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Protease Inhibitor Cocktail For Hiv

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AIDS InfoNet

Protease Inhibitors in Development

These drugs have not been approved by the Food and Drug Administration (FDA) for use against HIV. Protease Inhibitors These drugs block the protease enzyme. When new viral particles break off from an infected cell, protease cuts long protein strands into the parts needed to assemble a mature virus. When protease is blocked, the new viral particles cannot mature. Protease Inhibitors in Development Several firms are trying to develop a new...
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Protease Cocktail: A Road to Lipodystrophy?

In a recent response to a recent question I posed regarding my overt failure to gain weight after 12 weeks' of Sersotim, you said that I would have benefited more from Serostim had I removed the agents of Kaletra, Crixivan, and Viread from my...
Brian Conway, M.D.

Response from Brian Conway, M.D.

University of British Columbia
Crixivan is clearly associated with lipoatrophy, but more often with fat accumulation. The same can be said of Kaletra, although to a somewhat lesser extent. Viread is not associated with any of these complications. Of the protease inhibitors,... Read more »

protease inhibitors

Dear Mr. Sowadsky; Please describe Protease Inhibitors, how they work, and their role in drug cocktail therapy....
Rick Sowadsky, M.P.H.

Response from Rick Sowadsky, M.P.H.

Nevada State Health Division AIDS Program
Hi.Thank you for your question.Your question addresses so many issues that it's too long to answer in thisforum. However, a good written source for your questions is in a bookletentitled, "Protease Inhibitors: A New Family of Drugs for... Read more »

switching from norvir & azt & protease inhibitors

DEAR DR. LEE, i have all the adverse side effects of norvir and found dictionary.com as a site to give me their definitions. now, i know that adverse side effects can and are caused by everything & companies put contradictory side effects down:...
Sharon Lee, M.D.

Response from Sharon Lee, M.D.

University of Kansas Medical Center
The side effects which occur with the protease inhibitors (or other medications) are sometimes very uncomfortable or even harmful. Certainly each individual must weigh the pluses (controlling HIV and perhaps living longer) with the minuses... Read more »

Hypogonadism from protease inhibitors

I am a 33-yr-old male who was diagnosed two years ago during my seroconversion illness, and immediately began triple cocktail therapy with Crix/AZT/3TC, and have remained undetectable since that first diagnostic viral load test. After 13 months of...
J. B. Molaghan, N.P., A.C.R.N.

Response from J. B. Molaghan, N.P., A.C.R.N.

San Francisco General Hospital
HelloThanks for such a nicely detailed clinical summary. Although we assume that hypogonadism is only associated with HIV disease progression, we don't really know if it occurred in early HIV disease, because we never looked for it. In fact,... Read more »
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lipodystrophy from protease inhibitors

Posted by Anonymous, 4 Replies
I have known about my HIV+ status now for 6 years, and God has blessed me with continued good health. I have accessed all the major medications, plus vitamins to help fight the disease. Once I started taking the new protease inhibitors, I started... Read more »

Protease Inhibitors - Hemophilia bleeds

Posted by akcol
Hi, my fiance is a Long Term NonProgressor - 24 years positive, co-infection HCV, with severe Hemophilia A.

This is a question for the gentlemen with Hemophilia please.
We're requesting any input about any Hemophilic PI increased unusual bleed... Read more »

Looking for people using drug cocktails

Posted by Anonymous
I am a graduate student at Quinnipiac University in Hamden, CT. I am working on a story about reactions to drug cocktails and protease inhibitors. If you have had a positive reaction, for example, your T-cell count has gone up after taking them,... Read more »

Is the triple cocktail helping to spread AIDS?

Posted by Anonymous, 6 Replies
I've written what is currently the only computer application solely dedicated to the mathematical analysis of HIV. It's called HIV pathogenesis modeler, and can be downloaded at:
http://www.agmh.org/softw.htm

While using the SI model in the program, I... Read more »