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What Are The Mechanisms Of HIV-1 Resistance On Protease Inhibitors Therapy?

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AIDS InfoNet

Protease Inhibitors in Development

These drugs have not been approved by the Food and Drug Administration (FDA) for use against HIV. Protease Inhibitors These drugs block the protease enzyme. When new viral particles break off from an infected cell, protease cuts long protein strands into the parts needed to assemble a mature virus. When protease is blocked, the new viral particles cannot mature. Protease Inhibitors in Development Several firms are trying to develop a new...
Ask the Experts

cryptococcal meningitis Resistant to Protease Inhibitors

What would you advise a patient with CD4s of 8, a Viral Load over 100,000, off therapy for six months because of wasting that may have been caused by meds?weight returned from about 129lbs. to 160lb after stopping Crixivan, Kaletra, Combivir,...
Keith Henry, M.D.

Response from Keith Henry, M.D.

University of Minnesota, School of Medicine
Clearly a tough situation. Maximizing nutrition, maintain good body weight (check testosterone levels),prevention of other opportunistic infections, aggressive use of amphotericin--those treatments can often maintain a person's health. There... Read more »

Therapy without a Protease Inhibitor

Viracept was causing erratic diarrhea. My doctor switched me to Kaletra. My combo is currently Kaletra, Videx, Viramune, and Viread.The side effects of the Kaletra are worse than those of the Viracept.Can a combo therapy work without a protease...
Keith Henry, M.D.

Response from Keith Henry, M.D.

University of Minnesota, School of Medicine
Yes many effective regimens are available that don't contain a protease inhibitor. Whether any of those are an option depends heavily on whether you have failed any previous regimens or have a resistance virus. Use of nevirapine(you are... Read more »

HIV protease inhibitors

Could you tell me the spectrum of activity and the mechanism of resistance for the antimicrobial HIV protease inhibitors (Ex: Indinavir)and do they work with gram positve/gram negative bacteria. What bacteria does it work against. Or what sites I...
Eric Daar, M.D.

Response from Eric Daar, M.D.

UCLA School of Medicine
The HIV protease inhibitor selectively blocks the protease enzyme and prevents an infected cell from producing infectious HIV. Resistance develops when mutations emerge in the viral protease enzyme that prevent the inhibitor from interacting with... Read more »

Protease Inhibitors and Living with HIV/AIDS

Just wondering, is there a train of thought that protease inhibitors may ultimately prevent the possibility of AIDS occuring and basically have people living with HIV for an entire lifetime? Upon initially beginning treatment for hiv is it possible...
Rick Sowadsky, M.P.H.

Response from Rick Sowadsky, M.P.H.

Nevada State Health Division AIDS Program
Thank you for your questions.When it comes to the protease inhibitors and other antiviral therapies, there is good news and bad news.The good news:1) Treatments have been shown to significantly improve the quantity of a persons life. People taking... Read more »
Connect With Others

lipodystrophy from protease inhibitors

Posted by Anonymous, 4 Replies
I have known about my HIV+ status now for 6 years, and God has blessed me with continued good health. I have accessed all the major medications, plus vitamins to help fight the disease. Once I started taking the new protease inhibitors, I started... Read more »

bone density loss due to protease inhibitors

Posted by Anonymous, 1 Reply
Curious as to latest info. on research into bone density loss due to HAART therapy. Most research data i've seen goes back to 99 or 2000. Any new data/research into this? Also any info. on clinical trials currently under way looking into this... Read more »

Protease Inhibitors - Hemophilia bleeds

Posted by akcol
Hi, my fiance is a Long Term NonProgressor - 24 years positive, co-infection HCV, with severe Hemophilia A.

This is a question for the gentlemen with Hemophilia please.
We're requesting any input about any Hemophilic PI increased unusual bleed... Read more »

Resisting Resistance - A Story

Posted by Survivor, 1 Reply
Personal Perspective: Resisting Resistance

By Matt Sharp

Spring 2006

In a little over four months I will turn fifty. When I was diagnosed with HIV in 1988 I never dreamed I'd reach forty. I've survived a long battle with HIV, and it has not been... Read more »