Should I Take Delavirdine

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Get the Facts

Delavirdine (Rescriptor)

What Is Delavirdine? Delavirdine is a drug used as part of antiretroviral therapy (ART). It is also called Rescriptor. Pharmacia & Upjohn developed it. ViiV Healthcare is marketing it. Delavirdine is a non-nucleoside reverse transcriptase inhibitor (a "non-nuke" or NNRTI). These drugs stop HIV from multiplying by preventing the reverse transcriptase enzyme from working. This enzyme changes HIV's genetic material (RNA) into DNA. This has to...

Ask the Experts

Agenerase Dose w/ Delavirdine & Abacavir

Dear Dr. Cohen,Having been on nearly every drug available for the past 11 of my 42 years, my most recent geno and phenotypes show that my least resistance is to the drug combo of delavirdine/agenerase/abacavir. I had been on AMP/ABV/EFV since my...

Response from Cal Cohen, M.D., M.S.

Harvard Medical School

Well, Paul, Congrats on first doing your homework. Here are a few thoughts to add.First - the tenofovir expanded access recently expanded - now anyone with any CD4/viral load may be eligible - so this is again an option. Whether you should play... Read more »

Worried about delavirdine

I recently started therapy for the first time after being diagnosed with HIV 2 years ago. My doctor prescribed Combivir and abacavir 2 weeks ago. I have been taking this combination with no real problems. Just yesterday, my doctor prescribed...

Response from Cal Cohen, M.D., M.S.

Harvard Medical School

Well it is unclear what motivated the decision to pick delavirdine in preference to the others. You do hear more about the others since the data we have have led us to be more confident in them. However at least one study a few years ago with... Read more »

Delavirdine interactions with Indinavir and other antiretrovirals.

Hi Dr. Cohen!Bob Frascino spoke to a group of us in Monterey, CA last week and began for the first time to explain why I have remained undetectable for so long(4+ years) on the same five drug regimen even though my dosing schedule was not precise....

Response from Cal Cohen, M.D., M.S.

Harvard Medical School

Yup. Very clear. Hope the answer is equally lucid.Yes -- delavirdine (for simplicity I'll abbreviate it DLV) does have similar effects on the p450 system as does ritonavir. Not as potent but similar. So yes you can dose reduce the IDV to... Read more »

Is NNRTI class a MUST?

Is it possible to have combinations of only NRTI + PI instead of NRTI + NNRTI + PI?I could not tolerate all the NNRTI pills, Rescriptor/delavirdine, Sustiva/efavirenz and Viramune/nevirapine.Thanks....

Response from David Wohl, M.D.

University of North Carolina - Chapel Hill

Absolutely. There are no data showing any advantage of a regimen of all three classes versus the standard 2 NRTIs+PI or 2 NRTIs+NNTRI.Triple class therapy only offers more toxicity.See the current US Department of Public Health Guidelines at... Read more »

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Rescriptor (delavirdine mesylate)

Posted by Anonymous

Is anyone taking this drug? Are you experiencing any side affects. I've only been taking it for a week and now I have a cold/allgery problem (watery eyes and nose). I don't know if it the medicine or just a normal cold/allgery.

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What should I think?

Posted by motherinlaw, 9 Replies

I will try not to make this too long...my son called yesterday and told me his wife was not doing well. My HIV negative son and three HIV negative grandchildren may soon lose their HIV positive wife and mother.
My son and daughter-in-law seem not to... Read more »

Resisting Resistance - A Story

Posted by Survivor, 1 Reply

Personal Perspective: Resisting Resistance

By Matt Sharp

Spring 2006

In a little over four months I will turn fifty. When I was diagnosed with HIV in 1988 I never dreamed I'd reach forty. I've survived a long battle with HIV, and it has not been... Read more »

Thanks for your support and any more advice?

Posted by motherinlaw, 3 Replies

I want to thank everyone for their support and help. I posted this in response to my own previous posting and felt it might have gotten lost in the shuffle and so am reposting.

I have just spoken to my son again. He was finally able to convince his... Read more »

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