Protease Inhibitor Antiretroviral Medicine

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Protease Inhibitors in Development

These drugs have not been approved by the Food and Drug Administration (FDA) for use against HIV. Protease Inhibitors These drugs block the protease enzyme. When new viral particles break off from an infected cell, protease cuts long protein strands into the parts needed to assemble a mature virus. When protease is blocked, the new viral particles cannot mature. Protease Inhibitors in Development Several firms are trying to develop a new...

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Injectable Protease Inhibitors

Given the gastronitestinal side effects that make protease inhibitors so unpleasant shouldn't there by an injectable option/formulation to bypass the stomach? Fuzeon has problems too, but many people do well for years injecting that or insulin....

Response from Keith Henry, M.D.

University of Minnesota, School of Medicine

Your point is well taken though there are costs and side effects associated with the subcutaneous injection route as well. We have had some patients in whom we have put in a percutanous feeding tube from the skin to the stomach or small bowel to... Read more »

azt and protease inhibitors in first trimester

Protease inhibitors and azt can be taken together, but can they be taken together during the first trimester of pregnancy without harm to the fetus?...

Response from Brooks Jackson, M.D.

Johns Hopkins University, School of Medicine

There is limited safety data on the use of protease inhibitors used in conjunction with AZT or other antiretrovirals during the first trimester of pregnancy. The Public Health Service guidelines still recommend the initiation of AZT and/or the... Read more »

Protease Inhibitors Work for Some Not For Others

Why do some protease inhibitors seem to suppress viral loads to nearly 0in some patients and can not in other patients?...

Response from Cal Cohen, M.D., M.S.

Harvard Medical School

The most common reasons for protease inhibitor failure in my experienceare: Noncompliance: the drugs are taken erratically, with missed ordelayed doses Lack of effective combination therapy: the protease inhibitors aretaken in combination with... Read more »

Protease Inhibitors... Cause Bone Loss???

Hi... I'm currently taking Reyataz and I just read something about Protease Inhibitors and bone loss... Do they cause bone loss? I already have osteoperosis and have suffered awful compression fractures down my spine and DO NOT need any more...

Response from Sharon Lee, M.D.

University of Kansas Medical Center

First, always check with your doctor when you read things about your meds. It is important to get accurate info. SOme of the PI's may increase the rate of bone loss, although there are differences among the protease inhibitors (different side... Read more »

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lipodystrophy from protease inhibitors

Posted by Anonymous, 4 Replies

I have known about my HIV+ status now for 6 years, and God has blessed me with continued good health. I have accessed all the major medications, plus vitamins to help fight the disease. Once I started taking the new protease inhibitors, I started... Read more »

bone density loss due to protease inhibitors

Posted by Anonymous, 1 Reply

Curious as to latest info. on research into bone density loss due to HAART therapy. Most research data i've seen goes back to 99 or 2000. Any new data/research into this? Also any info. on clinical trials currently under way looking into this... Read more »

Hyperglycemia as a result of Protease Inhibitors

Posted by Anonymous

I found a product for reducing glucose levels. It is called Meishan Tea. They make 4 different kinds of tea and I have people that are showing tremendous results on all 4 kinds. However, the people that are presently taking the tea do not have AIDS.... Read more »

Protease Inhibitors - Hemophilia bleeds

Posted by akcol

Hi, my fiance is a Long Term NonProgressor - 24 years positive, co-infection HCV, with severe Hemophilia A.

This is a question for the gentlemen with Hemophilia please.
We're requesting any input about any Hemophilic PI increased unusual bleed... Read more »

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