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What Are The Dangers Of Stavudine

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AIDSinfo

An Overview of Zerit (Stavudine, d4T)

... STAV-yoo-deen Brand Name: Zerit Other Name(s): BMY-27857, Estavudina, d4T Drug Class: Nucleoside Reverse Transcriptase Inhibitors Stavudine, also known as Zerit or d4T, is a type of medicine called a nucleoside reverse transcriptase inhibitor (NRTI). Stavudine works by disrupting one of the early steps in the HIV life cycle, called reverse transcription. During normal
Ask the Experts

Can I take Zerit (Stavudine, d4T) with Viread (Tenofovir).

Hi, I just had a quick question. I've been researching everywhere but couldnt find an answer, if I'm taking Zerit (Stavudine, d4T) and Sustiva (Efavirenz, Stocrin), can I take Viread (Tenofovir).Thanks so much for all your help. God bless.
Benjamin Young, M.D., Ph.D.

Response from Benjamin Young, M.D., Ph.D.

Rocky Mountain CARES
...Hello and thank you for your post.While d4T (Zerit) is not routinely used with tenofovir (Viread, Truvada),nor is this a commonly used NRTI backbone to be taken with efavirenz, Read more »

d4t to AZT

I have suffered severe lipoathrophy, i tested positive in june 2005.iwas immediately placed on Stavudine, neviripine and lamuvidine. i did quite well and later started noticing that i lost muscles and fat on my thighs, buttocks, arms, and legs and...
Keith Henry, M.D.

Response from Keith Henry, M.D.

University of Minnesota, School of Medicine
...There has been little published about what happens to peripheral fat when D4T is switched to AZT. AZT generally has a milder effect on peripheral fat so some patients may note a slow increase after the Read more »

What can I switch to after stopping d4t

Hi there,I have been on stavudine,lamuvidine and efavirenz for the past 4 yrs and have noticed that I have lost fat on my arms,legs and accumulated fat on my stomach,I am thinking of switching the d4t and wonder what is the best nucleoside analog...
Keith Henry, M.D.

Response from Keith Henry, M.D.

University of Minnesota, School of Medicine
...When a patient is experiencing fat loss on D4T then the situation may be stabilized by switching to a non-thymidine analogue such as abacavir or tenofovir. Stabilizaton or Read more »

neuropathy pain (didanosine+stavudine+efavirenz)

Dear Dr Robert J. Frascino, I'm sure many patients email you a lot of times regarding this matter. But I really really hope you won't get bored. I'd really really appreciate your help, time and patience!My question is:My father CD4 recently = 480He...
Robert J. Frascino, M.D.

Response from Robert J. Frascino, M.D.

The Robert James Frascino AIDS Foundation
...Hi Tom,Didanosine (ddI) plus stavudine (d4T) is no longer a recommended combination! It has been found to be less effective and substantially more toxic than many other Read more »
Articles
Test Positive Aware Network

La Guía Annual de Medicamentos para el VIH: Zerit (Stavudine, d4T)

...   Nombre de Marca: Zerit Nombre Común: stavudine o d4T Clase: nucleósido análogo (también llamado inhibidor de la transcriptasa reversa del nucleósido, NRTI, siglas en Read more »
The Body PRO

Efavirenz (EFV) in Combination with Stavudine (D4T) and Didanosine (DDI) or Lamivudine (3TC) Is Well-Tolerated and Efficacious in the Majority of Patients Treated

...also called Sustiva. The original study used AZT plus 3TC -- here the investigators studied Sustiva in combination with either d4T plus 3TC, as well as d4T with ddI. Both studies enrolled just over 60 people. The d4T/3TC study presented data... Read more »
The Body PRO

Abstract No. 420: A Phase I Study of Hydroxyurea in HIV-Infected Children Receiving Didanosine (ddI) and/or Stavudine (d4T)

...Medicine, evaluated the safety, antiviral and immunologic effects, and pharmacokinetics of hydroxyurea, given with ddI and/or d4T to symptomatic HIV-infected children. It is among the first to look at the use of HU in children. The children... Read more »
International Association of Physicians in AIDS Care

A Note to Physicians: Important Information on the Combination of Zidovudine (ZDV) and Stavudine (d4T) in ZDV-experienced HIV-Infected Patients

...weeks. An interim analysis of this study revealed that the average CD4+ T cell count in patients taking the combination of d4T and ZDV decreased from the time they entered the study. NIAID recommends that physicians closely monitor the CD4+ T... Read more »
Connect With Others

50% of HIV+ Develop Neurocognitive Impairment

Posted by ScotCharles, 3 Replies
...to the kinds of specific treatments they received, such as a type of drug called the "D" drugs [didanosine (ddI, Videx) and stavudine (d4T, Zerit)]. Coming back to the brain involvement, we also tried to look at [whether there are] some things... Read more »

Bristol Myers Squibbs: Videx

Posted by Anonymous, 2 Replies
Gentlemen, Stay away from Videx it infected my pancreas and made me diabetic, apprantly it does that to a high percentage of people on it or as I also understand kills another hign percentage of them. What does Bristol Myers Squibbs do? Sell death... Read more »

HIV / AIDS DOCS

Posted by Survivor, 1 Reply
...Suprunenko: AZT [zidovudine, Retrovir], 3TC [lamivudine, Epivir] and efavirenz [Sustiva, Stocrin]. [Lavra also provides d4T (stavudine, Zerit), ddI (didanosine, Videx), nevirapine (Viramune), nelfinavir (Viracept) and lopinavir/ritonavir... Read more »

What should I think?

Posted by motherinlaw, 9 Replies
I will try not to make this too long...my son called yesterday and told me his wife was not doing well. My HIV negative son and three HIV negative grandchildren may soon lose their HIV positive wife and mother. My son and daughter-in-law seem not to... Read more »