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Protease Inhibitor Signaling Pathway And Cancer

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AIDS InfoNet

Protease Inhibitors in Development

These drugs have not been approved by the Food and Drug Administration (FDA) for use against HIV. Protease Inhibitors These drugs block the protease enzyme. When new viral particles break off from an infected cell, protease cuts long protein strands into the parts needed to assemble a mature virus. When protease is blocked, the new viral particles cannot mature. Protease Inhibitors in Development Several firms are trying to develop a new...
Ask the Experts

Xanax and protease inhibitors

I was diagnosed several years ago with panic disorder and have managed well to keep it under control with the use of xanax from time to time when stress gets really bad. But I understand that there is a concern about using xanax when using a...
John A. Bartlett, M.D.

Response from John A. Bartlett, M.D.

Duke University Medical Center
The issue with Xanax and protease inhibitors is the prolongation of the Xanax drug levels (and effects). Both drugs are metabolized by the same pathway in the liver, so that your Xanax will stay with you longer when you are taking a PI. The same... Read more »

methadone interactions with protease inhibitors/particularly reyataz

i have some very severe neourapathy which has led me to take methadone. I have been fortunate to not need the use of protease inhibitorstill now.Actually , i was on kaletra for a short period of time but found that i started feeling withdrawal...
Keith Henry, M.D.

Response from Keith Henry, M.D.

University of Minnesota, School of Medicine
Indinavir, ritonavir (Decrease methadone levels about 37%), saquinavir (decrease methadone levels about 20%), nelfinavir, Kaletra (decrease methadone levels about 50%) have been evaluated with little evidence of withdrawal and are said to be OK to... Read more »

Interactions of Protease Inhibitors and Blood Pressure Medications

I was recently placed on Tekturna and HCT to treat my blood pressure, and pravastatin for the P.I. increased cholesterol.Initially, the Tekturna dose of 150mg (the lowest prescription) seemed to create a neuropathy sensation on my left leg and arm....
Keith Henry, M.D.

Response from Keith Henry, M.D.

University of Minnesota, School of Medicine
I have seen no formal drug interaction studies with protease inhibitors and Aliskiren but the potential for interaction seems real.Aliskiren can cause muscle irritation in a small subset of patients. It is cleared from the body by the liver and that... Read more »

Hypogonadism from protease inhibitors

I am a 33-yr-old male who was diagnosed two years ago during my seroconversion illness, and immediately began triple cocktail therapy with Crix/AZT/3TC, and have remained undetectable since that first diagnostic viral load test. After 13 months of...
J. B. Molaghan, N.P., A.C.R.N.

Response from J. B. Molaghan, N.P., A.C.R.N.

San Francisco General Hospital
HelloThanks for such a nicely detailed clinical summary. Although we assume that hypogonadism is only associated with HIV disease progression, we don't really know if it occurred in early HIV disease, because we never looked for it. In fact,... Read more »
Connect With Others

lipodystrophy from protease inhibitors

Posted by Anonymous, 4 Replies
I have known about my HIV+ status now for 6 years, and God has blessed me with continued good health. I have accessed all the major medications, plus vitamins to help fight the disease. Once I started taking the new protease inhibitors, I started... Read more »

bone density loss due to protease inhibitors

Posted by Anonymous, 1 Reply
Curious as to latest info. on research into bone density loss due to HAART therapy. Most research data i've seen goes back to 99 or 2000. Any new data/research into this? Also any info. on clinical trials currently under way looking into this... Read more »

Hyperglycemia as a result of Protease Inhibitors

Posted by Anonymous
I found a product for reducing glucose levels. It is called Meishan Tea. They make 4 different kinds of tea and I have people that are showing tremendous results on all 4 kinds. However, the people that are presently taking the tea do not have AIDS.... Read more »

Protease Inhibitors - Hemophilia bleeds

Posted by akcol
Hi, my fiance is a Long Term NonProgressor - 24 years positive, co-infection HCV, with severe Hemophilia A.

This is a question for the gentlemen with Hemophilia please.
We're requesting any input about any Hemophilic PI increased unusual bleed... Read more »