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Progressive Cd4 T-cells Killing

Here's a taste of what TheBody.com has to offer on this topic:
Get the Facts
The Well Project

Understanding CD4 Cells and CD4 Cell Tests

The Basics CD4 Count and HIV CD4 Count and HIV Treatment CD4 Cell Test The Bottom Line The Basics Your immune system protects your body by fighting germs and infections.White blood cells are an important part of your immune system. HIV infects and destroys a type of white blood cell called aCD4 cell (sometimes called a T-cell). As the immune system loses CD4 cells, it becomes weaker and is less able tofight off germs. When it...
Ask the Experts

If HIV kills CD4 cells that present themselves, can high CD4 levels in first years of infection later result in faster progression to AIDS?

Dr. Holodniy, I am searching for the right words, but have an important question:It is often assumed that the more CD4 cells in a T cell subset, the better. But,in that the more CD4's that present themselves, the more for HIV to kill, could...
Mark Holodniy, M.D., F.A.C.P., C.I.C.

Response from Mark Holodniy, M.D., F.A.C.P., C.I.C.

Stanford University, School of Medicine
Not alot of studies on this issue. It is usually assumed that those infected people with such high CD4 counts, usually have low or undetectable viral loads, indicating an immune system with better capability to contain viral replication. It has... Read more »

CD4 Count V. CD4% Count (ABSOLUTE CD4 COUNT VERSUS CD4%, 2010) (WHEN TO START TREATMENT, 2010)

Hi,I was diagnosed with HIV around 15 months ago. Since then my health has been good (especially in the last six months) but my CD4 count has fallen a bit rapidly from 470 to 371 to 324 over this time period. However, my CD4 percentage count has...
Robert J. Frascino, M.D.

Response from Robert J. Frascino, M.D.

The Robert James Frascino AIDS Foundation
Hello,You are correct: The CD4% is generally considered the more accurate indicator of immune integrity, as it doesn't tend to fluctuate as much due to intercurrent illnesses and other non-HIV-related factors. (See below.)Regarding beginning... Read more »

CD4 and CD4/CD8 ratio

Dear Mark, I have been recently diagnosed HIV+ (June 02) and have some questions regarding both the CD4/CD8 ratio and CD4 which do not seem to be spoken about as much as the CD4 absolute.My first question is what exactly are CD8 cells? What happens...
Mark Holodniy, M.D., F.A.C.P., C.I.C.

Response from Mark Holodniy, M.D., F.A.C.P., C.I.C.

Stanford University, School of Medicine
Lots of great questions. CD8 cells are the major defense in your immune system against HIV. For the most part they are cytotoxic t cells, meaning they kill HIV infected CD4 cells. They don't usually get infected with HIV. They do increase... Read more »

Part 2 to question on stagant CD 4 or slow increase in CD 4 cells over a few years.

Today question: Sir, I have been taking Truvuda and Efavirenz on a regular basis prescript by my doctor since my diagnose in 2009. The first time when I was down with a sereve flu, the hospital tested my CD 4 and it was only 132 in total. They...
Mark Holodniy, M.D., F.A.C.P., C.I.C.

Response from Mark Holodniy, M.D., F.A.C.P., C.I.C.

Stanford University, School of Medicine
Again on average, the risk of progression is greater with lower CD4 counts. However, everyone comes to HIV infection differently, and so, it is very difficult to offer individual predictions because of different viruses, underlying immune systems... Read more »
Connect With Others

CD4+Tcell count indicative of nothing.

Posted by TonyF, 4 Replies
This, rather than being a myth the public promotes, could be considered a myth that the medical establishment promotes. We are led to believe that our bi-yearly doctor checkup of our CD4+Tcell count is a good baseline determination of where we... Read more »

High VL/High CD4: what to do?

Posted by Anonymous, 7 Replies
Hi from Italy.
I'm HIV+ since Feb 00 and I discovered my status in June.
Since then I have regularly checked my situation having always high VL (from 60K to 240K) and high CD4 (from 750 to 1000).
My last analysis are VL: 200K and CD4: 907.
My doctor is... Read more »

What is a T-Cell or CD4 Count?

Posted by TheBody
What Is a T-Cell or CD4 Count?

Your T-cell count, also known as a CD4 count, reveals the number of T cells in your body. A T cell is a special kind of white blood cell, and the more you have, the stronger your immune system is. When you were infected... Read more »

IL-2 Induces Sustained CD4 Cell Increases

Posted by Anonymous, 1 Reply
IL-2 Induces Sustained CD4 Cell Increases in HIV-Infected Patients


By Deborah Mitchell

TORONTO, Sep 20 (Reuters Health) - The addition of recombinant interleukin-2 (IL-2) to an HIV antiretroviral therapy produces an increase in CD4+ T-cell counts,... Read more »