Nucleosides In Use For Hiv

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Nucleoside Analog Reverse Transcriptase Inhibitors in Development

These drugs have not been approved by the Food and Drug Administration (FDA) for use against HIV. Nucleoside Analog Reverse Transcriptase Inhibitors These drugs stop HIV from multiplying by blocking the reverse transcriptase enzyme. This enzyme changes HIV's genetic material (RNA) into the form of DNA. This step has to occur before HIV's genetic code gets combined with an infected cell's own genetic codes. The nucleoside analogs (often...

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Protease Inhibitors vs. Triple Nucleosides

In late June my doctor gave me the option to change my HIV medication to Trizivir, from Viracept and Combivir. The dosage (two pills a day as opposed to twelve pills a day), was very tempting. I questioned him about the lack of a protease inhibitor...

Response from Cal Cohen, M.D., M.S.

Harvard Medical School

A few comments to see what I can do to clarify what you've read.First - the guidelines. They do comment on some of the protease inhibitors that they recommend as part of a first combination, such as Viracept. They also comment on other... Read more »

nucleoside -vs- nucleotide

Doc, What is a determinant for using nucleotide inleiu of using nucleoside in a treatment regimen? I'm sorry but I really don't understand.Thank you...

Response from Andrew T. Pavia, M.D.

University of Utah, School of Medicine

Both nucleotides and nucleosides work on reverse transcriptase by blocking the extension of new DNA chains. There is only one nucleotide in development, PMPA (tenofovir), and it will be largely used when there is resistance to standard... Read more »

nucleoside options

You answered a question of mine on 10/18 regarding use of Reyataz. Currently I am on Ziagen, Viread, Reyataz w/Norvir. I developed resistance to Sustiva in 2003 so I believe that family of drugs is no longer an option for me (that is the only drug I...

Response from Brian Conway, M.D.

University of British Columbia

The issue is that a single mutation (at codon 65) confers resistance to both tenofovir and abacavir, so that the combination is more prone to fail than others. A combination of zidovudine and tenofovir may well avoid this problem, although it... Read more »

change of treatment . only nucleoside analogues?

Dear doctors: I've been just changed (after 4 months without medication)to videx/epivir/ziagen, due to high lactic acidosis and resistances results on my last resistance test. I have 280.000 copies viral load and 250 cd4. According to my...

Response from Andrew T. Pavia, M.D.

University of Utah, School of Medicine

I am a bit concerned about the story here. It is always hard to give you a fair answer without knowing the past history in detail and seeing your resistance tests, and even if I had that info, the purpose of the site is to give you information for... Read more »

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AbacavirLamivudine to treat HIV infection.

Posted by jenniferdraper

AbacavirLamivudine is used to treat HIV infection. This combination medication is used with other medications. It belongs to a class of drugs known as nucleoside reverse transcriptase inhibitors. Read more »

Early HIV Treatment Failure Linked to Didanosine/T

Posted by TwinsDad, 1 Reply

NEW YORK (Reuters Health) Aug 23 - The combination of the antiretroviral agents didanosine, tenofovir, and efavirenz is associated with a high virological failure rate in treatment-naive patients with HIV, British investigators report.

Dr. Desmond... Read more »

Vasculitis and HIV

Posted by Anonymous, 3 Replies

Does anyone know about vasculitis and HIV? Read more »

HIV/AIDS Lipoatrophy (Facial Wasting)

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HIV/AIDS Lipoatrophy (Facial Wasting)

Individuals living with HIV and AIDS may not only have to deal with the threat of illness but the toll of illness. All that is required to stay healthy and alive can leave an everlasting mark! I'm referring to... Read more »

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