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Protease Inhibitor Drug Interactions

Here's a taste of what TheBody.com has to offer on this topic:
Articles
Merck & Co., Inc.

Important Drug Warning: Results of Pharmacokinetic Study in Healthy Volunteers Given Victrelis (Boceprevir) and Ritonavir-Boosted HIV Protease Inhibitors May Indicate Clinically Significant Drug Interactions for Patients Coinfected With Chronic Hepatitis C and HIV

Dear Health Care Professional, The purpose of this communication is to inform you of recent pharmacokinetic study results evaluating drug interactions between VICTRELIS, an oral chronic hepatitis C virus (HCV) NS3/4A protease inhibitor, and... Read more »
U.S. Food and Drug Administration

Updated Information on Drug Interactions Between Victrelis (Boceprevir) and Certain Boosted HIV Protease Inhibitor Drugs

This update is in follow-up to the "FDA Drug Safety Communication: Important Drug Interactions Between Victrelis (Boceprevir) and Ritonavir-Boosted Human Immunodeficiency Virus (HIV) Protease Inhibitor Drugs " on 2/8/2012. Safety Announcement ... Read more »
U.S. Food and Drug Administration

FDA Drug Safety Communication: Important Drug Interactions Between Victrelis (Boceprevir) and Ritonavir-Boosted Human Immunodeficiency Virus (HIV) Protease Inhibitor Drugs

Safety Announcement Facts About Victrelis (Boceprevir) and HIV Protease Inhibitors Victrelis is a hepatitis C virus (HCV) protease inhibitor used with the medicines peginterferon alfa and ribavirin to treat chronic (long-lasting) hepatitis C... Read more »
Ask the Experts

Interactions of Protease Inhibitors and Blood Pressure Medications

I was recently placed on Tekturna and HCT to treat my blood pressure, and pravastatin for the P.I. increased cholesterol.Initially, the Tekturna dose of 150mg (the lowest prescription) seemed to create a neuropathy sensation on my left leg and arm....
Keith Henry, M.D.

Response from Keith Henry, M.D.

University of Minnesota, School of Medicine
I have seen no formal drug interaction studies with protease inhibitors and Aliskiren but the potential for interaction seems real.Aliskiren can cause muscle irritation in a small subset of patients. It is cleared from the body by the liver and that... Read more »

methadone interactions with protease inhibitors/particularly reyataz

i have some very severe neourapathy which has led me to take methadone. I have been fortunate to not need the use of protease inhibitorstill now.Actually , i was on kaletra for a short period of time but found that i started feeling withdrawal...
Keith Henry, M.D.

Response from Keith Henry, M.D.

University of Minnesota, School of Medicine
Indinavir, ritonavir (Decrease methadone levels about 37%), saquinavir (decrease methadone levels about 20%), nelfinavir, Kaletra (decrease methadone levels about 50%) have been evaluated with little evidence of withdrawal and are said to be OK to... Read more »

wellbutrin and protease inhibitors

I always check The Body for info on treatments and read that caution should be used when taking Wellbutrin with Protease Inhibitors. I was recently changed from zoloft to Wellbutrin and I currently take Viracept, Epivir, and Zerit. Should I be...
Keith Henry, M.D.

Response from Keith Henry, M.D.

University of Minnesota, School of Medicine
There is concern about drug interaction between Wellbutrin and PIs (especially ritonavir). The potential for interaction with Viracept seems to be less-I have used the two drugs together. I watch carefully for adverse effects when those two drugs... Read more »

What is it about protease inhibitors anyway?

Since it seems like protease inhibitors are one big problem in lipodystrophy, what is it that a protease inhibitor does that is good? Also this may be naive on my part but if inhibiting protease is bad, why wouldn't fostering protease be good?...
Graeme Moyle, M.D.

Response from Graeme Moyle, M.D.

Chelsea and Westminster Hospital
Inhibiting HIV protease, a key viral enzyme drammatically reduces viral load and began the revolution in HIV therapy that has saved so many lives in the developed world. Unfortunately, some members of this drug class interact with essential human... Read more »
Connect With Others

Hyperglycemia as a result of Protease Inhibitors

Posted by Anonymous
I found a product for reducing glucose levels. It is called Meishan Tea. They make 4 different kinds of tea and I have people that are showing tremendous results on all 4 kinds. However, the people that are presently taking the tea do not have AIDS.... Read more »

lipodystrophy from protease inhibitors

Posted by Anonymous, 4 Replies
I have known about my HIV+ status now for 6 years, and God has blessed me with continued good health. I have accessed all the major medications, plus vitamins to help fight the disease. Once I started taking the new protease inhibitors, I started... Read more »

bone density loss due to protease inhibitors

Posted by Anonymous, 1 Reply
Curious as to latest info. on research into bone density loss due to HAART therapy. Most research data i've seen goes back to 99 or 2000. Any new data/research into this? Also any info. on clinical trials currently under way looking into this... Read more »

Protease Inhibitors - Hemophilia bleeds

Posted by akcol
Hi, my fiance is a Long Term NonProgressor - 24 years positive, co-infection HCV, with severe Hemophilia A.

This is a question for the gentlemen with Hemophilia please.
We're requesting any input about any Hemophilic PI increased unusual bleed... Read more »