Protease Inhibitor Drug Interactions

Here's a taste of what TheBody.com has to offer on this topic:

Articles

Important Drug Warning: Results of Pharmacokinetic Study in Healthy Volunteers Given Victrelis (Boceprevir) and Ritonavir-Boosted HIV Protease Inhibitors May Indicate Clinically Significant Drug Interactions for Patients Coinfected With Chronic Hepatitis C and HIV

Dear Health Care Professional, The purpose of this communication is to inform you of recent pharmacokinetic study results evaluating drug interactions between VICTRELIS, an oral chronic hepatitis C virus (HCV) NS3/4A protease inhibitor, and... Read more »

FDA Drug Safety Communication: Important Drug Interactions Between Victrelis (Boceprevir) and Ritonavir-Boosted Human Immunodeficiency Virus (HIV) Protease Inhibitor Drugs

Safety Announcement Facts About Victrelis (Boceprevir) and HIV Protease Inhibitors Victrelis is a hepatitis C virus (HCV) protease inhibitor used with the medicines peginterferon alfa and ribavirin to treat chronic (long-lasting) hepatitis C... Read more »

Recreational Drugs, Methadone and Protease Inhibitors

Do protease inhibitors make heroin stronger or weaker? Every day brings a variety of questions to the Treatment Education Project, an initiative of the Staten Island AIDS Task Force. A common request is for information about protease inhibitors,... Read more »

Ask the Experts

Interactions of Protease Inhibitors and Blood Pressure Medications

I was recently placed on Tekturna and HCT to treat my blood pressure, and pravastatin for the P.I. increased cholesterol.Initially, the Tekturna dose of 150mg (the lowest prescription) seemed to create a neuropathy sensation on my left leg and arm....

Response from Keith Henry, M.D.

University of Minnesota, School of Medicine

I have seen no formal drug interaction studies with protease inhibitors and Aliskiren but the potential for interaction seems real.Aliskiren can cause muscle irritation in a small subset of patients. It is cleared from the body by the liver and that... Read more »

methadone interactions with protease inhibitors/particularly reyataz

i have some very severe neourapathy which has led me to take methadone. I have been fortunate to not need the use of protease inhibitorstill now.Actually , i was on kaletra for a short period of time but found that i started feeling withdrawal...

Response from Keith Henry, M.D.

University of Minnesota, School of Medicine

Indinavir, ritonavir (Decrease methadone levels about 37%), saquinavir (decrease methadone levels about 20%), nelfinavir, Kaletra (decrease methadone levels about 50%) have been evaluated with little evidence of withdrawal and are said to be OK to... Read more »

wellbutrin and protease inhibitors

I always check The Body for info on treatments and read that caution should be used when taking Wellbutrin with Protease Inhibitors. I was recently changed from zoloft to Wellbutrin and I currently take Viracept, Epivir, and Zerit. Should I be...

Response from Keith Henry, M.D.

University of Minnesota, School of Medicine

There is concern about drug interaction between Wellbutrin and PIs (especially ritonavir). The potential for interaction with Viracept seems to be less-I have used the two drugs together. I watch carefully for adverse effects when those two drugs... Read more »

HIV protease inhibitors

Could you tell me the spectrum of activity and the mechanism of resistance for the antimicrobial HIV protease inhibitors (Ex: Indinavir)and do they work with gram positve/gram negative bacteria. What bacteria does it work against. Or what sites I...

Response from Eric Daar, M.D.

UCLA School of Medicine

The HIV protease inhibitor selectively blocks the protease enzyme and prevents an infected cell from producing infectious HIV. Resistance develops when mutations emerge in the viral protease enzyme that prevent the inhibitor from interacting with... Read more »

Go to Ask the Experts »

Connect With Others

Hyperglycemia as a result of Protease Inhibitors

Posted by Anonymous

I found a product for reducing glucose levels. It is called Meishan Tea. They make 4 different kinds of tea and I have people that are showing tremendous results on all 4 kinds. However, the people that are presently taking the tea do not have AIDS.... Read more »

lipodystrophy from protease inhibitors

Posted by Anonymous, 4 Replies

I have known about my HIV+ status now for 6 years, and God has blessed me with continued good health. I have accessed all the major medications, plus vitamins to help fight the disease. Once I started taking the new protease inhibitors, I started... Read more »

bone density loss due to protease inhibitors

Posted by Anonymous, 1 Reply

Curious as to latest info. on research into bone density loss due to HAART therapy. Most research data i've seen goes back to 99 or 2000. Any new data/research into this? Also any info. on clinical trials currently under way looking into this... Read more »

Protease Inhibitors - Hemophilia bleeds

Posted by akcol

Hi, my fiance is a Long Term NonProgressor - 24 years positive, co-infection HCV, with severe Hemophilia A.

This is a question for the gentlemen with Hemophilia please.
We're requesting any input about any Hemophilic PI increased unusual bleed... Read more »

Connect on Our Bulletin Boards »

Tools

My Health Tracker

Assess Your Risk for HIV

Find Local HIV/AIDS Services

Resource Centers

Guides for People With HIV

View All of Our Guides >>