What Are The Dangers Of Maraviroc

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Get the Facts

Maraviroc (Selzentry, Celsentri)

What Is Maraviroc? Who Should Take It? What About Drug Resistance? How Is Maraviroc Taken? What Are the Side Effects? How Does It React With OtherDrugs? The Bottom Line What Is Maraviroc? Maraviroc (Selzentry in the US and Celsentri elsewhere) was formerly known as UK 427,857. It is a drug used for antiretroviral therapy. It is manufactured by ViiV Healthcare. Maraviroc is the first "attachment inhibitor" drug. When HIV...

Ask the Experts

Maraviroc

My viral load has become detectable and my doctor would like to put me on Maraviroc and Isentress. I have been reviewing both of these drugs and I have some concerns with Maraviroc. I know it works on the CCR5 but what is known about the CCR5...

Response from Joseph McGowan, M.D., F.A.C.P.

North Shore University Hospital

The CCR5 receptor is a receptor on the CD4 T cell. It is used as a 2nd (or co-) receptor for HIV to enter the T cell. HIV may also use another co-receptor (called CXCR4) to enter the cell. Since maraviroc only blocks virus that use CCR5, it is... Read more »

maraviroc

hi drgood morninghope all is well on your side.i am a male of 30 newly diagnosed with hiv during a blood donation camp.in couple of days my lab results for cd4 and viral load will be out and i will see an hiv specialist for the drug regimen.i read...

Response from Keith Henry, M.D.

University of Minnesota, School of Medicine

There is comparativey little info about use of CCR5 inhibitors like maraviroc for initial treatment of HIV infection. Since the success rates for initial therapy with current often simple (once daily ) regimens is now fairly high (often > 90%)... Read more »

Taking Maraviroc

Hello,im now taking crixivan, combivir and bactrim daily..my CD4 around 100 and viral load 6000+my doc suggest me to change my treatment to maraviroc..is it maraviroc suitable for Hep-C/Heamophilia patient with HIV?and what ur suggestion?...

Response from Eric Daar, M.D.

UCLA School of Medicine

Thank you for your post. It is very unusual in the current era to find someone on crixivan with NRTIs in your situation. Clearly if you are taking your medications and have detectable viral load on this regimen you should have drug resistance... Read more »

Maraviroc as PrEP?

Hello,couldn't be Maraviroc a proper PrEP as the virus is usually CCR5 tropic, when people are first infected?...

Response from Benjamin Young, M.D., Ph.D.

Rocky Mountain CARES

Hi and thanks for posting.In theory, you're correct. It would make sense to try to block HIV entry into cells- CCR5 blockers would do just that. For the same reason, some have advocated the use of integrase inhibitors, to prevent... Read more »

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