Reaction To Protease Inhibitors

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Protease Inhibitors in Development

These drugs have not been approved by the Food and Drug Administration (FDA) for use against HIV. Protease Inhibitors These drugs block the protease enzyme. When new viral particles break off from an infected cell, protease cuts long protein strands into the parts needed to assemble a mature virus. When protease is blocked, the new viral particles cannot mature. Protease Inhibitors in Development Several firms are trying to develop a new...

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Protease Inhibitors and Sulfa Allergy

I saw the question about protease inhibitors and sulfa allergies in your newsletter. Fifteen years ago I was hospitalized for ten days after having a severe allergic reaction to Bactrim. Given my history, I was worried about starting Aptivus in...

Response from Keith Henry, M.D.

University of Minnesota, School of Medicine

Thanks for posting your experience on the matter. KH... Read more »

A change from Protease Inhibitors?

I am hoping to change treatment because of side effects and am seeking your advice.I originally started with Combivir & Sustiva with a CD4 of 200 and VL > 10^6, however changed after 11 months due to problem sleeping / nightmares and the...

Response from David Wohl, M.D.

University of North Carolina - Chapel Hill

I have several thoughts.First, your GI symptoms may well be due to ritonavir as they began with the initiation of this medication. A regimen that spares ritonavir might be the ticket for you. I would consider a switch to Reyataz (400 mg a day)... Read more »

Protease Inhibitors vs. Triple Nucleosides

In late June my doctor gave me the option to change my HIV medication to Trizivir, from Viracept and Combivir. The dosage (two pills a day as opposed to twelve pills a day), was very tempting. I questioned him about the lack of a protease inhibitor...

Response from Cal Cohen, M.D., M.S.

Harvard Medical School

A few comments to see what I can do to clarify what you've read.First - the guidelines. They do comment on some of the protease inhibitors that they recommend as part of a first combination, such as Viracept. They also comment on other... Read more »

garlic/protease inhibitors

someone told me that if you take a protease inhibitor-than you shouldnot take garlic. is this true?...

Response from David Wohl, M.D.

University of North Carolina - Chapel Hill

There are concerns that garlic in sufficient quantities can interfer with certain HIV drugs. This is best described fo rteh protease inhibitor saquinavir (Fortovase, Invirase) but may hold true for other drugs in and outside of this drug class.One... Read more »

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lipodystrophy from protease inhibitors

Posted by Anonymous, 4 Replies

I have known about my HIV+ status now for 6 years, and God has blessed me with continued good health. I have accessed all the major medications, plus vitamins to help fight the disease. Once I started taking the new protease inhibitors, I started... Read more »

bone density loss due to protease inhibitors

Posted by Anonymous, 1 Reply

Curious as to latest info. on research into bone density loss due to HAART therapy. Most research data i've seen goes back to 99 or 2000. Any new data/research into this? Also any info. on clinical trials currently under way looking into this... Read more »

Hyperglycemia as a result of Protease Inhibitors

Posted by Anonymous

I found a product for reducing glucose levels. It is called Meishan Tea. They make 4 different kinds of tea and I have people that are showing tremendous results on all 4 kinds. However, the people that are presently taking the tea do not have AIDS.... Read more »

Protease Inhibitors - Hemophilia bleeds

Posted by akcol

Hi, my fiance is a Long Term NonProgressor - 24 years positive, co-infection HCV, with severe Hemophilia A.

This is a question for the gentlemen with Hemophilia please.
We're requesting any input about any Hemophilic PI increased unusual bleed... Read more »

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