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What Are Serine Protease Inhibitors

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Ask the Experts

JAMA article on virus inhibitory peptide

I happened to see a short article in a May issue of JAMA about a natural peptide found in human blood that blocks HIV, considered to be a possible source of a new class of HIV drugs. Can you explain in layman's terms? What point is the research at?
Gerald Pierone, M.D.

Response from Gerald Pierone, M.D.

AIDS Research and Treatment Center of the Treasure Coast
...of a naturally circulating blood protein called alpha-1 anti-trypsin. Alpha-1 anti-trypsin is the most abundant circulating serine protease inhibitor. This peptide was then modified with genetic engineering techniques and this resulted in an... Read more »

Protease Supplements?

I'm on Atripla which I believe contains a protease-inhibitor. You can imagine my consternation... Read more »

Protease Inhibitors with Hep C

I have failed my course of Interfuron therapy. Can you recomend studies going on I could become a... Read more »
Articles
Treatment Action Group

Blockbusters Beckon

...in theory be less effective in people with impaired immune responses due to HIV infection. A New Class of HCV Drugs: Serine Protease Inhibitors Many companies have pursued drugs designed to inhibit the HCV serine protease enzyme, based on the... Read more »
Treatment Action Group

Oral Antivirals: HCV Protease and Polymerase Inhibitors

...The NS3-4A serine protease enzyme and the NS5B RNA-dependent RNA polymerase enzyme are primary targets for oral antiviral agents, since both enzymes are Read more »
Treatment Action Group

References

...conferring resistance to a hepatitis C virus (HCV) RNA-dependent RNA polymerase inhibitor alone or in combination with an HCV serine protease inhibitor in vitro. Antimicrob Agents Chemother . 2005 Oct;49(10):4305-14. Petersen ML, Wang Y, van... Read more »
AIDS InfoNet

Protease Inhibitors in Development

... Protease Inhibitors Protease Inhibitors in Development PIs No Longer in Development NOTE: Several fact sheets describe drugs that are being Read more »
Connect With Others

lipodystrophy from protease inhibitors

Posted by Anonymous, 4 Replies
...good health. I have accessed all the major medications, plus vitamins to help fight the disease. Once I started taking the new protease inhibitors, I started growing breasts and huge amount of fat in the stomache area...infact, my entire torso... Read more »

bone density loss due to protease inhibitors

Posted by Anonymous, 1 Reply
Curious as to latest info. on research into bone density loss due to HAART therapy. Most research data i've seen goes back to 99 or 2000. Any new data/research into this? Also any info. on clinical trials currently under way looking into this... Read more »

Protease Inhibitors - Hemophilia bleeds

Posted by akcol
Hi, my fiance is a Long Term NonProgressor - 24 years positive, co-infection HCV, with severe Hemophilia A. This is a question for the gentlemen with Hemophilia please. We're requesting any input about any Hemophilic PI increased unusual bleed... Read more »

Hyperglycemia as a result of Protease Inhibitors

Posted by Anonymous
I found a product for reducing glucose levels. It is called Meishan Tea. They make 4 different kinds of tea and I have people that are showing tremendous results on all 4 kinds. However, the people that are presently taking the tea do not have... Read more »