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Side Effects Of Fusion Inhibitors

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AIDS InfoNet

Fusion and Attachment Inhibitors

Note: Several fact sheets describe drugs that are being tested against HIV: Fact Sheet 410 : nucleoside analog reverse transcriptase inhibitors (nukes) Fact Sheet 430 : non-nucleoside analog reverse transcriptase inhibitors (NNRTIs or non-nukes) Fact Sheet 440 : protease inhibitors Fact Sheet 470 : other antiretroviral drugs in development Fact Sheet 480 : immune therapies These drugs have not been approved by the Food and Drug...
Ask the Experts

Fusion Inhibitors

Can you shed any light on what, if any, of the preliminary reports on fusion inhibitors may include as far as side effects? I guess I am assuming they have done some human trials??...
Keith Henry, M.D.

Response from Keith Henry, M.D.

University of Minnesota, School of Medicine
T-20 = Fuzeon is the only fusion inhibitor soon to be more widely available. Since it acts outside of cells (blocking fusion) its toxicity would be expected to be low and that has been the case in major clinical trials conducted to date. The major... Read more »

Fusion inhibitors

I would very much like to know if fusion inhibitors are going to produce loss or fat acumulations like protease inh., and if the new Tenofovir has more of these kind of side effects than other transcriptase inhibitors. Thank you...
Keith Henry, M.D.

Response from Keith Henry, M.D.

University of Minnesota, School of Medicine
T-20 (the only fusion inhibitor in wide use) has not been associated with lipodystrophy yet. Since it works extracellularly there is hope that some of those problems associated with unwanted activity of a drug inside cells might be avoided. It... Read more »

Fusion inhibitors and clinical trials.

I have recently reached the point where I need to start taking anti-HIV medications and I am seeking your advice on how to proceed.Our local AIDS Clinical Trials Unit needs people who are treatment-naive for a study involving fusion inhibitors in...
Gerald Pierone, M.D.

Response from Gerald Pierone, M.D.

AIDS Research and Treatment Center of the Treasure Coast
I think that your primary ID doctor is correct. A simple regimen would probably work as well with fewer side effects. Fusion inhibitors require daily injections and are no walk in the park. If you do decide to participate in this trial you should... Read more »

Fusion and entry inhibitors

Dr. Young: Hi. When several of the fusion and entry inhibitors become a reality for HIV treatment will these agents be taken combination as HAART is today? And will these treatments have a lower toxcidy and resistant profiles than HAART or is it...
Benjamin Young, M.D., Ph.D.

Response from Benjamin Young, M.D., Ph.D.

Rocky Mountain CARES
Thanks for your question.Fusion (or entry) inhibitors should make their debut in the near future with the release of enfuvitide (nice name, huh--otherwise known as Fuzeon or T-20). The class of medications is exciting from the perspective that many... Read more »
Connect With Others

Fusion Inhibitor News?

Posted by Anonymous
Does anyone know if the fusion inhibitor trials (phase III) are going OK, or where to go for an update? Last I heard 700 patients in 100 countries were in the study for T-20(?)
I went to the Trimeris site and didn't see anything new.

Read more »

New Drug Fuzeon

Posted by Anonymous, 1 Reply
There's a lot of talk about "Fuzeon", a breakthrough fusion inhibitor. It has passed the clinical trial stage and is now in commercial production stage. Lately there has been talk about Roche/Trimeris not being able to make the numbers, due to a... Read more »

Life expectancy, cont.

Posted by Anonymous, 1 Reply
Do yall agree that HIV is becoming more and more a treatable disease like diabetes, where the majority of people who come down with the virus, while never being cured, will be able to be treated to where the virus is contained and never develops... Read more »

new to group

Posted by Jackie_Y, 1 Reply
hi, i'm new to the group and would like to talk about aids. i dont know alot about it and would like to talk with someone. my birth father has aids. we was talking today and he was tell me about a drug called T-20. i'm not sure what that is and... Read more »