Nucleoside Analogs For Hiv Effect

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Nucleoside Analog Reverse Transcriptase Inhibitors in Development

These drugs have not been approved by the Food and Drug Administration (FDA) for use against HIV. Nucleoside Analog Reverse Transcriptase Inhibitors These drugs stop HIV from multiplying by blocking the reverse transcriptase enzyme. This enzyme changes HIV's genetic material (RNA) into the form of DNA. This step has to occur before HIV's genetic code gets combined with an infected cell's own genetic codes. The nucleoside analogs (often...

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Protease Inhibitors vs. Triple Nucleosides

In late June my doctor gave me the option to change my HIV medication to Trizivir, from Viracept and Combivir. The dosage (two pills a day as opposed to twelve pills a day), was very tempting. I questioned him about the lack of a protease inhibitor...

Response from Cal Cohen, M.D., M.S.

Harvard Medical School

A few comments to see what I can do to clarify what you've read.First - the guidelines. They do comment on some of the protease inhibitors that they recommend as part of a first combination, such as Viracept. They also comment on other... Read more »

Why no adenosine analog NRTI?

Sorry if this is a bit off-topic but I was wondering why there is no adenosine analog NRTI available? Was there something about adenosine that made it an undesirable nucleoside to derive an analog of?...

Response from Mark Holodniy, M.D., F.A.C.P., C.I.C.

Stanford University, School of Medicine

ddI would be considered in this group as the dideoxyinosine is converted to adenosine inside the cell.... Read more »

nucleoside options

You answered a question of mine on 10/18 regarding use of Reyataz. Currently I am on Ziagen, Viread, Reyataz w/Norvir. I developed resistance to Sustiva in 2003 so I believe that family of drugs is no longer an option for me (that is the only drug I...

Response from Brian Conway, M.D.

University of British Columbia

The issue is that a single mutation (at codon 65) confers resistance to both tenofovir and abacavir, so that the combination is more prone to fail than others. A combination of zidovudine and tenofovir may well avoid this problem, although it... Read more »

Inosine effect HIV Test

White Male had 1 time unprotected vaginal sex with a CSW in US. ON day 25 white male beganworking out taking supplements to include "Inosine" and other immune enhancement supplements (Echinechia, Goldenseal, Melatonin, etc.). White male...

Response from Benjamin Young, M.D., Ph.D.

Rocky Mountain CARES

Hi and thanks for your test.Inosine has no effect on HIV or the body's ability to mount an antibody response to HIV.1) No.2) No.3) Depends. If the person is HIV infected, then a HIV DNA PCR should be positive4) Yes. Be well,BY... Read more »

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Jellybean Analogy

Posted by Anonymous, 1 Reply

I found once a sheet comparing taking anti-HIV meds to taking different colored jellybeans - for people without HIV to understand how hard it was. It said stuff like "take the blue jellybean half an hour before eating but not with the red jellybean,... Read more »