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Reverse Transcriptase Hiv Virus

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AIDS InfoNet

Non-Nucleoside Reverse Transcriptase Inhibitors in Development

Note: Several fact sheets describe drugs that are being tested against HIV: Fact Sheet 410 : nucleoside analog reverse transcriptase inhibitors (nukes) Fact Sheet 440 : protease inhibitors Fact Sheet 460 : attachment and fusion inhibitors Fact Sheet 470 : new classes of antiretroviral drugs Fact Sheet 480 : immune therapies These drugs have not been approved by the Food and Drug Administration (FDA) for use against HIV. ...
Ask the Experts

reverse transcriptase

What is reverse transcriptase and how does it work?...
Mark Holodniy, M.D., F.A.C.P., C.I.C.

Response from Mark Holodniy, M.D., F.A.C.P., C.I.C.

Stanford University, School of Medicine
Reverse transcriptase is an enzyme (or protein) that the HIV virus carries to make a DNA copy of itself once it gets inside a cell. This DNA copy can then get inside the cell nucleus and become incorporated into the human cell DNA. The enzyme takes... Read more »

Reverse transcriptase inhibitors effect on telomeres

I recently started on Atripla and was trying to understand how it works and potential long term effects. So as I understand it (and I'm not a microbiologist by any stretch) the main purpose of the Sustiva in Atripla is to inhibit the reverse...
Keith Henry, M.D.

Response from Keith Henry, M.D.

University of Minnesota, School of Medicine
I am not aware of any data that has shown that nucleoside reverse transcriptase inhibitors (that are HIV DNA chain terminators not directly involving human DNA) clinically impact human chromosome or telomore length/function. Non-nucleoside RT... Read more »

Testing for Reverse Transcriptase

Dear Dr. Holodniy, I have a question regarding the enzyme reverse transcriptase. Is the enzyme present in all HIV infections, as well as other retroviruses. If so, how do you test for the enzyme in a patient?Thanks a lot....
Mark Holodniy, M.D., F.A.C.P., C.I.C.

Response from Mark Holodniy, M.D., F.A.C.P., C.I.C.

Stanford University, School of Medicine
THe enzyme is present in all HIV infections and other retroviral infections. We don't normally test for the RT or RT activity directly. A western blot test, will detect antibodies that have developed against the RT part of the virus. A new test... Read more »

Reverse Transcriptase-Is it only related to retrovirus's?

Good day,I sort of understand how rt works and the mechanism nukes and nonnukes work in it's lifecycle to interupt repliction.I am confused about a few things though.Is rt carried out by an enzyme, and is this enzyme needed by the body to carry...
Mark Holodniy, M.D., F.A.C.P., C.I.C.

Response from Mark Holodniy, M.D., F.A.C.P., C.I.C.

Stanford University, School of Medicine
Reverse transcriptase is not a normal enzyme in the human body. Although the HIV drugs affect the function of this viral enzyme specifically, they are close cousins to the building blocks needed to make DNA by a human cell. We are just beginning to... Read more »
Connect With Others

Prezista - New PI designed for Resistant Virus

Posted by Survivor, 2 Replies
WASHINGTON, June 23 (Reuters) - U.S. health officials on Friday approved the use of a new HIV drug, made by Johnson & Johnson <JNJ.N>, in combination with related therapies to help treat patients who do not first improve with other... Read more »

reversing lipodystrophy....

Posted by Anonymous, 1 Reply
Positive since 2003 full blown aids. Was on Kaletra and combivir. Reached non-detectable, and cd4 rising as expected. Into 3rd year noticing increase in truncal girth. Waist went from 27in. to 32in of hard solid protruding fat. Arms, legs, face... Read more »

Is there any test which look for HIV virus itself

Posted by Anonymous, 1 Reply
Hi everybody I am wondering is there some kind of test which look for virus itself?
I am becoming paranoid about hiv i tested 8 months after my last sex and i am still woried becouse i started doubting everything medicine science even my own body.
Read more »

space shuttels vs hiv virus ??..

Posted by umavanukuri
space shuttels lands on moon and moves at upper atmosphere, hiv virus touches cd4 cells and does work spoiling the cells and eventually immune system Read more »