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Tenofovir And Renal Dosing

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AIDS InfoNet

Tenofovir (Viread)

What Is Tenofovir? Tenofovir (Viread), also called bis-POC PMPA, is a drug used as part of antiretroviral therapy (ART). It is manufactured by Gilead Sciences. The FDA approved tenofovir for use against HIV in October 2001. Generic versions have been tentatively approved under PEPFAR (see Fact Sheet 475 ). Tenofovir is a nucleotide analog reverse transcriptase inhibitor, or nuke. These drugs stop HIV from multiplying by preventing the reverse...
Ask the Experts

Tenofovir and Renal Toxicity, If/when to change?

I have been taking tenofovir (+emtricitabine/sustiva for nearly 6 years. It was my first antiviral regimen and has been highly effective with undetectable viral load since beginning therapy. Had been positive for nearly 20 years and was fortunate...
Keith Henry, M.D.

Response from Keith Henry, M.D.

University of Minnesota, School of Medicine
Good set of questions for which definitive answers are not available. The modest increase in creatinine needs also be be associated with the GFR rate and further changes over next several years (including changes in urine protein and other... Read more »

Tenofovir-Posible dao Renal

Hola Doctor: Estoy tomando Tenofovir-3TC-Kaletra desde hace 5 aos. Carga Indetectable, CD4 = 1006, 32%. Mi pregunta se refiere a un posible dao renal que se este produciendo. En estos aos, lo exmenes de Creatinina en sangre siempre rondaron entre 1...
Steven M. Natterstad, M.D.

Response from Steven M. Natterstad, M.D.

Frascino Medical Group
Hola, La Argentina.Un examen de creatinina que ha aumentado desde 1, primero hasta 1.3, y ms recientemente hasta 1.5 junto con un examen de orina que demuestra proteinuria debe hacerte pensar seriamente en tenofovir como el responsable. Ni el... Read more »

Renal parenchymal disease

Hi Edwin,First: increased creatine levels.Second: Ultrasound says:Increased renal parenchymal echogenicity with an associated decreased corticomedullary ratio consistent with renal parenchymal disease.Me podras explicar?He estado tomando por 7 aos...
Edwin DeJesus, M.D., F.A.C.P.

Response from Edwin DeJesus, M.D., F.A.C.P.

Hi Moises. (First, I am very sorry I missed your question until today a technical issue.)So, I do not have much information about your overall medical history, which is extremely important when evaluating reasons for kidney disease; for example... Read more »

Tenofovir & Didanosine Dosing

Could you clarify what you think are reasonable dosages for tenofovir and didanosine when taken in combination? My friend was on 400mg daily didanosine EC (2hr after meal)and 300mg daily tenofovir with meal and was recently switched to combined...
Brian Boyle, M.D., J.D.

Response from Brian Boyle, M.D., J.D.

Cornell University, Weill Medical College
The data on how to adjust Videx (didanosine) when given with Viread (tenofovir) is not yet available, but there are studies currently underway to provide further guidance. If the patient is going to stay on this combination, adjustment of the Videx... Read more »
Connect With Others


Posted by Anonymous, 1 Reply
I'm just starting treatment and my doctor who does things differently recommended tenofovir...I know it's a new drug. Has anyone any experience with it?

Read more »

HIV testing while on tenofovir.

Posted by EmeandEme, 1 Reply
I have been taking tenofovir for over 6 months for Hep B. 3 months ago I had unprotected sex because the condom broke and need to figure out what test I need to take to check for HIV.

I have gotten tested every single month and everything has come... Read more »


Posted by Anonymous, 1 Reply
Hello All !! I want to tell everyone that I started taking half of the prescribed doses of my meds about 2 years ago. My T cells remain High (570) and my V load is still undetectable..
I am on viramune,ziagen and zerit. I had an uncle who died... Read more »

dosing schedule adjustment

Posted by pozartistsd, 1 Reply
hey all you experts out there! I think i may know the answer to this but would like to get some input:

I currently take my meds (Reyataz/Truvada/Norvir) once a day. I take them at 9am (with breakfast, not that you need to know that ) I would like... Read more »