What Are NNRTIs Used For

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Ask the Experts

NNRTIs

Are either of the newer NNRTIs, Edurant or Intelence processed differently by the liver than the older drug Viramune? I have been on Viramune for more than 10 years just wondering of switching to one of the newer ones would be considered more...

Response from Keith Henry, M.D.

University of Minnesota, School of Medicine

The major liver concern with nevirapine is early on treatment. After 10 years the rate of liver problems on nevirapine would be expected to be low. Though etravirine and rilpivirine may be viewed as being more liver friendly there is minimal very... Read more »

Sustiva causing resistance to other nNRTIs

Sustiva (efavirenz)-Induced Mutation in Subtype C HIV May Confer Multi-NNRTI ResistanceA mutation... Read more »

Response from Benjamin Young, M.D., Ph.D. »

NNRTIs and lipitor

What is your feeling about Lipitor to lower cholesterol in patients on nnrti regimens? I've... Read more »

Response from Mark Holodniy, M.D., F.A.C.P., C.I.C. »

Go to Ask the Experts »

Articles

Know Your HIV Drugs: NNRTIs

Non-Nucleoside Reverse Transcriptase Inhibitors (NNRTIs) NNRTIs are another class of FDA-approved HIV antiviral drugs. There are currently three drugs approved for use in this class. NNRTIs work by targeting the structure of reverse transcriptase... Read more »

Drug Watch: Next-Generation NNRTIs: Etravirine and Rilpivirine

Why Do We Need More NNRTIs? Leading the Next Generation: Etravirine and Rilpivirine Etravirine: The DUET Studies Rilpivirine Implications for Treatment Selected Sources Even in patients with the most resistant virus, our goal now is full... Read more »

NNRTIs: The Next Generation Approaches

Part I Introduction Mechanisms of NNRTI Activity and HIV NNRTI Resistance NNRTI Resistance in NNRTI-Naive and NNRTI-Experienced Individuals NNRTI Mutations: Resistance and Cross-Resistance NRTI Mutations: The Potential Impact on NNRTIs NNRTI... Read more »

Two New NNRTIs Enter the Pipeline

Data on two novel NNRTIs were presented at today's late-breaker session at the International AIDS Conference in Mexico City. After years with little development for this important class of HIV treatments, news on two somewhat promising compounds is... Read more »

Connect With Others

Lab, med change, confusion

Posted by kaplan08, 2 Replies

Labs of last year have shown a vload range between <400 and 793, with <400 being most recent; CD4 percentage range from 31% to 34%, with 33% being most recent. Taking only Viramune and Combivir -a test has recently shown resistance to... Read more »

Entry Inhibitors

Posted by Anonymous, 1 Reply

Does anyone know anything about the new entry inhibitors? I think Pfizer and Schering both have drugs in development. Should we be hopeful? Read more »

Protease Inhibitors - Hemophilia bleeds

Posted by akcol

Hi, my fiance is a Long Term NonProgressor - 24 years positive, co-infection HCV, with severe Hemophilia A.

This is a question for the gentlemen with Hemophilia please.
We're requesting any input about any Hemophilic PI increased unusual bleed... Read more »

Re: Something uplifting

Posted by SA_Intellect, 3 Replies

The link below is the response one of the doctors on The Body posted to my question. Read it. It's very positive and will hopefully add a bit of peace to some your hearts.

http://www.thebody.com/Forums/AIDS/TreatExp/Archive/Pipeline/Q173719.html Read more »

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