Small Molecule Hiv-1 Inhibitors

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Protease Inhibitors in Development

These drugs have not been approved by the Food and Drug Administration (FDA) for use against HIV. Protease Inhibitors These drugs block the protease enzyme. When new viral particles break off from an infected cell, protease cuts long protein strands into the parts needed to assemble a mature virus. When protease is blocked, the new viral particles cannot mature. Protease Inhibitors in Development Several firms are trying to develop a new...

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integrase inhibitors,where are they?

Dr. Frascino, I know we know of three crucial enzymes necessary for HIV to do its dirty work. Protease, reverse transcriptase and integrase. Why havent we created an integrase inhibitor. And where are we as far fusion inhibitors. Or any type of...

Response from Robert J. Frascino, M.D.

The Robert James Frascino AIDS Foundation

Hello,Where are they? Well, at present, they are "in the pipeline." Exactly how quickly these and other agents will move through the pipeline into broader-based clinical trials, then on to compassionate use/expanded access programs, then... Read more »

When to Jump to New Virus Entry Inhibitors

It appears some of the forthcoming virus entry inhibitors such as the "fusion inhibitors" (T-20 or T-1249) may be available in a year or two. Others, such as a "zinc finger inhibitor" (ADA) may also be on their way. I read in the...

Response from Andrew T. Pavia, M.D.

University of Utah, School of Medicine

Great question, and I am glad you had a chance to hear the talk on viral entry by Robert Doms. It was a phenomenal talk in person, and I am glad it is available on the net. It is a safe bet that HIV will develop escape mutants to almost any approach... Read more »

HIV meds other inhibitors/ smoking

I am currently taking Combivir and Viracept and also am a heavy smoker. I want to quit but I think I might need some help from meds. With the HIV meds that I am currently on is it safe to take other inhibitors such as Zyban or is it safer to use...

Response from Rick Stryker, M.D., M.P.H.

University of California Los Angeles School of Medicine

Quitting tobacco is a great idea, one of the best things you can do to increase your overall well-being. It is not clear, as we once thought, that smoking necessarily increases your risk of HIV progression. But it is still very important to stop,... Read more »

Questions on retroviral enzyme inhibitors in HIV treatment

I wonder if you could tell me some information regarding the absorption and excretion metabolism of saquinavir and zidovudine in HIV/AIDS treatment ?...

Response from Cal Cohen, M.D., M.S.

Harvard Medical School

Not sure what you are asking about here. Both meds are absorbed and then are usually given every 12 hours - since the activated drug appears to last long enough with standard dosing so that you can take either of these just every 12 hours. Now,... Read more »

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lipodystrophy from protease inhibitors

Posted by Anonymous, 4 Replies

I have known about my HIV+ status now for 6 years, and God has blessed me with continued good health. I have accessed all the major medications, plus vitamins to help fight the disease. Once I started taking the new protease inhibitors, I started... Read more »

Integrase Inhibitor

Posted by Survivor

I just wanted people realize there is hope and continued very active DRUG DISCOVERY!

Merck, Gilead Release Strong Findings From Clinical Trials of Experimental Integrase Inhibitor Antiretroviral Drugs

Whitehouse Station, N.J.-based Merck and Foster... Read more »

Protease Inhibitors - Hemophilia bleeds

Posted by akcol

Hi, my fiance is a Long Term NonProgressor - 24 years positive, co-infection HCV, with severe Hemophilia A.

This is a question for the gentlemen with Hemophilia please.
We're requesting any input about any Hemophilic PI increased unusual bleed... Read more »

HIV+ Small Business Owner w/ Insurance Question

Posted by tmd6972, 2 Replies

I'm just curious if there are any other HIV+ small business owners out there that have dealt with insurance issues. We currently have BCBS and I'm covered for medical and presccription BUT it comes at the cost of our insurance for other employees... Read more »

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