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Spotlight Series: HIV Stigma and Discrimination

Reverse Transcriptase Hiv Virus

Here's a taste of what has to offer on this topic:
Get the Facts
AIDS InfoNet

Non-Nucleoside Reverse Transcriptase Inhibitors in Development

... Non-Nucleoside Reverse Transcriptase Inhibitors NNRTIs in Development NNRTIs No Longer in Development Note: Several fact sheets describe drugs that are being tested against HIV: Fact Sheet 410 : nucleoside analog reverse transcriptase inhibitors (nukes)
Ask the Experts

Reverse transcriptase inhibitors effect on telomeres

I recently started on Atripla and was trying to understand how it works and potential long term effects. So as I understand it (and I'm not a microbiologist by any stretch) the main purpose of the Sustiva in Atripla is to inhibit the reverse...
Keith Henry, M.D.

Response from Keith Henry, M.D.

University of Minnesota, School of Medicine
...I am not aware of any data that has shown that nucleoside reverse transcriptase inhibitors (that are HIV DNA chain terminators not directly involving human DNA) clinically impact human chromosome or telomore Read more »

Dr Bob Beck's cure for AIDS and cancer

Hello there!Just want to find out what's your take on Dr Bob Beck's method of curing AIDS and other diseases? How come it is not being promoted anywhere? I hope you won't tell me you don't know about it cause it's all over the media. There are a...
Joseph McGowan, M.D., F.A.C.P.

Response from Joseph McGowan, M.D., F.A.C.P.

North Shore University Hospital
...alter and inhibit the ability of the outer protein layer of the virus to attach to lymphocyte receptor sites and interrupts the reverse transcriptase process. This is thought to block the binding of the HIV virus with the host cell (Thymic-T... Read more »

HIV Mutation

At what point in the HIV life cycle does the mutation occur? Does the mutation occur before the HIV reaches the nucleous or after?
Joseph McGowan, M.D., F.A.C.P.

Response from Joseph McGowan, M.D., F.A.C.P.

North Shore University Hospital cycle, it must convert it's RNA gene into a DNA gene. This is done by a protein that the virus carries with it called Reverse Transcriptase. Mutations occur when Reverse Transcriptase converts the gene from RNA to DNA. This happens in the... Read more »

reverse transcriptase

What is reverse transcriptase and how does it work?
Mark Holodniy, M.D., F.A.C.P., C.I.C.

Response from Mark Holodniy, M.D., F.A.C.P., C.I.C.

Stanford University, School of Medicine
...Reverse transcriptase is an enzyme (or protein) that the HIV virus carries to make a DNA copy of itself once it gets inside a cell. This DNA copy can Read more »
The Body PRO

Session 84, Abstract 664: Therapy with d4T plus 3TC Produces Sustained Undetectable Levels of Plasma HIV RNA in Patients Treated with Reverse Transcriptase (RT) Inhibitors for 10 Years

...interesting conclusions worthy of further study. The researchers indeed found that certain patients who have received long-term reverse transcriptase inhibitor therapy may still benefit from relatively simple dual-nucleoside regimens. The most... Read more »
The Body PRO

Abstract No. 116: Mutations in the Reverse Transcriptase Genome of HIV I Isolates Derived from Subjects Treated with Didanosine and Stavudine in Combination

...with DDI and d4T in combination. Finally, the authors summarize that the data highlights the complex relationship between HIV I phenotypic and phenotypic resistance and HIV viral loads in individuals treated with dual nucleoside combinations.... Read more »
The Body PRO

Clinical Trials of HIV-1 Reverse Transcriptase Inhibitors

...Hammer, S. Liou, R. Bosch, and D. Katzenstein View the original abstract We try to use as few agents as possible to suppress HIV in order to preserve agents for future use and limit toxicity. Current thought involves the use of three or... Read more »
The Body PRO

New Insights Into Mechanisms of HIV-1 Resistance to Reverse Transcriptase Inhibitors (Plenary Session 22)

...original abstract Dr. Mellors presented a thorough review of the biochemical and structural relationship of resistance to reverse transcriptase (RT). After HIV infects a cell, the viral RNA must be reverse transcribed by the HIV reverse... Read more »
Connect With Others

Prezista - New PI designed for Resistant Virus

Posted by Survivor, 2 Replies
...breakdown of Prezista in the body, increasing its concentration in a patient's system, the Food and Drug Administration said. The human immunodeficiency virus that causes AIDS infects close to 40 million people worldwide, with more than 1... Read more »

Vasculitis and HIV

Posted by Anonymous, 3 Replies
...Does anyone know about vasculitis and HIV? Read more »

does this mean you have hiv when u have this hla

Posted by need2know01, 1 Reply
...have developed to be poor immunogens. As a counterapproach HIV vaccine strategy, we used epitope enhancement of a conserved HIV reverse transcriptase (RT) epitope for induction of antiviral protection in HLA-A2-transgenic mice mediated by human... Read more »

Rutgers researchers may have stopped HIV

Posted by Anonymous, 7 Replies
...molecules, the smallest particles that can retain all the characteristics of an element or compound. The research has targeted reverse transcriptase, a submiscroscopic protein composed of two coiled chains of amino acids. It is considered HIV's... Read more »