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Small Molecule Hiv-1 Inhibitors

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AIDS InfoNet

Protease Inhibitors in Development

...Development Several firms are trying to develop a new type of protease inhibitor that will not be cross-resistant with existing drugs. Another goal is to not require boosting by ritonavir. CTP-518 by GlaxoSmithKline is a new molecule that replaces some hydrogen molecules of atazanavir with deuterium, a related substance. Deuterium is metabolized more slowly than hydrogen. CTP-518 may maintain beneficial blood levels in humans without a...
Ask the Experts


pls what is the meaning of CD4?
Eric Daar, M.D.

Response from Eric Daar, M.D.

UCLA School of Medicine
...surface are referred to as "CD4 cells." The relevance of this molecule and population of cells is that they are the target for HIV infection. In fact, HIV actually uses this molecule to bind to the cell and ultimately get into it to establish... Read more »


Hello Dr. Bob,thanks for you fantastic work. I have four questions for you.What do you think about taking EGCG in the hope of slowing down CD4 cells count decrease?As for serious stuff, what can you tell us about the new drug, maraviroc?It inhibits...
Robert J. Frascino, M.D.

Response from Robert J. Frascino, M.D.

The Robert James Frascino AIDS Foundation, and cancer drugs based on it are now in clinical trials. Researchers have known for some time that EGCG inhibits HIV in lab experiments; the new research suggests how. Scientists from Baylor College of Medicine and the University of... Read more »

integrase inhibitors,where are they?

Dr. Frascino, I know we know of three crucial enzymes necessary for HIV to do its dirty work. Protease, reverse transcriptase and integrase. Why havent we created an integrase inhibitor. And where are we as far fusion inhibitors. Or any type of...
Robert J. Frascino, M.D.

Response from Robert J. Frascino, M.D.

The Robert James Frascino AIDS Foundation
...presented at a future conference in 2006. The development of these agents are important when we consider that at late stages of HIV infection, CXCR4 viral phenotypes have been linked with rapid progression to AIDS. It is postulated that a CXCR4... Read more »

new development in the drug Maraviroc

Dear Dr.Bob,Hope you are well.I was just watching the news in England when a story about the HIV drug called Maraviroc was discussed. It was said that in a few months the drug will be available on the NHS (national health service in England). As you...
Robert J. Frascino, M.D.

Response from Robert J. Frascino, M.D.

The Robert James Frascino AIDS Foundation
...reported similar findings, and also observed that individuals heterozygous for the mutation experienced partial protection against HIV infection.Individuals homozygous for the mutant allele are not entirely protected from HIV infection, since... Read more »
U.S. Centers for Disease Control and Prevention

"Smart Bomb" RNA Molecule Could Take Out Drug-Resistant HIV

...the gp120 protein found on the surface of HIV's envelope and on HIV-infected cells. It is designed to neutralize free-floating HIV in the blood and attach to and deliver into infected cells a small interfering RNA (siRNA) "that triggers... Read more »
Henry J. Kaiser Family Foundation

Sugar Molecule Can Protect Against HIV, Study Finds

... A sugar molecule called the Pk blood group antigen might provide a defense against HIV, according to a study published last week in the journal Read more »
U.S. Centers for Disease Control and Prevention

Molecule on Immune Cells Linked to Sexual Transmission of HIV step will be to investigate if this is true." "We believe our findings point to a new therapeutic target for preventing HIV infection," said Dr. Peter Anton, UCLA professor of medicine. "Drugs could be developed to block the interaction... Read more »
AIDS Treatment News

Antiretroviral Pipeline: New-Drug Reports from Retroviruses Conference

...needed to block HIV replication. Shortly before the conference the company received "proof of principle" that the drug can reduce HIV in people: data showing that the compound did lower viral load and appeared to be safe, in an 8-day trial in 30... Read more »
Connect With Others

does this mean you have hiv when u have this hla

Posted by need2know01, 1 Reply
... In protection against HIV or SIV virus (1, 2, 3), CD8 CTL play a major role. Nevertheless, the natural immune response to HIV is often unable to clear the infection. Although a number of Ags that induce CTL responses and can help to eliminate... Read more »

Green tea?

Posted by franfrog
... Green Tea Blocks HIV in Test Tubes Too Soon to Know if Green Tea Will Do the Same in People By Miranda Hitti WebMD Medical News Reviewed By Ann Read more »

To John In London

Posted by une_fille, 1 Reply
hi there. i've never even heard of a bdna. i've had a dna at i think it was 7 weeks past exposure and i've had a negative 3 month elisa (3rd generation). i'm concerned what you said about the bdna, that it picks up strains found in europe and not... Read more »

HIV-1 and HIV-2 ?

Posted by codymartinnc, 1 Reply
...Greatly appreciate if someone can provide details on specifics of the result. Below is the result: Tests performed by Lab Corp HIV 1/O/2 Abs, Qual Non Reactive Does that mean that tests antibody tests were done for both HIV-1 and HIV-2 ? Can... Read more »