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Side Effects Of NNRTIs

Here's a taste of what has to offer on this topic:
San Francisco AIDS Foundation

Drug Watch: Next-Generation NNRTIs: Etravirine and Rilpivirine

Why Do We Need More NNRTIs? Leading the Next Generation: Etravirine and Rilpivirine Etravirine: The DUET Studies Rilpivirine Implications for Treatment Selected Sources Even in patients with the most resistant virus, our goal now is full... Read more »
Seattle Treatment Education Project

Know Your HIV Drugs: NNRTIs

Non-Nucleoside Reverse Transcriptase Inhibitors (NNRTIs) NNRTIs are another class of FDA-approved HIV antiviral drugs. There are currently three drugs approved for use in this class. NNRTIs work by targeting the structure of reverse transcriptase... Read more »

NNRTIs: The Next Generation Approaches

Case Study: Patient JD JD is a 46-year-old gay male. He first learned of his HIV status in 1994 after a former partner with whom he had been in a three-year relationship discovered that he was HIV infected. JD felt well when he was first tested for... Read more »
Ask the Experts

Sustiva causing resistance to other nNRTIs

Sustiva (efavirenz)-Induced Mutation in Subtype C HIV May Confer Multi-NNRTI ResistanceA mutation at codon 106 in HIV-1 clade C viruses that occurs after exposure to efavirenz appears to result in high-level resistance to other non-nucleotide...
Benjamin Young, M.D., Ph.D.

Response from Benjamin Young, M.D., Ph.D.

Rocky Mountain CARES
Thanks for pointing out the research.So far, this does not seem like a very common issue-- however, a different mutation at codon 103 is commonly found among persons with clade B HIV (the US, Western Europe flavor)- this mutation usually causes high... Read more »


Are either of the newer NNRTIs, Edurant or Intelence processed differently by the liver than the older drug Viramune? I have been on Viramune for more than 10 years just wondering of switching to one of the newer ones would be considered more...
Keith Henry, M.D.

Response from Keith Henry, M.D.

University of Minnesota, School of Medicine
The major liver concern with nevirapine is early on treatment. After 10 years the rate of liver problems on nevirapine would be expected to be low. Though etravirine and rilpivirine may be viewed as being more liver friendly there is minimal very... Read more »

NNRTIs and lipitor

What is your feeling about Lipitor to lower cholesterol in patients on nnrti regimens? I've been on Sustiva/Truvada for 14 weeks with great results but have been battling high cholesterol for about 10 years, HDL high, LDL low, well controlled...
Mark Holodniy, M.D., F.A.C.P., C.I.C.

Response from Mark Holodniy, M.D., F.A.C.P., C.I.C.

Stanford University, School of Medicine
Lipitor and other statins are not on the absolutely contraindicated list on the FDA approved package insert for sustiva. With anything you just need to be careful and have close followup.... Read more »

GI side effects

Which HIV treatment for initial therapy, on the preferred list, has the most gastrointestinal side effects?...
Brian Conway, M.D.

Response from Brian Conway, M.D.

University of British Columbia
This is an interesting question. Unfortunately, they will all have side effects of this type, to a greater or lesser extene.Among the nucleosides, I would watch more carefully for these types of things to occur with didanosine and zidovudine. They... Read more »
Connect With Others

Entry Inhibitors

Posted by Anonymous, 1 Reply
Does anyone know anything about the new entry inhibitors? I think Pfizer and Schering both have drugs in development. Should we be hopeful? Read more »

Lab, med change, confusion

Posted by kaplan08, 2 Replies
Labs of last year have shown a vload range between <400 and 793, with <400 being most recent; CD4 percentage range from 31% to 34%, with 33% being most recent. Taking only Viramune and Combivir -a test has recently shown resistance to... Read more »

One Year Ago

Posted by Blixer, 7 Replies
One year ago tonight (actually 52 weeks to the day) I made my first post in the "I Just Tested Positive" forum. I was a basket case. I had just been diagnosed hours before. I came here for help and I found it. I've grown a lot since then and I'm... Read more »

Re: Something uplifting

Posted by SA_Intellect, 3 Replies
The link below is the response one of the doctors on The Body posted to my question. Read it. It's very positive and will hopefully add a bit of peace to some your hearts. Read more »