What Are Protease Inhibitor Indinavir

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Indinavir (Crixivan)

What Is Indinavir? Indinavir is a drug used as part of antiretroviral therapy (ART). It is also called Crixivan. It is manufactured by Merck & Co. Indinavir is a protease inhibitor. These drugs prevent the protease enzyme from working. HIV protease acts like a chemical scissor. It cuts the raw material for HIV into specific pieces needed to build a new virus. Protease inhibitors "gum up" these scissors. Who Should Take It? Indinavir...

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Minor resistance to Protease Inhibitors (more details)

I wrote to you yesterday regarding my resistance report although I am not on meds. The report was as follows. Potential low level resistance to IDV Protease Inhibitors, all others are susceptible (ie: APV, ATV, LPV, NFV, RTV and SQV) Nucleoside RTI...

Response from Benjamin Young, M.D., Ph.D.

Rocky Mountain CARES

Nick-Thank you for your post, comments and follow up.I don't think that your resistance pattern should prove too significant in the long-term. You have plenty of very reasonable first-line PI options that should work very well.Good luck... Read more »

Abdominal Distention And Swelling From Protease Inhibitors

Dr. Gallant, do protease inhibitors cause abdominal swelling, in partiuclarCrixivan? If so is thiscondition detrimental to one's health and do all PI's cause this condition?Will this side effect subsideonce the drug is removed? As always I...

Response from Joel Gallant, M.D.

Johns Hopkins University, School of Medicine

You are referring to what is popularly called "Crix Belly." I have heard ofit (mostly on the Internet) and have seen it in a small number of mypatients. It doesn't appear to be particularly harmful, but can bedistressing enough... Read more »

Minor resistance of Protease Inhibitors

I am not on meds but have had a resistance report and told me that I have resistance to IDV Protease Inhibitor. Is this a bad thing? All otehr drugs I'm told I am ok with. whats the deal?...

Response from Benjamin Young, M.D., Ph.D.

Rocky Mountain CARES

Thanks for your post.It's difficult for me to be sure exactly what "minor resistance" actually means-- it's true that low levels of genotypic resistance can nearly always be overcome with today's batch of boosted protease... Read more »

HIV protease inhibitors

Could you tell me the spectrum of activity and the mechanism of resistance for the antimicrobial HIV protease inhibitors (Ex: Indinavir)and do they work with gram positve/gram negative bacteria. What bacteria does it work against. Or what sites I...

Response from Eric Daar, M.D.

UCLA School of Medicine

The HIV protease inhibitor selectively blocks the protease enzyme and prevents an infected cell from producing infectious HIV. Resistance develops when mutations emerge in the viral protease enzyme that prevent the inhibitor from interacting with... Read more »

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lipodystrophy from protease inhibitors

Posted by Anonymous, 4 Replies

I have known about my HIV+ status now for 6 years, and God has blessed me with continued good health. I have accessed all the major medications, plus vitamins to help fight the disease. Once I started taking the new protease inhibitors, I started... Read more »

bone density loss due to protease inhibitors

Posted by Anonymous, 1 Reply

Curious as to latest info. on research into bone density loss due to HAART therapy. Most research data i've seen goes back to 99 or 2000. Any new data/research into this? Also any info. on clinical trials currently under way looking into this... Read more »

Hyperglycemia as a result of Protease Inhibitors

Posted by Anonymous

I found a product for reducing glucose levels. It is called Meishan Tea. They make 4 different kinds of tea and I have people that are showing tremendous results on all 4 kinds. However, the people that are presently taking the tea do not have AIDS.... Read more »

Protease Inhibitors - Hemophilia bleeds

Posted by akcol

Hi, my fiance is a Long Term NonProgressor - 24 years positive, co-infection HCV, with severe Hemophilia A.

This is a question for the gentlemen with Hemophilia please.
We're requesting any input about any Hemophilic PI increased unusual bleed... Read more »

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