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Spotlight Series: HIV Stigma and Discrimination

Receptors And Cells Utilized By Hiv

Here's a taste of what has to offer on this topic:
Get the Facts
The Well Project

HIV Drugs and the HIV Lifecycle

...virus. Thesteps HIV goes through to complete this process are as follows: Binding and Fusion HIV begins to enter a CD4 cell by binding (or attaching) itself to aspecific point, called a CD4 receptor, on the cell's surface. HIV must thenbind to a second co-receptor, either the CCR5 co-receptor or the CXCR4co-receptor. This allows the virus to join with the CD4 cell in a processcalled fusion. After fusion, HIV releases...
Ask the Experts

T cell receptor

I know that at Boston Massachusetts General Hospital, they are ready to start a clinical trial to test a new chemio-molecules targeting specifically hiv infected cells, even the latent reservoirs.Do you think thatT-cell receptor may be used as a...
Graeme Moyle, M.D.

Response from Graeme Moyle, M.D.

Chelsea and Westminster Hospital
I am not aware of this trial so do not feel qualified to comment. I would suggest contacting Mass General to find out more and volunteerSorry not to be much useDr Moyle Read more »

genetically engineer immune cells into potent weapons for battling HIV (CTL, GENE THERAPY)

I would love to know what you think about this.................Einstein researchers genetically engineer immune cells into potent weapons for battling HIVMarch 4, 2008 (Bronx, NY) By outfitting immune-system killer cells with a new pair of genes,...
Robert J. Frascino, M.D.

Response from Robert J. Frascino, M.D.

The Robert James Frascino AIDS Foundation
...Hi,This is extremely interesting and important work. As an immunologist, I have advocated immune-based therapies for HIV treatment and, ultimately, cure since the early days of the epidemic. It's becoming clearer that despite truly remarkable... Read more »

A Thought that can change lives of Many HIV Patients

Can you guide me if following can be tried out on HIV patients, I have read a lot about mature T4 cells being replicated and grown outside the body.. Also I have read lot about defective co-receptors surface areas of T4 cells which do not allow HIV...
Mark Holodniy, M.D., F.A.C.P., C.I.C.

Response from Mark Holodniy, M.D., F.A.C.P., C.I.C.

Stanford University, School of Medicine
...cells into a human host will not work with drugs to suppress a person's immune system (like in organ transplantation) because the cells would be destroyed by the host. Second, some approaches to this problem are being studied. But they utilize... Read more »

Did you mean HIV+?

Dear Dr. Holodniy,In your response to "What does CD4% mean" you write that "CD4% is the percentage of lymphocytes that are CD4+." I am scratching my head. Did you mean "HIV+" instead of "CD4+" or are there "CD4+" cells?Thank you.
Mark Holodniy, M.D., F.A.C.P., C.I.C.

Response from Mark Holodniy, M.D., F.A.C.P., C.I.C.

Stanford University, School of Medicine
...The answer is as I stated. CD4+ does NOT mean HIV infected. It means the cells are positive for having CD4 receptors on the cell surface. We can detect those receptors using special test reagents to determine Read more »
University of California-Los Angeles

UCLA Researchers Demonstrate That Stem Cells Can Be Engineered to Kill HIV

... Researchers from the UCLA AIDS Institute and colleagues have for the first time demonstrated that human blood stem cells can be engineered into cells that can target and kill HIV-infected cells -- a process that potentially could be used against Read more »
The Body

The Alphabet Soup of Immune Control: ADCC Antibodies, (Memory) B-Cells, Elite Controllers and Exposed Sero-Negatives -- Will They Amount to Z?

...apoptosis. Vpu is a HIV gene. Vpu stands for "Viral Protein U." Vpu is involved in viral budding, enhancing virion release from the cell by counteracting BST2 (also known as tetherin). It can be found in HIV-1 but not in HIV-2. [Source: ... Read more »
The Well Project

Understanding HIV-Related Lab Tests II: Viral Load, Resistance and Tropism

...cells in your bodycalled CD4 cells. In order to enter a CD4 cell, HIV attaches itself toreceptors on the outside (surface) of the cell. Each CD4 cell has a CD4 receptor and two co-receptors called CCR5 and CXCR4on its surface. To enter the CD4... Read more »
AIDS InfoNet

Tropism Tests

...With the Tropism Test? What Is Viral Tropism? When HIV attaches to a CD4 cell it is going to infect, it uses molecules on the cell surface. These are called receptors or chemokine co-receptors. The first receptor HIV uses is the CD4... Read more »
Connect With Others


Posted by Anonymous, 1 Reply
...findings may also advance the scientific foundation for a potential HIV treatment that may block the virus that causes AIDS. The cell culture study by a research team from The Children's Hospital of Philadelphia and the University of... Read more »

How Soon Should T-Cell Count Increase?

Posted by Anonymous, 5 Replies
...originally 318 when I was diagnosed and it has only gone up to 340 after the same period of meds treatment. Is it normal for T-cells to take that long to recover/increase when my viral load seems to be doing so well/coming down so fast? Anyone... Read more »


Posted by Anonymous, 1 Reply
Jackie, what is the mutated CCR5?? Is it a different strain or what? Read more »

immune system

Posted by Anonymous, 1 Reply
...thing as a lentivirus? What is DNA? Who is OJ? Am I asking too many questions? Is is ok to laugh when you are depressed over hiv? Please respond to any or all of the above. Read more »