Taking D4T When You're Hiv Positive

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An Overview of Zerit (Stavudine, d4T)

STAV-yoo-deen Brand Name: Zerit Other Name: d4T Drug Class: Nucleoside Reverse Transcriptase Inhibitors Approved Use: Treatment of HIV Infection WARNING: Stavudine can cause serious, life-threatening side effects. These include lactic acidosis (build up of acid in the blood), liver problems, and pancreatitis (inflammation of the pancreas). Contact your health care provider right away if you have any of the...

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Body Fat and Crixivan/D4T/3TC

I have been on Crix/D4T/3TC for four years and consistently have had undetectable viral loads and over 1200 CD4 cell counts. The challenge I have now is with fat accumulation in the abdominal area. This may seem like a silly question but is it...

Response from Keith Henry, M.D.

University of Minnesota, School of Medicine

Good questions. Exercise and diet and a proper hormonal milieu ( i.e. testosterone levels) might help some but generally not to a satisfactory level. There are some interesting ACTG studies that will be looking at treatment interruptions as an... Read more »

Combivir + Viracept vs. D4T, 3TC, and Fortovase

I am HIV+ for 10+ years, have never had any opportunistic infections, and have never taken any antiretroviral drugs. My viral load hovers between 28,000 and 134,000. Last CD4 was 740. I have two doctors, and one of them would like me to begin...

Response from Kathleen E. Squires, M.D.

University of Southern California's Keck School of Medicine

Dear Confused:If I may make a suggestion it would be that you need to establish a partnership with one doctor. There is no one right way to treat HIV infection; it is very likely that you will continue to receive conflicting advice which may not be... Read more »

Ribavirin and AZT/D4T

Hello Doctor,I heard that Ribavirin cancels out AZT and also D4T. The studies to this topic are all "in vitro". What really happens in case you take a HIV-Combo with AZT or D4T and INF+Riba? In an small study there where no negative...

Response from Douglas T. Dieterich, M.D.

New York University, School of Medicine

There have several small lab studies suggesting that ribavirin might compete for phosphorylation with AZT and D4T. At our site, at Johns Hopkins, in France and Spain, we now have data on over 100 people treated with ribavirin and despite taking AZT... Read more »

D4T and tinnitus?

I have been on treatment for 4 years. Initially I started on d4T, 3tc, nevirapine. A year ago I changed the d4t to tenofivir. After the intial 3 months of treatment (at which time I also started taking an antidepressant, Cipramil) I one day started...

Response from Keith Henry, M.D.

University of Minnesota, School of Medicine

That question/issue has come up in my own practice and I have seen several situations where certain patients seem to have tinnitus due to a particular HIV drug even if it is not reported much or at all in the literature. I do get a good ENT... Read more »

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