Risks Of Trizivir

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Get the Facts

Trizivir (Zidovudine + Lamivudine + Abacavir)

What Is Trizivir? Trizivir is a pill that contains three antiretroviral drugs (ARVs) used to fight HIV: zidovudine (Retrovir, AZT), lamivudine (Epivir, 3TC) and abacavir (Ziagen). Trizivir is manufactured by ViiV Healthcare. Generic versions have been tentatively approved under PEPFAR (see Fact Sheet 475 ). The drugs in Trizivir are called nucleoside analog reverse transcriptase inhibitors, or nukes. These drugs block the reverse transcriptase...

Ask the Experts

trizivir or trizivir plus viramune

Last month, blood tests show a blip 50 instead of less than 40 on trizivir alone after being undetectable for 2 years. My doctor recommended adding viramune to preclude possible resistance with trizir alone. Please advise!...

Response from Renslow Sherer, M.D.

University of Chicago Hospitals

The use of trizivir alone has recently been shown to be less successful at controlling viral replication than three drug regimens containing efavirenz after 48 weeks. For this reason, many physicians are following patients on trizivir alone more... Read more »

Trizivir, Viread & lipodystrophy

Poz 14+ yrs. Started on combivir 7 yrs ago and graduated to trizivir. 2 out of 3 of my last blood lab tests showed a 'blip' in viral load from undetectable to detectable (however minimal at 100, t's are at 1200 and have never been...

Response from Graeme Moyle, M.D.

Chelsea and Westminster Hospital

There have not been and prospective studies of the risk of lipo with Trizivir but we do know it can occur in people who have only ever received AZT based regimens.If your CD4 has never been below 750 arguable you could stop treatment...that would... Read more »

Could I only take Trizivir?

I have been taking Norvir,Fortovase,Ziagen and Zerit for two years, Ibeen undetectable since I started this treatment but now I feel is time to change to something not that strong.My cd4 are in 1020 and lees than 50 copies of the virus in my blood....

Response from Brian Boyle, M.D., J.D.

Cornell University, Weill Medical College

Several studies have clearly shown that patients who have previously been treated with AZT are at signifcantly higher risk of failing a Trizivir regimen. Therefore, I would be reluctant to switch you to Trizivir. If you want to simplify your... Read more »

trizivir solo and undetectable.why change?

dear dr. i have been hiv pos for 5 years. have had undetectable viral load and 500 t-cells since beginning treatment with combivir and crixivan four years ago. 1 year and half ago I switched to trizivir to get away from protease inhibitors.i have...

Response from Brian Boyle, M.D., J.D.

Cornell University, Weill Medical College

The data from the newly released ACTG 5095 trial indicate that Trizivir therapy is significantly inferior to treatment with an Sustiva/Stocrin (efavirenz) containing regimen. The failure rate was signficantly higher in the Trizivir arm, and... Read more »

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Trizivir

Posted by slitter028, 1 Reply

I have taken Trizivir ever since it came out. The standard dosing is 1 tab bid. My doc has told me on several occasions that i can take both pills at once if it was more convienent for me, because i take viread also, which is once a day, which would... Read more »

Trizivir??????

Posted by Anonymous

I am currently taking epivir, zerit and viracept, but am thinking of switching to Trizivir (epivir,retrovir and ziagen in one tablet). Does anyone have any experience with Trizivir? What kind of side effects? Does it contribute to lypodistrophy less... Read more »

Trizivir resistance

Posted by Anonymous

I was diagnosed in Nov. 2000 and started Trizivir immediatly bc of high VL and low CD4. Immediatly there were reluts and eventually became undetectable and stayed that way for over a year. Now my VL has been increasing but no CD4 decrease. Is... Read more »

trizivir

Posted by Anonymous, 4 Replies

Does anyone else who takes Trizivir have really severe stomach pain?
Also, I am batteling with Lymphoma. Read more »

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