Reaction To Integrase Inhibitors

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An Overview of Isentress (Raltegravir, MK-0518)

ral-TEG-ra-vir Brand Name: Isentress Other Name(s): MK-0518, MK0158, RAL Drug Class: Integrase Inhibitors ISENTRESS ® ( eye sen tris ) ( raltegravir) Tablets Read the patient information that comes with ISENTRESS before you start taking it and each time you get a refill. There may be new information. What is ISENTRESS? ISENTRESS is an anti-HIV (antiretroviral) medicine used for the treatment of HIV. The term HIV...

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New Integrase inhibitor and lipodystrophy risk

There is a once a day integrase inhibitor with a non-PI booster coming up soon, isn't there? What is the integrase inhibitor called and what class does the booster belong to? Setting aside the relative newness of these drugs (and therefore the...

Response from Gerald Pierone, M.D.

AIDS Research and Treatment Center of the Treasure Coast

Hello and thanks for posting. The new integrase inhibitor medication is called elvitegravir and the booster is GS 9350. The booster is one of a new class of drugs designed specifically to inhibit the CYP3A liver enzyme system. We already know that... Read more »

Integrase Inhibitor

Dr. Young, I am very interested to hear your thoughts on Integrase Inhibitors. -Do you think they will be successful in developing one? -Do you think it can be potentially used as a monotherapy?-Generally what are your thoughts?...

Response from Benjamin Young, M.D., Ph.D.

Rocky Mountain CARES

Thanks for your questions.Inhibitors of HIV integrase have been under investigation for some time, though none are currently in advanced clinical trials. There have been a couple of aborted candidate compounds, one from Merck, another from... Read more »

integrase inhibitor

i know that integrase inhibitor are doing very very well..the results are very impressive given the higly drug resistant popolation studied.I realize that the new integrase drugs reduced the viremia because there are less cell infect ( the virus...

Response from Benjamin Young, M.D., Ph.D.

Rocky Mountain CARES

Thanks for your post.Integrase inhibitors prevent the incorporation (or integration) of the HIV chromosome into the human (CD4 cell) chromosome. There are several integrase inhibitors in various stages of development. By doing so, it's... Read more »

Merck integrase inhibitor

Dear Doctor,You wrote a couple of days ago that the Merck integrase inhibitor will be available shortly. As a treatment experienced hiver (+ since 1990) I would like to know what this med will offer in comparison to the already available...

Response from David Wohl, M.D.

University of North Carolina - Chapel Hill

This will be a medication that works completely differently than any of the currently available HIV meds. Therefore, for someone like yourself who has had HIV for a while and may have virus that has accumulated HIV drug resistance, the integrase... Read more »

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Integrase Inhibitor

Posted by Survivor

I just wanted people realize there is hope and continued very active DRUG DISCOVERY!

Merck, Gilead Release Strong Findings From Clinical Trials of Experimental Integrase Inhibitor Antiretroviral Drugs

Whitehouse Station, N.J.-based Merck and Foster... Read more »