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Protease Inhibitor Dosages

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Get the Facts
AIDS InfoNet

Protease Inhibitors in Development

... Protease Inhibitors Protease Inhibitors in Development PIs No Longer in Development NOTE: Several fact sheets describe drugs that are being tested against HIV: Fact Sheet 410 : nucleoside analog reverse transcriptase inhibitors (nukes)
Ask the Experts

PROTEASE INHIBITOR TREATMENT

I AM HIV POSITIVE, WITH A CD4 COUNT OF 394 AT LAST READING. MY DOCTOR HAD HAD ME ON 400 MG OF RITANOVIR AND 800 MG OF SAQUINAVIR. HE LATER DECREASED MY DOSAGE TO 200 MG OF RITANOVIR AND 400 MG OF SAQUINAVIR. SINCE THIS DECREASE IN DOSAGE, MY VIRAL...
Cal Cohen, M.D., M.S.

Response from Cal Cohen, M.D., M.S.

Harvard Medical School
The usual doses when combining ritonavir and saquinavir are 400 to 600 mg ofritonavir twice daily plus 400 mg of saquinavir. When you use only 200 mg ofritonavir it may be enough to help increase saquinavir levels, but it'scertainly not enough to... Read more »

Protease Inhibitors vs. Triple Nucleosides

In late June my doctor gave me the option to change my HIV medication to Trizivir, from Viracept and Combivir. The dosage (two pills a day as opposed to twelve pills a day), was very tempting. I questioned him about the lack of a protease inhibitor...
Cal Cohen, M.D., M.S.

Response from Cal Cohen, M.D., M.S.

Harvard Medical School
...A few comments to see what I can do to clarify what you've read.First - the guidelines. They do comment on some of the protease inhibitors that they recommend as part of a first combination, such as Viracept. They also comment on other... Read more »

hight cholesterol an triglicerides statins and reaction

I have high cholesterol and trigliderides my doctor gave me lipitor and zetia, I take sustiva ziagen and lexiva. Is there some interaction with my treatment or they are safe. thanks
Gerald Pierone, M.D.

Response from Gerald Pierone, M.D.

AIDS Research and Treatment Center of the Treasure Coast
...There is an interaction between Lipitor and protease inhibitors like Lexiva in which the blood levels of Lipitor tend to be higher. This is especially the case where Norvir is used as part Read more »

NNRTI & Lipitor

What is your feeling about Lipitor to lower cholesterol in patients on nnrti regimens? I've been on Sustiva/Truvada for 14 weeks with great results but have been battling high cholesterol for about 10 years, HDL high, LDL low, well controlled by...
Gerald Pierone, M.D.

Response from Gerald Pierone, M.D.

AIDS Research and Treatment Center of the Treasure Coast
...situation. The interactions are an issue with protease-inhibitors, especially ritonavir (Norvir). Lipitor can still be used with protease inhibitors, but with more caution and in lower dosage. Read more »
Articles
AIDS Survival Project

Drug Interactions of Protease Inhibitors and Psychiatric Medications

... Taken from an article by Dan H. Karasic and James W. Dilley Antiretroviral drugs -- especially protease inhibitors -- may interact with medications used to treat mood and anxiety disorders. Protease inhibitors have varying degrees of inhibition Read more »
GlaxoSmithKline

GSK Discontinues Clinical Development of Investigational Protease Inhibitor Brecanavir (640385)

...confirms that, due to insurmountable issues regarding formulation, the clinical development program for the investigational HIV protease inhibitor brecanavir has been discontinued. Brecanavir had reached Phase II development. This decision has... Read more »
U.S. Food and Drug Administration

Drugs that May Interact with Protease Inhibitors via CYP3A4 Metabolism -- Table V

...increased monitoring of therapeutic and adverse effectswhen concomitantly administering any of the following medicationswith protease inhibitors, especially for agents with narrowtherapeutic margins. Dosage reductions may be required for... Read more »
U.S. Food and Drug Administration

Protease Inhibitors Backgrounder Table of Contents

...regimensfor these drugs may result in development of a resistantstrain(s) of HIV that will not be susceptible to treatment withprotease inhibitors. Patients must be aware of the need to takethe complete dose to lessen the risk of potential... Read more »
Connect With Others

lipodystrophy from protease inhibitors

Posted by Anonymous, 4 Replies
...good health. I have accessed all the major medications, plus vitamins to help fight the disease. Once I started taking the new protease inhibitors, I started growing breasts and huge amount of fat in the stomache area...infact, my entire torso... Read more »

bone density loss due to protease inhibitors

Posted by Anonymous, 1 Reply
Curious as to latest info. on research into bone density loss due to HAART therapy. Most research data i've seen goes back to 99 or 2000. Any new data/research into this? Also any info. on clinical trials currently under way looking into this... Read more »

scare

Posted by dcboy20, 11 Replies
is there ever a day that you stop thinking about begin hiv postive it all i can think about and it drive me crazy even when i am at work i think about it any idea to get it off my mind Read more »

Protease Inhibitors - Hemophilia bleeds

Posted by akcol
Hi, my fiance is a Long Term NonProgressor - 24 years positive, co-infection HCV, with severe Hemophilia A. This is a question for the gentlemen with Hemophilia please. We're requesting any input about any Hemophilic PI increased unusual bleed... Read more »