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Reverse Transcriptase Inhibitor Drugs

Here's a taste of what has to offer on this topic:
Get the Facts
AIDS InfoNet

Non-Nucleoside Reverse Transcriptase Inhibitors in Development

... Non-Nucleoside Reverse Transcriptase Inhibitors NNRTIs in Development NNRTIs No Longer in Development Note: Several fact sheets describe drugs that are being tested against HIV: Fact Sheet 410 : nucleoside analog reverse transcriptase inhibitors (nukes) Fact
Ask the Experts

Reverse transcriptase inhibitors effect on telomeres

I recently started on Atripla and was trying to understand how it works and potential long term effects. So as I understand it (and I'm not a microbiologist by any stretch) the main purpose of the Sustiva in Atripla is to inhibit the reverse...
Keith Henry, M.D.

Response from Keith Henry, M.D.

University of Minnesota, School of Medicine
...I am not aware of any data that has shown that nucleoside reverse transcriptase inhibitors (that are HIV DNA chain terminators not directly involving human DNA) clinically impact human chromosome or telomore length/function. Read more »

Sleeping tablets and meds

I read somewhere that they do affect absorption of protease inhibitors, what about transcriptase inh? Could they aso have a direct effect on inmune system? Thank you
John A. Bartlett, M.D.

Response from John A. Bartlett, M.D.

Duke University Medical Center
...Sleeping pills, the protease inhibitors and the non-nucleoside reverse transcriptase inhibitors can have drug interactions. Be sure to review these possibilities with your health care provider. The nucleoside reverse transcriptase Read more »

feeling weak and hopeless

Goodmorning Dr. I'm Angelo writing from Goa, India Please please I need your help to put myself right back to a healthier and happy life. In feb.2005 I started my first regimen caled Triomune(lamaudine, stauvdine, Nevimune)With this I really felt on...
Robert J. Frascino, M.D.

Response from Robert J. Frascino, M.D.

The Robert James Frascino AIDS Foundation
...completely.2.You've continued on stavudine (D4T) as one of the antiretrovirals in your regimen. D4T is a thymidine analog nucleoside reverse transcriptase inhibitor drug that has been linked to lipoatrophy (loss of fat in the face, buttocks and... Read more »

New Developement

Please what new developments are there as per drugs and treatment that might bring final solution in the near future. thanks.
Robert J. Frascino, M.D.

Response from Robert J. Frascino, M.D.

The Robert James Frascino AIDS Foundation
...widespread use with the availability of potent new drugs, particularly protease inhibitors (PI's). PI's in combination with our reverse transcriptase inhibitor drugs (RTIs) dramatically decreased HIV/AIDS morbidity and mortality. Now, after a... Read more »
AIDS InfoNet

Nucleoside Analog Reverse Transcriptase Inhibitors in Development

... Nucleoside Analog Reverse Transcriptase Inhibitors Nucleoside Analogs (Nukes) in Development Nukes No Longer in Development NOTE: Several fact sheets describe drugs that Read more »
The Body PRO

Pharmacokinetics of MKC-422, One of the Next Non-nucleoside Reverse Transcriptase Inhibitors, Together with ZDV, 3TC, d4T, and ddI metabolized by the cytochrome P450 liver enzyme CYP3A4, the enzyme responsible for metabolizing the other non-nucleoside reverse transcriptase inhibitors as well as the protease inhibitors. Other NNRTIs and protease inhibitors have not been... Read more »
U.S. Centers for Disease Control and Prevention

United Kingdom: "Virological and Immunological Outcomes at 3 Years After Starting Antiretroviral Therapy with Regimens Containing Non-Nucleoside Reverse Transcriptase Inhibitor, Protease Inhibitor, or Both in INITIO: Open-Label Randomized Trial"

...-- a large international randomized trial -- the study authors compared antiretroviral therapy with two nucleoside analogue reverse transcriptase inhibitors (didanosine + stavudine) plus either a non-nucleoside reverse transcriptase inhibitor... Read more »
The Body PRO

Some Nucleoside Reverse Transcriptase Inhibitors Are Relatively Concentrated in Seminal Fluid, but Does It Matter?

...drug exposure (area under-the-cure, AUC). These data confirm previous, less rigorous studies that suggest certain nucleoside reverse transcriptase inhibitors are relatively concentrated in seminal fluid -- an important location for antiviral... Read more »
Connect With Others

Lab, med change, confusion

Posted by kaplan08, 2 Replies
Labs of last year have shown a vload range between <400 and 793, with <400 being most recent; CD4 percentage range from 31% to 34%, with 33% being most recent. Taking only Viramune and Combivir -a test has recently shown resistance to... Read more »

Prezista - New PI designed for Resistant Virus

Posted by Survivor, 2 Replies J&J's HIV franchise, which aims to combat HIV drug resistance Prezista will be followed by TMC125, a non-nucleoside reverse transcriptase inhibitor typically used in combination with other drugs expected to be launched in late 2008. That... Read more »

Should i Start medication???

Posted by coconyc, 3 Replies
Hi im Coco from nyc I though the benefit or getting tested its to find out the virus in a early time so u can get a good treatment that prolong ur life in a better condition, i got my first results a month ago and i got CD4:276 and VL: 3616, so my... Read more »

DDC Bites the Dust

Posted by Bear60, 1 Reply
...Pharmaceuticals announced that it will be ending the sale and distribution of Hivid (zalcitabine, also known as ddC), a nucleoside reverse transcriptase inhibitor (NRTI) originally approved in 1992. The tablets will not be available in U.S.... Read more »