What Are Some Causes Of Hepatotoxicity

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Hepatotoxicity

Terms Used in This Fact Sheet Enzyme: a special protein that speeds up chemical reactions. Liver function tests (LFTs): tests that measure the blood levels of liver enzymes (proteins made and used by the liver) to determine if your liver is... Read more »

U.S. Centers for Disease Control and Prevention

Adverse Events for PEP Attributed to Nevirapine

In September 2000, two instances of life-threatening hepatotoxicity were reported inhealth-care workers taking nevirapine (NVP) for postexposure prophylaxis (PEP) afteroccupational human immunodeficiency virus (HIV) exposure* . In one case, a... Read more »

Overlapping Epidemics: TB, HIV and Viral Hepatitis

Disturbing reports of overlapping TB, HIV, and viral hepatitis epidemics emerged at the 2005 International AIDS Society Conference. In the newly independent states of Eastern Europe and Central Asia, HIV incidence continues to rise, and viral... Read more »

Ask the Experts

ANTIRETROVIRAL HEPATOTOXICITY

CAN KALETRA,DDI AND D4T CAUSE SEVERE HEPATOTOXICITY, IN A PATIENT WITH HEPATITIS C CONINFECTION? IF YES, WHAT KIND OF HEPATIC DAMAGE? ...

Response from Keith Henry, M.D.

University of Minnesota, School of Medicine

Yes those drugs can either individually or in combination cause a form of drug induced hepatitis that would be more common inpatients with hepatitis C infection. Among the protease inhibitors ritonavir has been most associated with drug induced... Read more »

REYATAZ, WHAT ARE ITS "WORSENING" / HEPATOTOXIC EFFECTS ?

dear dr. d good day and good health ! can you state with specificity what effect(s) short-/longterm administration of reyataz (atazanavir) can have on active untreated hbv in a coinfected patient ? the reyataz patient info leaflet states : reyataz...

Response from Keith Henry, M.D.

University of Minnesota, School of Medicine

I have used atazanavir in a number of hepatitis B infected patients without any problem. Atazanavir can cause an increase in indirect bilirubin levels (Like Gilbert's syndrome) which has not yet been demonstrated to actually cause any liver... Read more »

REYATAZ, WHAT ARE ITS "WORSENING" / HEPATOTOXIC EFFECTS ?

dear dr. d good day and good health !can you state with specificity what effect(s) short-/longtermadministration of reyataz (atazanavir) can have on active untreated hbvin a coinfected patient ?the reyataz patient info leaflet states :reyataz can...

Response from Douglas T. Dieterich, M.D.

New York University, School of Medicine

You should certainly be treating your HBV along with your HIV. It is very convenient now with 3TC, FTC, and tenofovir which are all active against HBV. Reyataz can cause increased bilirubin or jaundice if you have liver disease. However, while this... Read more »

HIV positive and Hepatitis B or C concern

My friend has taken D4T40,3TC and NVP for four months,now his ALT increased from 76 to 195.Does he need to change the regime as It is the concerning of Hepatitis B?...

Response from Barbara McGovern, M.D.

Tufts University School of Medicine

There are three main possibilities:1. It is possible that nevirapine may be causing some irritation of the liver - what we call "drug-induce liver injury" or "hepatotoxicity". 2. There is a good immune response to the HIV regimen... Read more »

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Should i Start medication???

Posted by coconyc, 3 Replies

Hi im Coco from nyc I though the benefit or getting tested its to find out the virus in a early time so u can get a good treatment that prolong ur life in a better condition, i got my first results a month ago and i got CD4:276 and VL: 3616, so my... Read more »

U.S. Issues Warning on Use of Anti-AIDS Drug

Posted by Anonymous

Reuters 1/4/01

Atlanta -- Health-care workers who take nevirapine after possible occupational exposure to the AIDS virus risk potentially life-threatening side effects from the anti-AIDS drug, federal health officials said on Thursday.

The Centers for... Read more »

Should I report this HIV doctor?

Posted by BrokenWingedBird, 6 Replies

Hi.

It's six days since I had a bad experience with an HIV doctor. The anger in me has subsided. However, I was so enraged by this doctor at the time that the next day I got in touch with the hospital to find out to whom I should direct a... Read more »

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