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Reverse Transcriptase Of Hiv

Here's a taste of what has to offer on this topic:
Get the Facts
AIDS InfoNet

Non-Nucleoside Reverse Transcriptase Inhibitors in Development

... Non-Nucleoside Reverse Transcriptase Inhibitors NNRTIs in Development NNRTIs No Longer in Development Note: Several fact sheets describe drugs that are being tested against HIV: Fact Sheet 410 : nucleoside analog reverse transcriptase inhibitors (nukes)
Ask the Experts

haart therapy and hiv genes

Of the nine HIV genes, which one according to HAART therapy would be the most dangerous if it were to mutate?
Mark Holodniy, M.D., F.A.C.P., C.I.C.

Response from Mark Holodniy, M.D., F.A.C.P., C.I.C.

Stanford University, School of Medicine
...Almost all HIV drugs work on HIV enzymes (reverse transcriptase and protease) that are co-located in the HIV-1 pol gene. Mutations in the gene sequences coding for these enzymes are known to Read more »


Can you please explain to me what genotyping is??And how it's done? And are there different strains of HIV, and if so, how many? ps-very confused
Benjamin Young, M.D., Ph.D.

Response from Benjamin Young, M.D., Ph.D.

Rocky Mountain CARES
...the HIV chromosome. Typically the genes encoding the targets of HIV treatments are the ones that are examined-- namely HIV reverse transcriptase and protease.There are indeed many different "strains" of HIV-- fortunately, they share highly... Read more »

Stocrin and Babies (Safety and Toxicity of Anti-HIV Medications During Pregnancy, 2009)

Hi,Thanks for all the advise so far.I am 34yr female and positive for the last 11yrs, am considerng having a baby next year.I have been on stocrin and truvada for the last two yrs.I know stocrin is not compatable with pregnancy so I need advice as...
Robert J. Frascino, M.D.

Response from Robert J. Frascino, M.D.

The Robert James Frascino AIDS Foundation a cell's powerhouse) that can cause problems in the heart, nerves, muscles, pancreas, kidneys, and liver. Non-nucleoside reverse transcriptase inhibitor (NNRTI): class of anti-HIV medication. NNRTIs work by blocking reverse transcriptase, a... Read more »

Reverse transcriptase inhibitors effect on telomeres

I recently started on Atripla and was trying to understand how it works and potential long term effects. So as I understand it (and I'm not a microbiologist by any stretch) the main purpose of the Sustiva in Atripla is to inhibit the reverse...
Keith Henry, M.D.

Response from Keith Henry, M.D.

University of Minnesota, School of Medicine
...I am not aware of any data that has shown that nucleoside reverse transcriptase inhibitors (that are HIV DNA chain terminators not directly involving human DNA) clinically impact human chromosome or telomore Read more »
The Body PRO

Abstract No. 116: Mutations in the Reverse Transcriptase Genome of HIV I Isolates Derived from Subjects Treated with Didanosine and Stavudine in Combination

...with DDI and d4T in combination. Finally, the authors summarize that the data highlights the complex relationship between HIV I phenotypic and phenotypic resistance and HIV viral loads in individuals treated with dual nucleoside combinations.... Read more »
The Body PRO

Clinical Trials of HIV-1 Reverse Transcriptase Inhibitors (Session 40) Clinical Trials of HIV-1 Protease Inhibitors (Session 41) Immune Reconstitution (Session 45) Treatment of Primary Infection (Session 47)

... Clinical Trials of HIV-1 Reverse Transcriptase Inhibitors (Session 40) START Observational Study: Longitudinal Follow-Up of Virologic and Immunologic Responses in START I Read more »
The Body PRO

Clinical Trials of HIV-1 Reverse Transcriptase Inhibitors

...200mg BID NVP) to a protease-inhibitor-containing regimen (nelfinavir 750mg TID NFV) each given with the background nucleoside reverse transcriptase inhibitor Combivir (ZDV 300mg/3TC 150mg BID). The study enrolled 142 HIV-infected patients... Read more »
The Body PRO

Session 84, Abstract 664: Therapy with d4T plus 3TC Produces Sustained Undetectable Levels of Plasma HIV RNA in Patients Treated with Reverse Transcriptase (RT) Inhibitors for 10 Years

...interesting conclusions worthy of further study. The researchers indeed found that certain patients who have received long-term reverse transcriptase inhibitor therapy may still benefit from relatively simple dual-nucleoside regimens. The most... Read more »
Connect With Others

does this mean you have hiv when u have this hla

Posted by need2know01, 1 Reply
...have developed to be poor immunogens. As a counterapproach HIV vaccine strategy, we used epitope enhancement of a conserved HIV reverse transcriptase (RT) epitope for induction of antiviral protection in HLA-A2-transgenic mice mediated by human... Read more »

Green tea?

Posted by franfrog
...first time that EGCG has been studied in HIV. In 1989, Japanese researchers reported that EGCG may help block an enzyme called reverse transcriptase that slips HIV's genetic material into the host cell's DNA. ... Read more »

much needed answer from expert

Posted by Anonymous, 1 Reply
...has anyone ever heard of a lipa or lipador test being giving to test for hiv. please help when i look this up it said a lipa test was giving for drug resistant test for geneotyping or something like that. Read more »

To John In London

Posted by une_fille, 1 Reply
hi there. i've never even heard of a bdna. i've had a dna at i think it was 7 weeks past exposure and i've had a negative 3 month elisa (3rd generation). i'm concerned what you said about the bdna, that it picks up strains found in europe and not... Read more »