Smart Trial And Hiv

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Get the Facts

Participating in a Clinical Trial

To Find Out More About Clinical Trials For information about participating in clinical trials or trials availability throughout the U.S., call the AIDSinfo Service at 1-800-448-0440, or visit their Internet web site at http://aidsinfo.nih.gov . The FDA web site has information on the drug development process at www.fda.gov/Drugs/DevelopmentApprovalProcess/HowDrugsareDevelopedandApproved/default.htm .

Ask the Experts

Back on Meds - SMART study.

I am a 44 year old woman who has been infected with HIV since 1989. I started on HAART in 1996 and continued on it until 2002 when I volunteered for the SMART study. I was off medication for almost 3 years until I started having problems with...

Response from Gerald Pierone, M.D.

AIDS Research and Treatment Center of the Treasure Coast

Hello and thanks for posting. Viracept and Combivir used to be one of the best combinations for management of HIV infection, but not anymore. Combivir has been surpassed by Truvada (Viread and Emtriva combo pill) because this newer once daily... Read more »

2nd about t. Strategies (smart)

Thank you for your previous answer. It may be as you say: a good strategy for those people whom are currently in that number of cd4.But one thing I dont understand very well, and allow me to say so, is that aim for not treating people until cd4...

Response from Cal Cohen, M.D., M.S.

Harvard Medical School

No doubt that there are several attractive, compelling arguments in favor of starting meds with a high CD4 count and keeping them there. No doubt that the higher the count, the more likely it is that our immune system can safely do all it is... Read more »

What happened to SMART?

Dear Dr. Pierone,From previous posts, I understand that you are, or rather were, involved in the SMART Study. I recently read that SMART was being discontinued due to poor epidemiological outcomes. Do you concur with this? Or, could this be big...

Response from Gerald Pierone, M.D.

AIDS Research and Treatment Center of the Treasure Coast

Hello and thanks for posting. I am involved in the SMART study and our team has about 70 patients enrolled in the trial. The study is closed to new enrollment but worldwide there are over 5000 patients already in, and the study is ongoing. However,... Read more »

About SMART

I have just read new trial (www.smart-trial.org) on treatment strategies starting in U.S. and Australia. It seems they are going to study patients over 7 years with two treatment strategies: a/treating and maintaining treatment when cd4 fall to...

Response from Cal Cohen, M.D., M.S.

Harvard Medical School

Well, first, thanks for your appreciation. So can we cycle these meds on and off and on again? Will that help? And will the time off be long enough to matter given the counts you note are in the study?There are actually a few different studies... Read more »

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Connect With Others

For Not so smart

Posted by Anonymous, 2 Replies

I didnt see the syringe and i checked fdor awhile and i never saw the needle either but who knows and what kind of n eedles do ppl use to inject drugs ? also it might of been my pants pinching me or my boxers becasusde about 3 days later i sat down... Read more »

Straight, smart, down-to-earth female seeks friend

Posted by eve, 1 Reply

I am looking to correspond with somebody to provide reflection, insight and support to each other. I am a down-to-earth, educated, successful, caring woman who is in a relationship of 6 months with a similar man. (However, he tested positive for... Read more »

To clinical trial or not to clinical trial?

Posted by ai77, 1 Reply

Hello! I hope you're all having a nice weekend. Thanks for helping me get over my mental hurdle last week. You made me realize that just because I've progressed to an AIDS diagnosis doesn't mean I'm on death's doorstep. I really thought being... Read more »

New treatment approach to HIV: trial announcement

Posted by Anonymous

We've applied for patent protection on a novel treatment approach to HIV using existing medications already FDA-approved for other disease indications. We hope our approach will decrease infectivity by HIV virus, as well as delay progression to... Read more »

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