Reaction To NNRTIs

Here's a taste of what TheBody.com has to offer on this topic:

Articles

Drug Watch: Next-Generation NNRTIs: Etravirine and Rilpivirine

Why Do We Need More NNRTIs? Leading the Next Generation: Etravirine and Rilpivirine Etravirine: The DUET Studies Rilpivirine Implications for Treatment Selected Sources Even in patients with the most resistant virus, our goal now is full... Read more »

Know Your HIV Drugs: NNRTIs

Non-Nucleoside Reverse Transcriptase Inhibitors (NNRTIs) NNRTIs are another class of FDA-approved HIV antiviral drugs. There are currently three drugs approved for use in this class. NNRTIs work by targeting the structure of reverse transcriptase... Read more »

NNRTIs: The Next Generation Approaches

Part I Introduction Mechanisms of NNRTI Activity and HIV NNRTI Resistance NNRTI Resistance in NNRTI-Naive and NNRTI-Experienced Individuals NNRTI Mutations: Resistance and Cross-Resistance NRTI Mutations: The Potential Impact on NNRTIs NNRTI... Read more »

Ask the Experts

NNRTIs

Are either of the newer NNRTIs, Edurant or Intelence processed differently by the liver than the older drug Viramune? I have been on Viramune for more than 10 years just wondering of switching to one of the newer ones would be considered more...

Response from Keith Henry, M.D.

University of Minnesota, School of Medicine

The major liver concern with nevirapine is early on treatment. After 10 years the rate of liver problems on nevirapine would be expected to be low. Though etravirine and rilpivirine may be viewed as being more liver friendly there is minimal very... Read more »

Sustiva causing resistance to other nNRTIs

Sustiva (efavirenz)-Induced Mutation in Subtype C HIV May Confer Multi-NNRTI ResistanceA mutation at codon 106 in HIV-1 clade C viruses that occurs after exposure to efavirenz appears to result in high-level resistance to other non-nucleotide...

Response from Benjamin Young, M.D., Ph.D.

Rocky Mountain CARES

Thanks for pointing out the research.So far, this does not seem like a very common issue-- however, a different mutation at codon 103 is commonly found among persons with clade B HIV (the US, Western Europe flavor)- this mutation usually causes high... Read more »

NNRTIs and lipitor

What is your feeling about Lipitor to lower cholesterol in patients on nnrti regimens? I've been on Sustiva/Truvada for 14 weeks with great results but have been battling high cholesterol for about 10 years, HDL high, LDL low, well controlled...

Response from Mark Holodniy, M.D., F.A.C.P., C.I.C.

Stanford University, School of Medicine

Lipitor and other statins are not on the absolutely contraindicated list on the FDA approved package insert for sustiva. With anything you just need to be careful and have close followup.... Read more »

Lymph Node reaction(s)

You speak alot of lymph nodes possibly being painful when they are infected/enlarged. However, you do not indicate for long long it can be painful for. Can the lymph node(s) in question be painful for only maybe 3 seconds to 2 or 3 minutes, and...

Response from Mark Holodniy, M.D., F.A.C.P., C.I.C.

Stanford University, School of Medicine

No, swollen glands would not have fleeting symptoms like that.... Read more »

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Connect With Others

my strange reaction

Posted by midwestguy143, 2 Replies

I tested positive on March 24, 2009. The thing that surprised me, and my friends was my reaction -- none really. Just something else in my life. I had lost my job many months ago, and with the job market being so tough, I've gotten used to the... Read more »

allergic reactions

Posted by TRex, 2 Replies

Has anyone who is HIV positive had a lot of allergic reactiosn to antibiotics? I had two allergic reactions (the Bactrim one was the one who made me ask for the HIV test).the other one is Keflex. I am on Augmentin now and woke up with another... Read more »

antibiotic reaction

Posted by princealbert

After one week on augmentin, a pick line and beginning IV antibiotics (only one dose), I had a horrible drug reaction.
But four days later, I still walk around itchy and red, feeling like I just rolled around in poison ivy.
Has anyone else had a bad... Read more »

antibiotic reaction

Posted by princealbert, 2 Replies

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