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Stories About Protease Inhibitors Working For People

Here's a taste of what has to offer on this topic:
Get the Facts
AIDS InfoNet

Protease Inhibitors in Development

... Protease Inhibitors Protease Inhibitors in Development PIs No Longer in Development NOTE: Several fact sheets describe drugs that are being tested against HIV: Fact Sheet 410 : nucleoside analog reverse transcriptase inhibitors (nukes)
Ask the Experts

will the new drugs work as well in older people as younger?

Im 58 and Ive had HIV longer than anyone I know, at least 23 years. Ive developed resistance to everything Ive taken so far. My doctor wants to me to try some of the new drugs just approved in the last year, selsentry or isentris or something. Is...
Graeme Moyle, M.D.

Response from Graeme Moyle, M.D.

Chelsea and Westminster Hospital
...intelence (a new NNRTI). These drugs may well work for you and will work best if all combined together, typically with a boosted protease inhibitor such as darunavir. Several tests need to be done to determine if each drug is active against your... Read more »

How do protease inhibitors work?

I was wondering how a protease inhibitor acts on the protease of HIV. What does this protease enzyme do that it needs to bestopped?
Cal Cohen, M.D., M.S.

Response from Cal Cohen, M.D., M.S.

Harvard Medical School
...particle from an infected cell. If the proteins necessary for making new virus particles cannot be modified (cleaved) by the protease inhibitor, then the virus particle that gets released from the cell is defective. It cannot infect new cells,... Read more »

Protease Inhibitors Work for Some Not For Others

Why do some protease inhibitors seem to suppress viral loads to nearly 0in some patients and can not in other patients?
Cal Cohen, M.D., M.S.

Response from Cal Cohen, M.D., M.S.

Harvard Medical School
...experienceare: Noncompliance: the drugs are taken erratically, with missed ordelayed doses Lack of effective combination therapy: the protease inhibitors aretaken in combination with drugs to which resistance has alreadydeveloped. Extensive... Read more »

Protease Inhibitors - Do They Work?

My lover has been HIV possitive for the last six years. On his last Doctor's appointment his T-Cell Count was way down. He is the healthiest he has ever been, feels great, but has been under some stress as of the last few months. Could this be the...
Cal Cohen, M.D., M.S.

Response from Cal Cohen, M.D., M.S.

Harvard Medical School
...The reason for the optimism surrounding protease inhibitors is that they work very well, and the more we learn about them, the more enthusiastic we become. Data from the Vancouver conference Read more »
Henry J. Kaiser Family Foundation

Protein Accumulation Might Cause Fat Deposits, Other Side Effects in HIV-Positive People Taking Protease Inhibitors, Study Says

...Similarities between genetic conditions that cause early aging and side effects experienced by some HIV-positive people when taking protease inhibitors might explain the fat accumulation associated with the drugs, according to a study published... Read more »
Henry J. Kaiser Family Foundation

Protease Inhibitor Lowers Viral Loads Among HIV-Positive People With Drug Resistance, Study Finds

...Tibotec's application for sale and marketing of Prezista for use by HIV-positive people who are resistant to first-line drugs. Protease inhibitors work by blocking the action of an enzyme that cuts HIV proteins into the shorter sections that the... Read more »
AIDS InfoNet

Ritonavir (Norvir)

...HIV protease acts like a chemical scissor. It cuts the raw material for HIV into specific pieces needed to build a new virus. Protease inhibitors "gum up" these scissors. Who Should Take It? Ritonavir was approved in 1996 as an antiretroviral... Read more »

GSK Discontinues Clinical Development of Investigational Protease Inhibitor Brecanavir (640385)

...confirms that, due to insurmountable issues regarding formulation, the clinical development program for the investigational HIV protease inhibitor brecanavir has been discontinued. Brecanavir had reached Phase II development. This decision has... Read more »
Connect With Others

Resisting Resistance - A Story

Posted by Survivor, 1 Reply
...research. For the next several years I remarkably maintained my health status while HIV research slowed. I tried other new protease inhibitors as they became available and began "recycling" my medications, reusing past drugs I was most... Read more »

Protease Inhibitors - Hemophilia bleeds

Posted by akcol
...Hemophilic PI increased unusual bleed experiences that we can compile to help all docs understand that PIs can be as dangerous to a person with Hemophilia as the virus we're all trying to control is. He has been taking Reyataz (PI) with Combivir... Read more »

Ageing with AIDS

Posted by ScotCharles, 3 Replies
...years of work that has tracked the incidence of the diseases of ageing in those with HIV. Those studies have found that HIV and Protease Inhibitors both make more likely that a person with HIV will get age related cancers, Alzheimer's, kidney... Read more »

What should I think?

Posted by motherinlaw, 9 Replies
I will try not to make this too son called yesterday and told me his wife was not doing well. My HIV negative son and three HIV negative grandchildren may soon lose their HIV positive wife and mother. My son and daughter-in-law seem not to... Read more »