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Should I Take Enfuvirtide If I Have Aids

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Get the Facts
AIDSinfo

An Overview of Fuzeon (Enfuvirtide, T-20)

... en-FYOO-vir-tide --> Brand Name: Fuzeon Other Name(s): DP 178, DP178, Enfuvirtida, Pentafuside, T 20, T-20, T20 Drug Class: Entry and Fusion Inhibitors Enfuvirtide, also known as Fuzeon or T-20, is a type of medicine called a fusion inhibitor. Fusion inhibitors work by blocking HIV from entering human cells. HIV/AIDS-Related
Ask the Experts

t-20 work against hiv 2?

Dr. Gerald,Does t-20 work against hiv 2?Ray
Gerald Pierone, M.D.

Response from Gerald Pierone, M.D.

AIDS Research and Treatment Center of the Treasure Coast
...It should work against HIV-2. There is very little in treatment literature about HIV-2 except that protease inhibitors work. Read more »

T20 and HIV-2

Dear Dr Pierone,At our hospital we have quite some experience with HIV-2 treatment. I stumbled onto your answer to the question whether T20 works against HIV-2 (posted in november 2003). T20 does not work against HIV-2 however. T1249 (which is not...
Gerald Pierone, M.D.

Response from Gerald Pierone, M.D.

AIDS Research and Treatment Center of the Treasure Coast
...Thanks for the information about T20 (Fuzeon) and your observations on lack of impact on HIV-2. More studies need to be done and published to help clinicians with HIV-2 treatment issues. Thanks again. Read more »

t-20 against hiv-2?

Dr. Pierone,Do entry inhibitors work against hiv type 2 infection, if so does t-20 work? thanks.Louis
Gerald Pierone, M.D.

Response from Gerald Pierone, M.D.

AIDS Research and Treatment Center of the Treasure Coast
...There is no reason to suspect that entry inhibitors (including T-20) would not work against HIV-2 although I don't know if they have been studied yet. Read more »

Injection of T-20 (Enfuvirtide)

Hello, I'm a physician treating a patient with T-20. The injections have been causing him reactions at the site - namely erythema, nodules, pruritus, ecchymosis, pain and discomfort. What techniques do you use or recommend to lessen these ISR's? ...
Keith Henry, M.D.

Response from Keith Henry, M.D.

University of Minnesota, School of Medicine
...the inject site with ice packs for some while for others heat/message has helped. Since there likely will be a number of new HIV drugs active against resistant virus available over the next 6-12 months (such as integrase inhibitors and CCR5... Read more »
Articles
AIDS Treatment News

T-20: Most Expensive AIDS Drug Ever at $25,000 Per Year?

...medical care. Will we be moving toward separate treatment guidelines for those who can and cannot pay? ISSN # 1052-4207 Copyright 2003 by John S. James. Permission granted for noncommercial reproduction, provided that our address and phone... Read more »
U.S. Centers for Disease Control and Prevention

Long-Term Treatment With Subcutaneous T-20, a Fusion Inhibitor, in HIV-Infected Patients: Patient Satisfaction and Impact on Activities of Daily Living

...develop virologic failure through incomplete viral suppression and the emergence of drug-resistant strains. The synthetic peptide T-20 is a novel antiretroviral agent that inhibits the fusion of HIV with target cell membranes. HIV-infected adults... Read more »
Canadian AIDS Treatment Information Exchange

T-20: Will Long-term Use Weaken the Immune Systems Ability to Fight HIV?

...National Institutes of Health (NIH) in Bethesda, Maryland, have found that in laboratory experiments the experimental anti-HIV drug T-20 suppresses the production of IL-12 by an important group of immune cells called monocytes. Perhaps these... Read more »
Seattle Treatment Education Project

Fuzeon (T-20), the First HIV Entry Inhibitor, Is Now FDA-Approved

...showing that the next entry inhibitor in development at Roche, T-1249, has some efficacy in people who developed resistance to T-20. So, a major question is whether to add Fuzeon now or wait until another new drug becomes available to add with... Read more »
Connect With Others

Thanks for your support and any more advice?

Posted by motherinlaw, 3 Replies
I want to thank everyone for their support and help. I posted this in response to my own previous posting and felt it might have gotten lost in the shuffle and so am reposting. I have just spoken to my son again. He was finally able to convince... Read more »

info

Posted by Anonymous, 1 Reply
...transcriptase inhibitors (NNRTIs), and protease inhibitors (PIs). However, the mans virus was susceptible to the fusion inhibitor T-20 (enfuvirtide, Fuzeon) and the NNRTI efavirenz (Sustiva). According to an update issued March 29 th by the New... Read more »

What should I think?

Posted by motherinlaw, 9 Replies
...I will try not to make this too long...my son called yesterday and told me his wife was not doing well. My HIV negative son and three HIV negative grandchildren may soon lose their HIV positive wife and mother. My son and daughter-in-law Read more »

information

Posted by Anonymous, 1 Reply
...Fosamprenavir (Lexiva) FDA also has introduced a third new class of drugs, known at fusion inhibitors, to treat HIV infection. Fuzeon (enfuvirtide or T-20), the first approved fusion inhibitor, works by interfering with HIV-1's ability to enter... Read more »