Rna Polymerase In Hiv

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Articles

Oral Antivirals: HCV Protease and Polymerase Inhibitors

The NS3-4A serine protease enzyme and the NS5B RNA-dependent RNA polymerase enzyme are primary targets for oral antiviral agents, since both enzymes are essential for HCV replication. Unfortunately, HCV's high replication rate -- billions of copies... Read more »

FDA Review of Viral RNA Testing

Shortly after the approval of the three protease inhibitors, the FDA reviewed the diagnostic assays that quantitate HIV RNA.These tests are being used by many clinicians to monitor viral loads in their patients and to assess their response to... Read more »

U.S. Centers for Disease Control and Prevention

"Smart Bomb" RNA Molecule Could Take Out Drug-Resistant HIV

Researchers have engineered an RNA molecule to block freely circulating HIV as well as replication inside infected cells. Tests in mice engineered to be susceptible to HIV showed the chimeric RNAs reduced HIV-1 replication by several orders and... Read more »

Ask the Experts

Using Polymerase to Combat Infection?

I have been told that there aren't many t-4 receptors in the human body. If the genetic code for ~only~ the t-4 receptor could be isolated, couldn't PCR replicate the receptor? What I'm wondering is this -- couldn't infected...

Response from Rick Stryker, M.D., M.P.H.

University of California Los Angeles School of Medicine

Interesting thought, that perhaps one could "mimic" the process of HIV binding to T-4 (AKA CD4+ or helper cells)and trick the virus into releasing its deadly package of instructions (RNA) harmlessly into some non-infectious state.... Read more »

APTIMA HIV-1 RNA QUALITATIVE ASSAY (APTIMA - HIV-1 RNA QUALITATIVE ASSAY, 2010) Part 2

To the good Dr. Bob, I have submitted a donation on-line, and will submit a heftier holiday donation as well, but in the interim I was hoping you might field another inquiry from me regarding a post of mine a few weeks ago pertaining to the Aptima...

Response from Robert J. Frascino, M.D.

The Robert James Frascino AIDS Foundation

Hi Aptimistaken,You're going to qualify for an advanced degree in nucleic acid polymerase chain reaction laboratory analysis before long. Dude, it's time to turn off your inner scientific geek and come back to planet earth. I can't... Read more »

HIV RNA Test/HIV DNA PCR Test

Dr Brook, to one of your answers dated 28 October 2001, DNA PCR Test while Pregnant you said that the HIV RNA test is more sensitive than the HIV DNA PCR test for detecting early infection if you are not taking antiretrovirals. Now does this mean...

Response from Brooks Jackson, M.D.

Johns Hopkins University, School of Medicine

Once an adult individual is infected with HIV and is antibody positive, the use of antiretrovirals for treatment will not cause the ELISA test for HIV antibody to become negative. BJ... Read more »

Accuracy pf HIV1 RNA PCR

Hello DocWhat is the acuuracy of an RNA PCR after one month of possible exposure?...

Response from Mark Holodniy, M.D., F.A.C.P., C.I.C.

Stanford University, School of Medicine

Accuracy is 100% if HIV infection is present.... Read more »

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Connect With Others

Difference between RNA-PCR and RNA-bDNA tests?

Posted by Anonymous, 1 Reply

Does anybody know the difference between RNA-PCR and RNA-bDNA tests?

Are these tests accurate? Any false negative or false positive results? Are they worth taking to evaluate early HIV infection when possible early HIV infection symptoms are present?

I... Read more »

< 400 copies of HIV RNA per 1 ml of plasma (????)

Posted by Anonymous

PCR RNA @ 28 Days...

Is this a woo-hoo ?
Read more »

Undetected HIV-1 RNA,PCR at 17 weeks

Posted by roma2010, 2 Replies

hiya all i have the results of my 17 close to 18 weeks results of a PCR RNA for HIV-1 and it was undetected testing was done by COBAS AmpliPrep (Roche Molecular systems) qualification range of this assay is 48 to 10,000.000 copies i also went to a... Read more »

PCR DNA or RNA

Posted by Anonymous, 1 Reply

Quantitative PCR RNA is the viral load test for HIV-1 only, right ?
For Qualitative PCR DNA for HIV-1 and HIV-2, the report format would be 'detectable' or 'not detectable', right ?..or/and would 'strain' of the hiv founded would be reported ?
To... Read more »

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