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Progressive Cd4 T-cells Killing

Here's a taste of what has to offer on this topic:
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AIDS InfoNet

CD4 Cell Tests

...not exact. What Factors Influence a CD4 Cell Count? The CD4 cell value can change a lot. Time of day, fatigue, and stress can affect the test results. It's best to have blood drawn at the same time of day for each CD4 cell test, and to use the same laboratory. Infections can have a large impact on CD4 cell counts. When your body fights an infection, the number of white blood cells (lymphocytes) goes up. CD4 counts go up, too. ...
Ask the Experts

Need your help to help (Thanks)

Afternoon Dr First and like always, thanks for all your help and support. Since I have been diagnosed HIV+ (more than 2 years ago) I started helping HIV people in my community as much as I can (listening them, supporting them, guide them to the...
Robert J. Frascino, M.D.

Response from Robert J. Frascino, M.D.

The Robert James Frascino AIDS Foundation
...T-4 cells, also called CD4+, are "helper" cells. They lead the attack against infections. T-8 cells (CD8+) are "suppressor" cells that end the immune response. CD8 cells can also be "killer" cells that kill cancer cells and cells infected with a... Read more »

Gene Therapy? (GENE THERAPY, 2009)

Hi Dr. Bob,Could you discuss recent discoveries in stem cell transplants and gene therapy? It seems very promising. I have read some things about it, but it is never covered in any of the information in The Body.
Robert J. Frascino, M.D.

Response from Robert J. Frascino, M.D.

The Robert James Frascino AIDS Foundation
...Hi,Gene therapy and stem cell transplants never get covered in any of the information on The Body? Really??? Hmm . . . see below for a small sample of what's Read more »


Hi Dr Bob, l love your work, l am recently infected with HIV, but not on meds cd4 375 and virol load 84,000, l will be on meds soon but looking for a new treatment, Can you explain to me the difference between HIV drug and gene therapies??? Which is...
Robert J. Frascino, M.D.

Response from Robert J. Frascino, M.D.

The Robert James Frascino AIDS Foundation
...weapons that destroy cells infected with HIV, the virus that causes AIDS. Their novel strategy of genetically engineering immune cells to redirect their infection-fighting ability toward killing HIV-infected cells could lead to an entirely new... Read more »

If HIV kills CD4 cells that present themselves, can high CD4 levels in first years of infection later result in faster progression to AIDS?

Dr. Holodniy, I am searching for the right words, but have an important question:It is often assumed that the more CD4 cells in a T cell subset, the better. But,in that the more CD4's that present themselves, the more for HIV to kill, could this be...
Mark Holodniy, M.D., F.A.C.P., C.I.C.

Response from Mark Holodniy, M.D., F.A.C.P., C.I.C.

Stanford University, School of Medicine
...Not alot of studies on this issue. It is usually assumed that those infected people with such high CD4 counts, usually have low or undetectable viral loads, indicating an immune system with better capability to contain viral replication. Read more »
Treatment Action Group

Dendritic Cells in Drag: Inauspicious Debut for HIV Specific CTLs; New Concerns about IL-12; Neutralizing Approaches for "Bad" Cytokines; Parke-Davis Targets Cellular Factors

...(DC) in the design of novel approaches to prophylactic and therapeutic HIV vaccines. DC represent a very small subset of immune cells that are potent antigen-presenting cells (APC) known to be top-of-the-line inducers of T-cell responses to HIV.... Read more »
Gay Men's Health Crisis

Stalking HIV Immune Dysregulation

...researchers have raised the possibility that the thymus compensates for T-cell loss by increasing its production of replacement cells, although this theory remains controversial. Part of the difficulty lays in interpreting TREC levels. Since... Read more »
AIDS Community Research Initiative of America

Second Time Around: T-cell Memory and HIV

...other immune system players like the CD8 killer T-cells. CD8 killer T-cells perform the vital task of identifying and destroying cells that have been invaded by infectious agents. Getting Specific A typical adult has a lot of T-cells running... Read more »
International AIDS Society

Africa Stands at a Threshold in HIV Response

...people of Zulu/Xhosa ethnicity who are chronically infected with subtype C virus. Dr. Walker explored several facets of how T lymphocytes fall short in fighting off HIV, including how genetics of the infected person affect HIV control, how... Read more »
Connect With Others

What is a T-Cell or CD4 Count?

Posted by TheBody
...What Is a T-Cell or CD4 Count? Your T-cell count, also known as a CD4 count, reveals the number of T cells in your body. A T cell is a special kind of white blood cell, and the more you have, the stronger your immune system is. When Read more »

Recently Diagnosed needs help and advice

Posted by pozargie, 5 Replies
...for medical medical support I dont care. I want to live!!! Things work very slow in this part of the world... to ge to my CD4 and virus load count I have to wait 2 weeks more!!! This waiting thing is killing me!!! Should I ask my doctor for... Read more »

Good information on the board

Posted by Jackie_Blue, 2 Replies
...cells/uL 3 AIDS less than 200 cells/uL Your disease classification -- asymptomatic, ARC, or AIDS -- is based on the lowest t-cell test you ever had. For example, if you once tested at 180 ... but then got a big boost from a new protease... Read more »

After ARS?

Posted by Anonymous, 2 Replies
So what happens after ARS? Aren't there other symptoms ongoing? I have read about lymph nodes being swollen, but what about other problems? Is there nothing? Or is there typically some sort of ongoing issue? Read more »