Pep Treatment Guidelines

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Get the Facts

Treatment After Exposure to HIV

For serious exposures, the U.S. Public Health Service recommends using a combination of three approved ARVs for four weeks. For less serious exposure, the guidelines recommend four weeks of treatment with two drugs: zidovudine (Retrovir, AZT) and lamivudine (Epivir, 3TC). In January 2001, the Centers for Disease Control warned against using nevirapine (Viramune) for PEP because of the risk of liver damage. See Fact Sheet 431 for more...

Ask the Experts

Has PEP regimen guideline been revised since 2009?

Hello Dr. Bob,I wrote to you before about PEP due to potential HIV exposure, and you responded with accurate information that not even my primary physician has. I've come to you again for similar consultation, please help me as I'm a...

Response from Robert J. Frascino, M.D.

The Robert James Frascino AIDS Foundation

Hello P,There has been no change in nPEP (non-occupational post-exposure prophylaxis) guidelines. You are correct: a recommended course of nPEP is a full 28 days. Call the HIV specialist and advise the ER doctor did not prescribe the correct PEP... Read more »

PEP Guideline Question

Dear Dr. Bob,I finally realized that I am addicted to your site since I have to check your new postings every day.I remember reading one of your threads that PEP does not (or rarely) cause delayed seroconversion. Therefore, is it true that the...

Response from Robert J. Frascino, M.D.

The Robert James Frascino AIDS Foundation

Hi Still Worried Canuck,Yep. The post-PEP testing guidelines are the same as testing guidelines for a significant HIV exposure. Dr. Bob... Read more »

PEP guideline revised test

Hello doctors.I'm from Brazil, and I have a question.In late 2011, the United Kingdom updated guideline for use of PEP (PEPSE). Among the changes, adopt as a final test 12 weeks after the end of PEP. I wonder if you agree that test 12 weeks...

Response from David Wohl, M.D.

University of North Carolina - Chapel Hill

I do agree.DW... Read more »

Updated HIV Post Exposure Prophylaxis (PEP) Guidelines

I recently got stuck with a needle which was in an HIV positive patient's gum. The needle did not have any associated blood. Would you recommend prophylactic AZT in such a case?...

Response from Rick Sowadsky, M.P.H.

Nevada State Health Division AIDS Program

Hi. Thank you for your question. When deciding on whether HIV Post Exposure Prophylaxis (PEP) is indicated in a specific case, you need to ask yourself the following questions:1) Was the patient KNOWN to be HIV positive or KNOWN to be at high... Read more »

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Connect With Others

Community Member Sought for HIV Treatment Guidelin

Posted by Anonymous

Community Member Sought for HIV Treatment Guidelines Panel

The Panel on Clinical Practices for Treatment of HIV Infection is seeking nominations for a community representative to serve a 3-year term on their Adult Guidelines Panel. The ideal... Read more »

PEP and testing for G-Man

Posted by Anonymous, 1 Reply

G-Man -

I have lifted a quote of yours from another post:

"If you are actually infected the disease will start replicating immediately and that is where ARS comes from in the 2 to 6 week range. The only things that can delay replication is PEP or... Read more »

Pep warranted/Great risk after brused Condom?

Posted by Capricornicus, 2 Replies

Dear all,

Today I had a sexual encounter where I was penetrated analy by a guy which claimed to be HIV-. We used three condoms to make sure there were not worn out. After penetrating me for 5 minutes with the last condom we noticed there was a whole... Read more »

PEP

Posted by je5872, 2 Replies

has anyone ever taken PEP. I began taking PEP 4 hrs post exposure. I was top with hiv+ guy on no meds when condom broke. i immediately washed and urinated. Has anyone had this experince? do they feel the PEP was effective? Read more »

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