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Risks Of Tipranavir

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Get the Facts

An Overview of Aptivus (Tipranavir)

tip-RAN-na-veer --> Brand Name: Aptivus Other Name(s): TPV Drug Class: Protease Inhibitors Tipranavir, also known as TPV or Aptivus, is a type of medicine called a protease inhibitor (PI). PIs work by blocking protease, a protein that HIV needs to make more copies of itself. HIV/AIDS-Related Uses Tipranavir, to be coadministered with ritonavir, was approved by the FDA on June 22, 2005, for use with other antiretroviral...
Ask the Experts

should I be worried about aptivus?

Hi,I just read on this site about a "black box" warning that Aptivus can cause "intracranial hemmorrage". What does this mean, and is this something I should be worried about?Thanks -- JD
Benjamin Young, M.D., Ph.D.

Response from Benjamin Young, M.D., Ph.D.

Rocky Mountain CARES
The "black box" means that the FDA has issued a significant need-to-know about drug safety.In the case of tipranavir (Aptivus), a small, but significant number of patients developed intracranial hemmorrhage (ICH, bleeding in the brain) while... Read more »

Darunavir Cross Resistance

35yo male, healthy, HIV positive (VL stable over the last years @ 25k, CD4 has always been between 720 and 780). My long-term partner is negative, and I finally decided to start treatment to decrease transmission risk. Phenotype and genotype test...
Renslow Sherer, M.D.

Response from Renslow Sherer, M.D.

University of Chicago Hospitals
A darunavir-based regimen with ritonavir boosting is among the preferred regimens in the current DHHS Guidelines for the Use of Antiretroviral Therapy, so the experts agree with you that this is a good option. Darunavir was added to the 'preferred'... Read more »

Kaletra is somewhat still effective. Should I change?

My viral load bounces between 50 to 380. Genotype testing suggest virus is somewhat sensitive but not fully sensitive to Kaleta. Dr. suggested darunivar but I am allergic to sulfa based meds. I will be adding Issentress and Truvada. Should I explore...
Joseph McGowan, M.D., F.A.C.P.

Response from Joseph McGowan, M.D., F.A.C.P.

North Shore University Hospital
Dear Dennis,I am assuming that your adherence with the medications is not an issue and that you are not missing doses.The goal is to have 3 fully active drugs in the regimen. This can be achieved through adding up partly active drugs or just having... Read more »

Presista and Sulfa

My doctor recently gave me my new combo (I have t cells of 10). It is MK-518, TMC 114 and 125, Prezista with Norivir boost and Truvada. I am worried because I have n allergy to Sulfa. I got a 105 fever and terrible skin rash/hives and a 104.8...
Benjamin Young, M.D., Ph.D.

Response from Benjamin Young, M.D., Ph.D.

Rocky Mountain CARES
Thanks for your post.The sulfur atom in darunavir (Prezista) and sulfamethoxazole (Bactrim) are not similar in general chemical composition. In general, there isn't an excess risk of sulfur-based allergy to Prezista in those who are allergic to... Read more »
AIDS InfoNet

Tipranavir (Aptivus)

What Is Tipranavir? Who Should Take It? What About Drug Resistance? How Is It Taken? What Are the Side Effects? How Does It React With Other Drugs? What Is Tipranavir? Tipranavir is a drug used as part of antiretroviral therapy... Read more »
Test Positive Aware Network


Common Name: tipranavir (TPV) Brand Name: Aptivus Class: HIV protease inhibitor (PI) Standard dose: Two 250 mg capsules with two 100 mg capsules of Norvir, both twice daily. Must be taken with Norvir. Oral solution available;... Read more »
AIDS InfoNet


What Is Diarrhea? Is Diarrhea Dangerous? What Causes Diarrhea? How Do I Know What Is Causing My Diarrhea? How Is Diarrhea Treated? The Bottom Line What Is Diarrhea? Diarrhea is an increase in the water content, frequency, and... Read more »
The Well Project

HIV Drug Chart/Overview

Table of Contents Introduction Nucleoside and Nucleotide Reverse Transcriptase Inhibitors (NRTIs) Non-Nucleoside Reverse Transcriptase Inhibitors (NNRTIs) Integrase Inhibitors Protease Inhibitors... Read more »
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Okay from the Top I am A gay male but have never really been interested in a dating or regular partner.In the past Ive been hooking up on net or rest stops but just giving oral nothing else .I admit I always enjoyed swallowing semen a lot and Over... Read more »

What foolish and senseless behavior. Please Help!

Posted by brainshom, 1 Reply
About 2 months ago, I did something that was completely out of my character and now I am scared as hell. I was new in the neighborhood and had a one night stand with a girl whom I later found out was/is a prostitute. Had I known she was a sex... Read more »

I'm major stressed is this low risk/no risk?

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Just over two weeks ago i finally gave in to my bi-curious urges and met up with a complete stranger who i got chatting to online. His profile said he had a bfd he said he was single, and also let slip that he'd been assaulted on the scene a few... Read more »