Protease Inhibitor Dosing

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Protease Inhibitors in Development

These drugs have not been approved by the Food and Drug Administration (FDA) for use against HIV. Protease Inhibitors These drugs block the protease enzyme. When new viral particles break off from an infected cell, protease cuts long protein strands into the parts needed to assemble a mature virus. When protease is blocked, the new viral particles cannot mature. Protease Inhibitors in Development Several firms are trying to develop a new...

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Interactions of Protease Inhibitors and Blood Pressure Medications

I was recently placed on Tekturna and HCT to treat my blood pressure, and pravastatin for the P.I. increased cholesterol.Initially, the Tekturna dose of 150mg (the lowest prescription) seemed to create a neuropathy sensation on my left leg and arm....

Response from Keith Henry, M.D.

University of Minnesota, School of Medicine

I have seen no formal drug interaction studies with protease inhibitors and Aliskiren but the potential for interaction seems real.Aliskiren can cause muscle irritation in a small subset of patients. It is cleared from the body by the liver and that... Read more »

Protease Inhibitors Work for Some Not For Others

Why do some protease inhibitors seem to suppress viral loads to nearly 0in some patients and can not in other patients?...

Response from Cal Cohen, M.D., M.S.

Harvard Medical School

The most common reasons for protease inhibitor failure in my experienceare: Noncompliance: the drugs are taken erratically, with missed ordelayed doses Lack of effective combination therapy: the protease inhibitors aretaken in combination with... Read more »

PROTEASE INHIBITOR TREATMENT

I AM HIV POSITIVE, WITH A CD4 COUNT OF 394 AT LAST READING. MY DOCTOR HAD HAD ME ON 400 MG OF RITANOVIR AND 800 MG OF SAQUINAVIR. HE LATER DECREASED MY DOSAGE TO 200 MG OF RITANOVIR AND 400 MG OF SAQUINAVIR. SINCE THIS DECREASE IN DOSAGE, MY VIRAL...

Response from Cal Cohen, M.D., M.S.

Harvard Medical School

The usual doses when combining ritonavir and saquinavir are 400 to 600 mg ofritonavir twice daily plus 400 mg of saquinavir. When you use only 200 mg ofritonavir it may be enough to help increase saquinavir levels, but it'scertainly not enough... Read more »

Protease Inhibitors - Do They Work?

My lover has been HIV possitive for the last six years. On his last Doctor's appointment his T-Cell Count was way down. He is the healthiest he has ever been, feels great, but has been under some stress as of the last few months. Could this...

Response from Cal Cohen, M.D., M.S.

Harvard Medical School

The reason for the optimism surrounding protease inhibitors is that they work very well, and the more we learn about them, the more enthusiastic we become. Data from the Vancouver conference clearly show that the protease inhibitors notonly produce... Read more »

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lipodystrophy from protease inhibitors

Posted by Anonymous, 4 Replies

I have known about my HIV+ status now for 6 years, and God has blessed me with continued good health. I have accessed all the major medications, plus vitamins to help fight the disease. Once I started taking the new protease inhibitors, I started... Read more »

bone density loss due to protease inhibitors

Posted by Anonymous, 1 Reply

Curious as to latest info. on research into bone density loss due to HAART therapy. Most research data i've seen goes back to 99 or 2000. Any new data/research into this? Also any info. on clinical trials currently under way looking into this... Read more »

Hyperglycemia as a result of Protease Inhibitors

Posted by Anonymous

I found a product for reducing glucose levels. It is called Meishan Tea. They make 4 different kinds of tea and I have people that are showing tremendous results on all 4 kinds. However, the people that are presently taking the tea do not have AIDS.... Read more »

Protease Inhibitors - Hemophilia bleeds

Posted by akcol

Hi, my fiance is a Long Term NonProgressor - 24 years positive, co-infection HCV, with severe Hemophilia A.

This is a question for the gentlemen with Hemophilia please.
We're requesting any input about any Hemophilic PI increased unusual bleed... Read more »

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