapy (ART). It is manufactured by Bristol-Myers Squibb and by Barr Laboratories. Didanosine is also known as ddI or dideoxyinosine. Generic versions have been tentatively approved under PEPFAR (see Fact Sheet 475 ). Didanosine is a nucleoside analog reverse transcriptase inhibitor, or nuke. These drugs block the reverse transcriptase enzyme. This enzyme changes HIV's...

Ask the Experts

DIDANOSINE - 3rd time enquiring!

This is my 3rd time asking this forum.Please do let me know if ddI (didanosine) chewable tablets could be taken once daily basis ? My weight is below 60 kg. so could I take 3 tabs at a time?...

Response from Judith A. Aberg, M.D.

Washington University, St. Louis School of Medicine

I just answered your first request but I am responding again because you have more information this time regarding your weight. Videx (DDI) needs to dosed according to weight and kidney function. Assuming your kidney function is normal, the dose of... Read more »

Tenofovir & Didanosine Dosing

Could you clarify what you think are reasonable dosages for tenofovir and didanosine when taken in combination? My friend was on 400mg daily didanosine EC (2hr after meal)and 300mg daily tenofovir with meal and was recently switched to combined...

Response from Brian Boyle, M.D., J.D.

Cornell University, Weill Medical College

The data on how to adjust Videx (didanosine) when given with Viread (tenofovir) is not yet available, but there are studies currently underway to provide further guidance. If the patient is going to stay on this combination, adjustment of the Videx... Read more »

neuropathy pain (didanosine+stavudine+efavirenz)

Dear Dr Robert J. Frascino, I'm sure many patients email you a lot of times regarding this matter. But I really really hope you won't get bored. I'd really really appreciate your help, time and patience!My question is:My father CD4...

Response from Robert J. Frascino, M.D.

The Robert James Frascino AIDS Foundation

Hi Tom,Didanosine (ddI) plus stavudine (d4T) is no longer a recommended combination! It has been found to be less effective and substantially more toxic than many other nucleoside combinations, such as AZT/3TC or Viread/FTC, for example. The ddI... Read more »

DIDANOSINE

Could ddI chewable tablets be taken once a day?...

Response from Judith A. Aberg, M.D.

Washington University, St. Louis School of Medicine

Yes, but only the 200 mg tablet can be used because of the amount of buffer in the tablet. Videx does come in a new capsule formulation which is made for once daily dosing. Unless you have difficulty swallowing capsules, you may want to consider... Read more »

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Connect With Others

Early HIV Treatment Failure Linked to Didanosine/T

Posted by TwinsDad, 1 Reply

NEW YORK (Reuters Health) Aug 23 - The combination of the antiretroviral agents didanosine, tenofovir, and efavirenz is associated with a high virological failure rate in treatment-naive patients with HIV, British investigators report.

Dr. Desmond... Read more »

wasting

Posted by Anonymous, 1 Reply

This wasting issue is certainly confusing. Ive just read an answer where the doctor said that d4t and ddi are associated with this problem, and so Ive heard from some sero+ people. Others say is because of protease inhibitors, and others say is a... Read more »

Liver Function

Posted by NYRN, 1 Reply

I'm taking viread, invirase, didanosine, zidovudine and valtrex and my latest labs indicate high on the liver screens. Has anyone had any liver issues - I don't drink so it's not that! Read more »

Urge segunda opinion

Posted by Edy, 1 Reply

El problema es que me hicieron un genotipo y segun el resultado sali resistente a:
Efavirenz
Nevirapine
Lamivudine
Didanosine
Abacavir
Emtricitabine

Mi doctora me pinto un panarama muy pesimista y medijo que solo tengo una opcion de esquema:... Read more »

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